SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model
Identifieur interne : 002857 ( Main/Exploration ); précédent : 002856; suivant : 002858SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model
Auteurs : Stergios Tsartsalis [Suisse] ; Noé Dumas ; Benjamin B. Tournier ; Tien Pham ; Marcelle Moulin-Sallanon [France] ; Marie-Claude Grégoire ; Yves Charnay ; Philippe MilletSource :
- EJNMMI Research [ 2191-219X ] ; 2015.
Abstract
Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse glioma using radioiodinated CLINDE, a TSPO-specific tracer.
GL26 cells, previously transfected with an enhanced green fluorescent protein (EGFP)-expressing lentivirus, were stereotactically implanted in the striatum of C57/Bl6 mice. At 4 weeks post-injection, dynamic SPECT scans with [123I]CLINDE were performed. A displacement study assessed specificity of tracer binding. SPECT images were compared to results of autoradiography, fluorescence microscopy,
Specific uptake of tracer by the tumor is observed with a high signal-to-noise ratio. Tracer uptake by the tumor is indeed 3.26 ± 0.32 times higher than that of the contralateral striatum, and 78% of the activity is displaceable by unlabeled CLINDE. Finally, TSPO is abundantly expressed by the GL26 cells.
The present study demonstrates the feasibility of [123I]CLINDE SPECT in translational studies and underlines its potential for clinical glioma SPECT imaging.
Url:
DOI: 10.1186/s13550-015-0092-4
PubMed: 25853015
PubMed Central: 4385259
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B78
- to stream Pmc, to step Curation: 000B55
- to stream Pmc, to step Checkpoint: 000D30
- to stream PubMed, to step Corpus: 002F14
- to stream PubMed, to step Curation: 002E36
- to stream PubMed, to step Checkpoint: 002E36
- to stream Ncbi, to step Merge: 002427
- to stream Ncbi, to step Curation: 002427
- to stream Ncbi, to step Checkpoint: 002427
- to stream Main, to step Merge: 002857
- to stream Main, to step Curation: 002857
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model</title><author><name sortKey="Tsartsalis, Stergios" sort="Tsartsalis, Stergios" uniqKey="Tsartsalis S" first="Stergios" last="Tsartsalis">Stergios Tsartsalis</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Psychiatry, University of Geneva, 1 rue Michel-Servet, CH1211 Geneva 4, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Psychiatry, University of Geneva, 1 rue Michel-Servet, CH1211 Geneva 4</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Dumas, Noe" sort="Dumas, Noe" uniqKey="Dumas N" first="Noé" last="Dumas">Noé Dumas</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation></author><author><name sortKey="Tournier, Benjamin B" sort="Tournier, Benjamin B" uniqKey="Tournier B" first="Benjamin B" last="Tournier">Benjamin B. Tournier</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation></author><author><name sortKey="Pham, Tien" sort="Pham, Tien" uniqKey="Pham T" first="Tien" last="Pham">Tien Pham</name><affiliation><nlm:aff id="Aff3">ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2234 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Moulin Sallanon, Marcelle" sort="Moulin Sallanon, Marcelle" uniqKey="Moulin Sallanon M" first="Marcelle" last="Moulin-Sallanon">Marcelle Moulin-Sallanon</name><affiliation wicri:level="1"><nlm:aff id="Aff4">INSERM, J. Fourier University, INSERM Unit 1039, Domaine de la Merci, 38700 La Tronche, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, J. Fourier University, INSERM Unit 1039, Domaine de la Merci, 38700 La Tronche</wicri:regionArea><wicri:noRegion>38700 La Tronche</wicri:noRegion><wicri:noRegion>38700 La Tronche</wicri:noRegion></affiliation></author><author><name sortKey="Gregoire, Marie Claude" sort="Gregoire, Marie Claude" uniqKey="Gregoire M" first="Marie-Claude" last="Grégoire">Marie-Claude Grégoire</name><affiliation><nlm:aff id="Aff3">ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2234 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Charnay, Yves" sort="Charnay, Yves" uniqKey="Charnay Y" first="Yves" last="Charnay">Yves Charnay</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation></author><author><name sortKey="Millet, Philippe" sort="Millet, Philippe" uniqKey="Millet P" first="Philippe" last="Millet">Philippe Millet</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25853015</idno><idno type="pmc">4385259</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385259</idno><idno type="RBID">PMC:4385259</idno><idno type="doi">10.1186/s13550-015-0092-4</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000B78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B78</idno><idno type="wicri:Area/Pmc/Curation">000B55</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B55</idno><idno type="wicri:Area/Pmc/Checkpoint">000D30</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D30</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002F14</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002F14</idno><idno type="wicri:Area/PubMed/Curation">002E36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002E36</idno><idno type="wicri:Area/PubMed/Checkpoint">002E36</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002E36</idno><idno type="wicri:Area/Ncbi/Merge">002427</idno><idno type="wicri:Area/Ncbi/Curation">002427</idno><idno type="wicri:Area/Ncbi/Checkpoint">002427</idno><idno type="wicri:Area/Main/Merge">002857</idno><idno type="wicri:Area/Main/Curation">002857</idno><idno type="wicri:Area/Main/Exploration">002857</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model</title><author><name sortKey="Tsartsalis, Stergios" sort="Tsartsalis, Stergios" uniqKey="Tsartsalis S" first="Stergios" last="Tsartsalis">Stergios Tsartsalis</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Psychiatry, University of Geneva, 1 rue Michel-Servet, CH1211 Geneva 4, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Psychiatry, University of Geneva, 1 rue Michel-Servet, CH1211 Geneva 4</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Dumas, Noe" sort="Dumas, Noe" uniqKey="Dumas N" first="Noé" last="Dumas">Noé Dumas</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation></author><author><name sortKey="Tournier, Benjamin B" sort="Tournier, Benjamin B" uniqKey="Tournier B" first="Benjamin B" last="Tournier">Benjamin B. Tournier</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation></author><author><name sortKey="Pham, Tien" sort="Pham, Tien" uniqKey="Pham T" first="Tien" last="Pham">Tien Pham</name><affiliation><nlm:aff id="Aff3">ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2234 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Moulin Sallanon, Marcelle" sort="Moulin Sallanon, Marcelle" uniqKey="Moulin Sallanon M" first="Marcelle" last="Moulin-Sallanon">Marcelle Moulin-Sallanon</name><affiliation wicri:level="1"><nlm:aff id="Aff4">INSERM, J. Fourier University, INSERM Unit 1039, Domaine de la Merci, 38700 La Tronche, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, J. Fourier University, INSERM Unit 1039, Domaine de la Merci, 38700 La Tronche</wicri:regionArea><wicri:noRegion>38700 La Tronche</wicri:noRegion><wicri:noRegion>38700 La Tronche</wicri:noRegion></affiliation></author><author><name sortKey="Gregoire, Marie Claude" sort="Gregoire, Marie Claude" uniqKey="Gregoire M" first="Marie-Claude" last="Grégoire">Marie-Claude Grégoire</name><affiliation><nlm:aff id="Aff3">ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2234 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Charnay, Yves" sort="Charnay, Yves" uniqKey="Charnay Y" first="Yves" last="Charnay">Yves Charnay</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation></author><author><name sortKey="Millet, Philippe" sort="Millet, Philippe" uniqKey="Millet P" first="Philippe" last="Millet">Philippe Millet</name><affiliation><nlm:aff id="Aff1">Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland</nlm:aff><wicri:noCountry code="subfield">Chêne-Bourg Switzerland</wicri:noCountry></affiliation></author></analytic><series><title level="j">EJNMMI Research</title><idno type="eISSN">2191-219X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse glioma using radioiodinated CLINDE, a TSPO-specific tracer.</p></sec><sec><title>Methods</title><p>GL26 cells, previously transfected with an enhanced green fluorescent protein (EGFP)-expressing lentivirus, were stereotactically implanted in the striatum of C57/Bl6 mice. At 4 weeks post-injection, dynamic SPECT scans with [<sup>123</sup>I]CLINDE were performed. A displacement study assessed specificity of tracer binding. SPECT images were compared to results of autoradiography, fluorescence microscopy, <italic>in situ</italic> nucleic acid hybridization, histology, and immunohistochemistry. Western blotting was performed to verify TSPO production by the tumor.</p></sec><sec><title>Results</title><p>Specific uptake of tracer by the tumor is observed with a high signal-to-noise ratio. Tracer uptake by the tumor is indeed 3.26 ± 0.32 times higher than that of the contralateral striatum, and 78% of the activity is displaceable by unlabeled CLINDE. Finally, TSPO is abundantly expressed by the GL26 cells.</p></sec><sec><title>Conclusions</title><p>The present study demonstrates the feasibility of [<sup>123</sup>I]CLINDE SPECT in translational studies and underlines its potential for clinical glioma SPECT imaging.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Scarf, Am" uniqKey="Scarf A">AM Scarf</name></author><author><name sortKey="Kassiou, M" uniqKey="Kassiou M">M Kassiou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winkeler, A" uniqKey="Winkeler A">A Winkeler</name></author><author><name sortKey="Boisgard, R" uniqKey="Boisgard R">R Boisgard</name></author><author><name sortKey="Awde, Ar" uniqKey="Awde A">AR Awde</name></author><author><name sortKey="Dubois, A" uniqKey="Dubois A">A Dubois</name></author><author><name sortKey="Theze, B" uniqKey="Theze B">B Theze</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, D" uniqKey="Tang D">D Tang</name></author><author><name sortKey="Hight, Mr" uniqKey="Hight M">MR Hight</name></author><author><name sortKey="Mckinley, Et" uniqKey="Mckinley E">ET McKinley</name></author><author><name sortKey="Fu, A" uniqKey="Fu A">A Fu</name></author><author><name sortKey="Buck, Jr" uniqKey="Buck J">JR Buck</name></author><author><name sortKey="Smith, Ra" uniqKey="Smith R">RA Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, Z" uniqKey="Su Z">Z Su</name></author><author><name sortKey="Herholz, K" uniqKey="Herholz K">K Herholz</name></author><author><name sortKey="Gerhard, A" uniqKey="Gerhard A">A Gerhard</name></author><author><name sortKey="Roncaroli, F" uniqKey="Roncaroli F">F Roncaroli</name></author><author><name sortKey="Du Plessis, D" uniqKey="Du Plessis D">D Du Plessis</name></author><author><name sortKey="Jackson, A" uniqKey="Jackson A">A Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattner, F" uniqKey="Mattner F">F Mattner</name></author><author><name sortKey="Bandin, Dl" uniqKey="Bandin D">DL Bandin</name></author><author><name sortKey="Staykova, M" uniqKey="Staykova M">M Staykova</name></author><author><name sortKey="Berghofer, P" uniqKey="Berghofer P">P Berghofer</name></author><author><name sortKey="Gregoire, Mc" uniqKey="Gregoire M">MC Gregoire</name></author><author><name sortKey="Ballantyne, P" uniqKey="Ballantyne P">P Ballantyne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattner, F" uniqKey="Mattner F">F Mattner</name></author><author><name sortKey="Mardon, K" uniqKey="Mardon K">K Mardon</name></author><author><name sortKey="Katsifis, A" uniqKey="Katsifis A">A Katsifis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mattner, F" uniqKey="Mattner F">F Mattner</name></author><author><name sortKey="Katsifis, A" uniqKey="Katsifis A">A Katsifis</name></author><author><name sortKey="Staykova, M" uniqKey="Staykova M">M Staykova</name></author><author><name sortKey="Ballantyne, P" uniqKey="Ballantyne P">P Ballantyne</name></author><author><name sortKey="Willenborg, Do" uniqKey="Willenborg D">DO Willenborg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schiffer, Wk" uniqKey="Schiffer W">WK Schiffer</name></author><author><name sortKey="Mirrione, Mm" uniqKey="Mirrione M">MM Mirrione</name></author><author><name sortKey="Biegon, A" uniqKey="Biegon A">A Biegon</name></author><author><name sortKey="Alexoff, Dl" uniqKey="Alexoff D">DL Alexoff</name></author><author><name sortKey="Patel, V" uniqKey="Patel V">V Patel</name></author><author><name sortKey="Dewey, Sl" uniqKey="Dewey S">SL Dewey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charnay, Y" uniqKey="Charnay Y">Y Charnay</name></author><author><name sortKey="Imhof, A" uniqKey="Imhof A">A Imhof</name></author><author><name sortKey="Vallet, Pg" uniqKey="Vallet P">PG Vallet</name></author><author><name sortKey="Hakkoum, D" uniqKey="Hakkoum D">D Hakkoum</name></author><author><name sortKey="Lathuiliere, A" uniqKey="Lathuiliere A">A Lathuiliere</name></author><author><name sortKey="Poku, N" uniqKey="Poku N">N Poku</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imhof, A" uniqKey="Imhof A">A Imhof</name></author><author><name sortKey="Charnay, Y" uniqKey="Charnay Y">Y Charnay</name></author><author><name sortKey="Vallet, Pg" uniqKey="Vallet P">PG Vallet</name></author><author><name sortKey="Aronow, B" uniqKey="Aronow B">B Aronow</name></author><author><name sortKey="Kovari, E" uniqKey="Kovari E">E Kovari</name></author><author><name sortKey="French, Le" uniqKey="French L">LE French</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Batarseh, A" uniqKey="Batarseh A">A Batarseh</name></author><author><name sortKey="Papadopoulos, V" uniqKey="Papadopoulos V">V Papadopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buck, Jr" uniqKey="Buck J">JR Buck</name></author><author><name sortKey="Mckinley, Et" uniqKey="Mckinley E">ET McKinley</name></author><author><name sortKey="Hight, Mr" uniqKey="Hight M">MR Hight</name></author><author><name sortKey="Fu, A" uniqKey="Fu A">A Fu</name></author><author><name sortKey="Tang, D" uniqKey="Tang D">D Tang</name></author><author><name sortKey="Smith, Ra" uniqKey="Smith R">RA Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, Ah" uniqKey="Shah A">AH Shah</name></author><author><name sortKey="Snelling, B" uniqKey="Snelling B">B Snelling</name></author><author><name sortKey="Bregy, A" uniqKey="Bregy A">A Bregy</name></author><author><name sortKey="Patel, Pr" uniqKey="Patel P">PR Patel</name></author><author><name sortKey="Tememe, D" uniqKey="Tememe D">D Tememe</name></author><author><name sortKey="Bhatia, R" uniqKey="Bhatia R">R Bhatia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Ma, L" uniqKey="Ma L">L Ma</name></author><author><name sortKey="Wu, C" uniqKey="Wu C">C Wu</name></author><author><name sortKey="Xu, B" uniqKey="Xu B">B Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Awde, Ar" uniqKey="Awde A">AR Awde</name></author><author><name sortKey="Boisgard, R" uniqKey="Boisgard R">R Boisgard</name></author><author><name sortKey="Theze, B" uniqKey="Theze B">B Theze</name></author><author><name sortKey="Dubois, A" uniqKey="Dubois A">A Dubois</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J Zheng</name></author><author><name sortKey="Dolle, F" uniqKey="Dolle F">F Dolle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, Z" uniqKey="Su Z">Z Su</name></author><author><name sortKey="Gerhard, A" uniqKey="Gerhard A">A Gerhard</name></author><author><name sortKey="Hinz, R" uniqKey="Hinz R">R Hinz</name></author><author><name sortKey="Coope, Dj" uniqKey="Coope D">DJ Coope</name></author><author><name sortKey="Thompson, G" uniqKey="Thompson G">G Thompson</name></author><author><name sortKey="Karabatsou, K" uniqKey="Karabatsou K">K Karabatsou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meikle, Sr" uniqKey="Meikle S">SR Meikle</name></author><author><name sortKey="Kench, P" uniqKey="Kench P">P Kench</name></author><author><name sortKey="Kassiou, M" uniqKey="Kassiou M">M Kassiou</name></author><author><name sortKey="Banati, Rb" uniqKey="Banati R">RB Banati</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Suisse</li></country><region><li>Canton de Genève</li></region><settlement><li>Genève</li></settlement><orgName><li>Université de Genève</li></orgName></list><tree><noCountry><name sortKey="Charnay, Yves" sort="Charnay, Yves" uniqKey="Charnay Y" first="Yves" last="Charnay">Yves Charnay</name><name sortKey="Dumas, Noe" sort="Dumas, Noe" uniqKey="Dumas N" first="Noé" last="Dumas">Noé Dumas</name><name sortKey="Gregoire, Marie Claude" sort="Gregoire, Marie Claude" uniqKey="Gregoire M" first="Marie-Claude" last="Grégoire">Marie-Claude Grégoire</name><name sortKey="Millet, Philippe" sort="Millet, Philippe" uniqKey="Millet P" first="Philippe" last="Millet">Philippe Millet</name><name sortKey="Pham, Tien" sort="Pham, Tien" uniqKey="Pham T" first="Tien" last="Pham">Tien Pham</name><name sortKey="Tournier, Benjamin B" sort="Tournier, Benjamin B" uniqKey="Tournier B" first="Benjamin B" last="Tournier">Benjamin B. Tournier</name></noCountry><country name="Suisse"><region name="Canton de Genève"><name sortKey="Tsartsalis, Stergios" sort="Tsartsalis, Stergios" uniqKey="Tsartsalis S" first="Stergios" last="Tsartsalis">Stergios Tsartsalis</name></region></country><country name="France"><noRegion><name sortKey="Moulin Sallanon, Marcelle" sort="Moulin Sallanon, Marcelle" uniqKey="Moulin Sallanon M" first="Marcelle" last="Moulin-Sallanon">Marcelle Moulin-Sallanon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002857 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002857 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4385259
|texte= SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25853015" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |