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Food interaction of oral uptake of iron / a clinical trial using 59Fe.

Identifieur interne : 000B67 ( PubMed/Corpus ); précédent : 000B66; suivant : 000B68

Food interaction of oral uptake of iron / a clinical trial using 59Fe.

Auteurs : Hans Lundqvist ; Folke Sjöberg

Source :

Arzneimittel-Forschung [ 0004-4172 ] ; 2007.

RBID : pubmed:17691590

English descriptors

KwdEn :
- Adult, Anemia, Iron-Deficiency (drug therapy), Beverages, Citrus sinensis, Cross-Over Studies, Data Interpretation, Statistical, Erythrocytes (metabolism), Female, Ferric Compounds (pharmacokinetics), Food-Drug Interactions, Hemoglobins (metabolism), Humans, Iron (blood), Iron (pharmacokinetics), Iron Radioisotopes, Male, Tea, Transferrin (metabolism).
MESH :
- chemical , blood : Iron.
- chemical , metabolism : Hemoglobins, Transferrin.
- chemical , pharmacokinetics : Ferric Compounds, Iron.
- drug therapy : Anemia, Iron-Deficiency.
- metabolism : Erythrocytes.
- Adult, Beverages, Citrus sinensis, Cross-Over Studies, Data Interpretation, Statistical, Female, Food-Drug Interactions, Humans, Iron Radioisotopes, Male, Tea.

Abstract

A primary objective of the study was to evaluate how food as well as a specific enhancer or an inhibitor of iron uptake affect erythrocyte iron uptake after oral administration of iron(III)-hydroxide polymaltose complex (IPC, Maltofer) in subjects with or without iron deficiency. Secondary objectives of the study were 1. to compare the uptake of 59Fe in erythrocytes between subjects with or without iron deficiency, 2. to evaluate the 59Fe activity in plasma after oral administration of IPC and 3. to evaluate the safety of oral administration of IPC by adverse events (AEs), vital signs, and hematological and clinical chemistry parameters.

DOI: 10.1055/s-0031-1296689
PubMed: 17691590

Links to Exploration step

pubmed:17691590

Le document en format XML

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<author><name sortKey="Lundqvist, Hans" sort="Lundqvist, Hans" uniqKey="Lundqvist H" first="Hans" last="Lundqvist">Hans Lundqvist</name>
<affiliation><nlm:affiliation>Department of Biomedical Radiation Sciences, Uppsala University, Uppsala, Sweden. Hans.Lundqvist@bms.uu.se</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sjoberg, Folke" sort="Sjoberg, Folke" uniqKey="Sjoberg F" first="Folke" last="Sjöberg">Folke Sjöberg</name>
</author>
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<idno type="wicri:Area/PubMed/Corpus">000B67</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Food interaction of oral uptake of iron / a clinical trial using 59Fe.</title>
<author><name sortKey="Lundqvist, Hans" sort="Lundqvist, Hans" uniqKey="Lundqvist H" first="Hans" last="Lundqvist">Hans Lundqvist</name>
<affiliation><nlm:affiliation>Department of Biomedical Radiation Sciences, Uppsala University, Uppsala, Sweden. Hans.Lundqvist@bms.uu.se</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sjoberg, Folke" sort="Sjoberg, Folke" uniqKey="Sjoberg F" first="Folke" last="Sjöberg">Folke Sjöberg</name>
</author>
</analytic>
<series><title level="j">Arzneimittel-Forschung</title>
<idno type="ISSN">0004-4172</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Anemia, Iron-Deficiency (drug therapy)</term>
<term>Beverages</term>
<term>Citrus sinensis</term>
<term>Cross-Over Studies</term>
<term>Data Interpretation, Statistical</term>
<term>Erythrocytes (metabolism)</term>
<term>Female</term>
<term>Ferric Compounds (pharmacokinetics)</term>
<term>Food-Drug Interactions</term>
<term>Hemoglobins (metabolism)</term>
<term>Humans</term>
<term>Iron (blood)</term>
<term>Iron (pharmacokinetics)</term>
<term>Iron Radioisotopes</term>
<term>Male</term>
<term>Tea</term>
<term>Transferrin (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Iron</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemoglobins</term>
<term>Transferrin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Ferric Compounds</term>
<term>Iron</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anemia, Iron-Deficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Erythrocytes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Beverages</term>
<term>Citrus sinensis</term>
<term>Cross-Over Studies</term>
<term>Data Interpretation, Statistical</term>
<term>Female</term>
<term>Food-Drug Interactions</term>
<term>Humans</term>
<term>Iron Radioisotopes</term>
<term>Male</term>
<term>Tea</term>
</keywords>
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<front><div type="abstract" xml:lang="en">A primary objective of the study was to evaluate how food as well as a specific enhancer or an inhibitor of iron uptake affect erythrocyte iron uptake after oral administration of iron(III)-hydroxide polymaltose complex (IPC, Maltofer) in subjects with or without iron deficiency. Secondary objectives of the study were 1. to compare the uptake of 59Fe in erythrocytes between subjects with or without iron deficiency, 2. to evaluate the 59Fe activity in plasma after oral administration of IPC and 3. to evaluate the safety of oral administration of IPC by adverse events (AEs), vital signs, and hematological and clinical chemistry parameters.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17691590</PMID>
<DateCreated><Year>2007</Year>
<Month>8</Month>
<Day>13</Day>
</DateCreated>
<DateCompleted><Year>2007</Year>
<Month>09</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0004-4172</ISSN>
<JournalIssue CitedMedium="Print"><Volume>57</Volume>
<Issue>6A</Issue>
<PubDate><Year>2007</Year>
</PubDate>
</JournalIssue>
<Title>Arzneimittel-Forschung</Title>
<ISOAbbreviation>Arzneimittelforschung</ISOAbbreviation>
</Journal>
<ArticleTitle>Food interaction of oral uptake of iron / a clinical trial using 59Fe.</ArticleTitle>
<Pagination><MedlinePgn>401-16</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">A primary objective of the study was to evaluate how food as well as a specific enhancer or an inhibitor of iron uptake affect erythrocyte iron uptake after oral administration of iron(III)-hydroxide polymaltose complex (IPC, Maltofer) in subjects with or without iron deficiency. Secondary objectives of the study were 1. to compare the uptake of 59Fe in erythrocytes between subjects with or without iron deficiency, 2. to evaluate the 59Fe activity in plasma after oral administration of IPC and 3. to evaluate the safety of oral administration of IPC by adverse events (AEs), vital signs, and hematological and clinical chemistry parameters.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Single-centre study with a crossover design. Each subject participated in two periods where single doses of 100 mg iron as IPC labeled with 59Fe were administered. In one period the subjects were fasting and in the other they were fed (Group A and Group B). Alternatively the study medication was administered in the fed state with an iron absorption enhancer (orange juice) or an iron absorption inhibitor (black tea, Group C and Group D). Eight subjects were included in each group, i.e. 32 subjects were included in total. All subjects completed the study and were included in the analyses of data.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In terms of relative incorporation of iron in erythrocytes, both subjects with and without iron deficiency benefited from the concomitant administration of an enhancer with the IPC. In iron deficiency subjects the iron uptake was improved when administered with food whereas for the normal subjects the uptake was greater during fasting conditions. The uptake of 59Fe in erythrocytes was greater in subjects with iron deficiency compared to the normal subjects, except when IPC was administered during fasting conditions. The safety assessments performed in this study did not demonstrate any unexpected observations or safety concerns with IPC.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In both subjects with and without iron deficiency treated with IPC the relative iron incorporation in erythrocytes increased in case of a concomitant administration of an enhancer. Furthermore, the 59Fe uptake in erythrocytes was higher in subjects with iron deficiency compared to normal subjects, except when IPC was administered during fasting conditions.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lundqvist</LastName>
<ForeName>Hans</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Radiation Sciences, Uppsala University, Uppsala, Sweden. Hans.Lundqvist@bms.uu.se</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sjöberg</LastName>
<ForeName>Folke</ForeName>
<Initials>F</Initials>
</Author>
</AuthorList>
<Language>ENG</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Arzneimittelforschung</MedlineTA>
<NlmUniqueID>0372660</NlmUniqueID>
<ISSNLinking>0004-4172</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005290">Ferric Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006454">Hemoglobins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007504">Iron Radioisotopes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013662">Tea</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014168">Transferrin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>E1UOL152H7</RegistryNumber>
<NameOfSubstance UI="D007501">Iron</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>UM5219H89V</RegistryNumber>
<NameOfSubstance UI="C013276">teferrol</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018798" MajorTopicYN="N">Anemia, Iron-Deficiency</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001628" MajorTopicYN="N">Beverages</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032084" MajorTopicYN="Y">Citrus sinensis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018592" MajorTopicYN="N">Cross-Over Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003627" MajorTopicYN="N">Data Interpretation, Statistical</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004912" MajorTopicYN="N">Erythrocytes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005290" MajorTopicYN="N">Ferric Compounds</DescriptorName>
<QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018565" MajorTopicYN="Y">Food-Drug Interactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006454" MajorTopicYN="N">Hemoglobins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007501" MajorTopicYN="N">Iron</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007504" MajorTopicYN="N">Iron Radioisotopes</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013662" MajorTopicYN="Y">Tea</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014168" MajorTopicYN="N">Transferrin</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year>
<Month>8</Month>
<Day>19</Day>
<Hour>9</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2007</Year>
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<Day>12</Day>
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<ArticleId IdType="doi">10.1055/s-0031-1296689</ArticleId>
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Food interaction of oral uptake of iron / a clinical trial using 59Fe.

Food interaction of oral uptake of iron / a clinical trial using 59Fe.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki