Serveur d'exploration Chloroquine - Exploration (Accueil)

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Les termes de plus forte occurence

1423were
1390treatment
1287cells
1217abstract
1187patients
1185these
1174cell
1120disease
937study
911may
891clinical
865also
849associated
844results
816but
794lung
787chloroquine
767therapy
753cancer
739induced
734drug
721after
694other
692however
686activity
680effects
646both
621drugs
605systemic
602effect
596patient
593role
587increased
584most
581than
579anti
563review
563human
552potential
552high
550autophagy
542protein
541well
539found
533studies
520had
514all
513therapeutic
508present
502case
495non
486treated
481showed
479lupus
478report
474including
473expression
467diseases
451inhibition
449only
449new
441response
440vitro
436tumor
435agents
430levels
430arthritis
428reported
427there
421during
416erythematosus
413significant
412specific
412cases
410mechanisms
410development
409pulmonary
408when
403observed
398mediated
396due
395who
395significantly
395related
393diagnosis
392inflammatory
388years
387important
386data
383could
382through
382mechanism
380further
378against
375first
371rheumatoid
363year
360different
357syndrome
356dependent
355developed
349while
346resistance
343addition
340pathway
340findings
340although
339novel
338growth
338factor
336inhibitor
333function
332vivo
332three
332analysis
329chronic
328various
327several
327dose
326low
325cellular
324effective
323severe
321tissue
321compared
320increase
319here
318time
318suggest
313death
311demonstrated
309small
309methods
306system
303presence
302evidence
301receptor
300activation
297inhibited
295control
294title
294known
294background
293old
291infection
291gene
289many
289current
288blood
286target
283major
283apoptosis
281common
281combination
280acid
277involvement
276shown
275literature
273via
273inhibitors
273decreased
272italic
271within
271changes
270type
270investigated
268thus
264involved
263revealed
262immune
259without
258like
257should
257process
257molecular
255survival
255presented
255hydroxychloroquine
254normal
254malaria
252factors
252acute
251those
251studied
251reduced
249enhanced
249dna
247group
247did
245par
244months
244higher
243recent
243primary
243possible
242skin
242cause
240efficacy
239similar
239active
238rare
238formation
237signaling
237positive
237number
236identified
235intracellular
235features
235early
234targeting
234membrane
233level
232following
231resistant
231compounds
230symptoms
229lysosomal
226sle
226risk
225liver
225conclusion
224degradation
224caused
222respectively
222binding
219will
219therefore
219serum
219over
219multiple
219management
219four
217sarcoidosis
217proteins
217long
217either
215conditions
213rate
213furthermore
212complex
212characterized
212age
210manifestations
210because
209provide
209mice
209cutaneous
208model
207performed
205previously
203whether
203underlying
203association
201under
200plasmodium
200accumulation
199remains
198toxicity
198lines
197progression
197concentrations
197agent
196often
196considered
195summary
195children
194proliferation
193show
193evaluated
192described
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190antimalarial
189inflammation
188sec
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187less
187autoimmune
184any
183properties
181therapies
181synthesis
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181delivery
180research
179pathways
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179administration
178oral
177term
177interstitial
177being
176seen
176recently
176antibodies
176activities
175kinase
175confirmed
174production
174determined
174action
173range
172rat
172mortality
172lower
172cytotoxicity
171promising
171objective
170aim
169wiley
169tissues
169lesions
168moreover
168ability
167induction
167disorders
166unknown
166investigate
166cytotoxic
166biological
166available
164still
164pathogenesis
164life
164falciparum
164each
164detected
163mean
163exposure
163describe
163damage
162stress
162side
162induces
162course
161suggesting
160large
160followed
160biopsy
159strategies
159indicated
159indicate
159activated
158whereas
158understanding
158failure
158discussed
157period
157metabolism
156together
156taken
156examined
156approach
155targeted
155since
155methotrexate
155isolated
155despite
155autophagic
154species
154might
154inhibit
153types
153even
153diagnosed
152highly
152follow
151decrease
149prognosis
149corticosteroids
149carcinoma
148uptake
148responses
148medical
148immunosuppressive
148five
147result
147renal
147limited
147index
146very
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145systems
145improved
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144surface
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144functional
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143single
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143derived
142variety
142required
142mouse
141tested
141reviewed
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141history
141anticancer
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138total
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138key
137increasing
137before
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136reports
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136plasma
136knowledge
136groups
136elevated
136demonstrate
135release
135especially
135compound
134poor
134loss
134identify
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133reduction
133reactive
133need
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133day
133conclusions
132sensitive
132resulting
132potent
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131currently
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129second
129natural
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129improve
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128woman
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128treatments
128negative
127treat
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126good
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125oxygen
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124heart
124clinically
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123epithelial
122metabolic
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122general
121virus
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121genes
121female
121established
120six
120previous
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120evaluate
120duration
119viral
119include
118then
118play
118develop
118cancers
117received
117out
117necrosis
117host

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