Food interaction of oral uptake of iron / a clinical trial using 59Fe.
Identifieur interne : 000731 ( Ncbi/Curation ); précédent : 000730; suivant : 000732Food interaction of oral uptake of iron / a clinical trial using 59Fe.
Auteurs : Hans Lundqvist [Suède] ; Folke SjöbergSource :
- Arzneimittel-Forschung [ 0004-4172 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Anemia, Iron-Deficiency (drug therapy), Beverages, Citrus sinensis, Cross-Over Studies, Data Interpretation, Statistical, Erythrocytes (metabolism), Female, Ferric Compounds (pharmacokinetics), Food-Drug Interactions, Hemoglobins (metabolism), Humans, Iron (blood), Iron (pharmacokinetics), Iron Radioisotopes, Male, Tea, Transferrin (metabolism).
- MESH :
- chemical , blood : Iron.
- chemical , metabolism : Hemoglobins, Transferrin.
- chemical , pharmacokinetics : Ferric Compounds, Iron.
- drug therapy : Anemia, Iron-Deficiency.
- metabolism : Erythrocytes.
- Adult, Beverages, Citrus sinensis, Cross-Over Studies, Data Interpretation, Statistical, Female, Food-Drug Interactions, Humans, Iron Radioisotopes, Male, Tea.
Abstract
A primary objective of the study was to evaluate how food as well as a specific enhancer or an inhibitor of iron uptake affect erythrocyte iron uptake after oral administration of iron(III)-hydroxide polymaltose complex (IPC, Maltofer) in subjects with or without iron deficiency. Secondary objectives of the study were 1. to compare the uptake of 59Fe in erythrocytes between subjects with or without iron deficiency, 2. to evaluate the 59Fe activity in plasma after oral administration of IPC and 3. to evaluate the safety of oral administration of IPC by adverse events (AEs), vital signs, and hematological and clinical chemistry parameters.
DOI: 10.1055/s-0031-1296689
PubMed: 17691590
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pubmed:17691590Le document en format XML
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