SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model.
Identifieur interne : 002F14 ( PubMed/Corpus ); précédent : 002F13; suivant : 002F15SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model.
Auteurs : Stergios Tsartsalis ; Noé Dumas ; Benjamin B. Tournier ; Tien Pham ; Marcelle Moulin-Sallanon ; Marie-Claude Grégoire ; Yves Charnay ; Philippe MilletSource :
- EJNMMI research [ 2191-219X ] ; 2015.
Abstract
Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse glioma using radioiodinated CLINDE, a TSPO-specific tracer.
DOI: 10.1186/s13550-015-0092-4
PubMed: 25853015
Links to Exploration step
pubmed:25853015Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model.</title><author><name sortKey="Tsartsalis, Stergios" sort="Tsartsalis, Stergios" uniqKey="Tsartsalis S" first="Stergios" last="Tsartsalis">Stergios Tsartsalis</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland ; Department of Psychiatry, University of Geneva, 1 rue Michel-Servet, CH1211 Geneva 4, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Dumas, Noe" sort="Dumas, Noe" uniqKey="Dumas N" first="Noé" last="Dumas">Noé Dumas</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Tournier, Benjamin B" sort="Tournier, Benjamin B" uniqKey="Tournier B" first="Benjamin B" last="Tournier">Benjamin B. Tournier</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Pham, Tien" sort="Pham, Tien" uniqKey="Pham T" first="Tien" last="Pham">Tien Pham</name><affiliation><nlm:affiliation>ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Moulin Sallanon, Marcelle" sort="Moulin Sallanon, Marcelle" uniqKey="Moulin Sallanon M" first="Marcelle" last="Moulin-Sallanon">Marcelle Moulin-Sallanon</name><affiliation><nlm:affiliation>INSERM, J. Fourier University, INSERM Unit 1039, Domaine de la Merci, 38700 La Tronche, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gregoire, Marie Claude" sort="Gregoire, Marie Claude" uniqKey="Gregoire M" first="Marie-Claude" last="Grégoire">Marie-Claude Grégoire</name><affiliation><nlm:affiliation>ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Charnay, Yves" sort="Charnay, Yves" uniqKey="Charnay Y" first="Yves" last="Charnay">Yves Charnay</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Millet, Philippe" sort="Millet, Philippe" uniqKey="Millet P" first="Philippe" last="Millet">Philippe Millet</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25853015</idno><idno type="pmid">25853015</idno><idno type="doi">10.1186/s13550-015-0092-4</idno><idno type="wicri:Area/PubMed/Corpus">002F14</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002F14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model.</title><author><name sortKey="Tsartsalis, Stergios" sort="Tsartsalis, Stergios" uniqKey="Tsartsalis S" first="Stergios" last="Tsartsalis">Stergios Tsartsalis</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland ; Department of Psychiatry, University of Geneva, 1 rue Michel-Servet, CH1211 Geneva 4, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Dumas, Noe" sort="Dumas, Noe" uniqKey="Dumas N" first="Noé" last="Dumas">Noé Dumas</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Tournier, Benjamin B" sort="Tournier, Benjamin B" uniqKey="Tournier B" first="Benjamin B" last="Tournier">Benjamin B. Tournier</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Pham, Tien" sort="Pham, Tien" uniqKey="Pham T" first="Tien" last="Pham">Tien Pham</name><affiliation><nlm:affiliation>ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Moulin Sallanon, Marcelle" sort="Moulin Sallanon, Marcelle" uniqKey="Moulin Sallanon M" first="Marcelle" last="Moulin-Sallanon">Marcelle Moulin-Sallanon</name><affiliation><nlm:affiliation>INSERM, J. Fourier University, INSERM Unit 1039, Domaine de la Merci, 38700 La Tronche, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gregoire, Marie Claude" sort="Gregoire, Marie Claude" uniqKey="Gregoire M" first="Marie-Claude" last="Grégoire">Marie-Claude Grégoire</name><affiliation><nlm:affiliation>ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Charnay, Yves" sort="Charnay, Yves" uniqKey="Charnay Y" first="Yves" last="Charnay">Yves Charnay</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Millet, Philippe" sort="Millet, Philippe" uniqKey="Millet P" first="Philippe" last="Millet">Philippe Millet</name><affiliation><nlm:affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">EJNMMI research</title><idno type="ISSN">2191-219X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse glioma using radioiodinated CLINDE, a TSPO-specific tracer.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">25853015</PMID><DateCreated><Year>2015</Year><Month>04</Month><Day>08</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2191-219X</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>EJNMMI research</Title><ISOAbbreviation>EJNMMI Res</ISOAbbreviation></Journal><ArticleTitle>SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model.</ArticleTitle><Pagination><MedlinePgn>9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13550-015-0092-4</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse glioma using radioiodinated CLINDE, a TSPO-specific tracer.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">GL26 cells, previously transfected with an enhanced green fluorescent protein (EGFP)-expressing lentivirus, were stereotactically implanted in the striatum of C57/Bl6 mice. At 4 weeks post-injection, dynamic SPECT scans with [(123)I]CLINDE were performed. A displacement study assessed specificity of tracer binding. SPECT images were compared to results of autoradiography, fluorescence microscopy, in situ nucleic acid hybridization, histology, and immunohistochemistry. Western blotting was performed to verify TSPO production by the tumor.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Specific uptake of tracer by the tumor is observed with a high signal-to-noise ratio. Tracer uptake by the tumor is indeed 3.26 ± 0.32 times higher than that of the contralateral striatum, and 78% of the activity is displaceable by unlabeled CLINDE. Finally, TSPO is abundantly expressed by the GL26 cells.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The present study demonstrates the feasibility of [(123)I]CLINDE SPECT in translational studies and underlines its potential for clinical glioma SPECT imaging.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tsartsalis</LastName><ForeName>Stergios</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland ; Department of Psychiatry, University of Geneva, 1 rue Michel-Servet, CH1211 Geneva 4, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dumas</LastName><ForeName>Noé</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tournier</LastName><ForeName>Benjamin B</ForeName><Initials>BB</Initials><AffiliationInfo><Affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pham</LastName><ForeName>Tien</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moulin-Sallanon</LastName><ForeName>Marcelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM, J. Fourier University, INSERM Unit 1039, Domaine de la Merci, 38700 La Tronche, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grégoire</LastName><ForeName>Marie-Claude</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234 Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Charnay</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Millet</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Vulnerability Biomarkers Unit, Division of General Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Chemin du Petit-Bel-Air 2, CH1225 Geneva, Chêne-Bourg Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>EJNMMI Res</MedlineTA><NlmUniqueID>101560946</NlmUniqueID></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2006 May;22(2):274-83</RefSource><PMID Version="1">16473512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Phys Med Biol. 2005 Nov 21;50(22):R45-61</RefSource><PMID Version="1">16264248</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2008 Aug 26;155(3):714-24</RefSource><PMID Version="1">18620027</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2012 Feb;53(2):287-94</RefSource><PMID Version="1">22251555</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2012 May;39(5):811-23</RefSource><PMID Version="1">22270507</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2011 Aug;38(8):1516-28</RefSource><PMID Version="1">21484375</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2013 Dec;54(12 ):2125-31</RefSource><PMID Version="1">24212976</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2011 Jan;52(1):107-14</RefSource><PMID Version="1">21149488</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2005 May;32(5):557-63</RefSource><PMID Version="1">15875181</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Neurosci. 2015 Feb;22(2):229-37</RefSource><PMID Version="1">25443083</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Endocrinol. 2010 Oct 7;327(1-2):1-12</RefSource><PMID Version="1">20600583</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Methods. 2006 Sep 15;155(2):272-84</RefSource><PMID Version="1">16519945</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2011 May;52(5):677-80</RefSource><PMID Version="1">21498529</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2013 Sep;40(9):1406-19</RefSource><PMID Version="1">23715902</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2008 Apr;35(4):779-89</RefSource><PMID Version="1">18057934</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurooncol. 2013 Apr;112(2):141-52</RefSource><PMID Version="1">23344789</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2007 Sep;48(9):1468-81</RefSource><PMID Version="1">17704239</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC4385259</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CLINDE</Keyword><Keyword MajorTopicYN="N">Glioma</Keyword><Keyword MajorTopicYN="N">SPECT</Keyword><Keyword MajorTopicYN="N">TSPO</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25853015</ArticleId><ArticleId IdType="doi">10.1186/s13550-015-0092-4</ArticleId><ArticleId IdType="pii">92</ArticleId><ArticleId IdType="pmc">PMC4385259</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F14 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002F14 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:25853015
|texte= SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25853015" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |