SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model
Identifieur interne : 002427 ( Ncbi/Checkpoint ); précédent : 002426; suivant : 002428SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model
Auteurs : Stergios Tsartsalis [Suisse] ; Noé Dumas ; Benjamin B. Tournier ; Tien Pham ; Marcelle Moulin-Sallanon [France] ; Marie-Claude Grégoire ; Yves Charnay ; Philippe MilletSource :
- EJNMMI Research [ 2191-219X ] ; 2015.
Abstract
Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse glioma using radioiodinated CLINDE, a TSPO-specific tracer.
GL26 cells, previously transfected with an enhanced green fluorescent protein (EGFP)-expressing lentivirus, were stereotactically implanted in the striatum of C57/Bl6 mice. At 4 weeks post-injection, dynamic SPECT scans with [123I]CLINDE were performed. A displacement study assessed specificity of tracer binding. SPECT images were compared to results of autoradiography, fluorescence microscopy,
Specific uptake of tracer by the tumor is observed with a high signal-to-noise ratio. Tracer uptake by the tumor is indeed 3.26 ± 0.32 times higher than that of the contralateral striatum, and 78% of the activity is displaceable by unlabeled CLINDE. Finally, TSPO is abundantly expressed by the GL26 cells.
The present study demonstrates the feasibility of [123I]CLINDE SPECT in translational studies and underlines its potential for clinical glioma SPECT imaging.
Url:
DOI: 10.1186/s13550-015-0092-4
PubMed: 25853015
PubMed Central: 4385259
Affiliations:
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse glioma using radioiodinated CLINDE, a TSPO-specific tracer.</p>
</sec>
<sec><title>Methods</title>
<p>GL26 cells, previously transfected with an enhanced green fluorescent protein (EGFP)-expressing lentivirus, were stereotactically implanted in the striatum of C57/Bl6 mice. At 4 weeks post-injection, dynamic SPECT scans with [<sup>123</sup>
I]CLINDE were performed. A displacement study assessed specificity of tracer binding. SPECT images were compared to results of autoradiography, fluorescence microscopy, <italic>in situ</italic>
nucleic acid hybridization, histology, and immunohistochemistry. Western blotting was performed to verify TSPO production by the tumor.</p>
</sec>
<sec><title>Results</title>
<p>Specific uptake of tracer by the tumor is observed with a high signal-to-noise ratio. Tracer uptake by the tumor is indeed 3.26 ± 0.32 times higher than that of the contralateral striatum, and 78% of the activity is displaceable by unlabeled CLINDE. Finally, TSPO is abundantly expressed by the GL26 cells.</p>
</sec>
<sec><title>Conclusions</title>
<p>The present study demonstrates the feasibility of [<sup>123</sup>
I]CLINDE SPECT in translational studies and underlines its potential for clinical glioma SPECT imaging.</p>
</sec>
</div>
</front>
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<author><name sortKey="Kassiou, M" uniqKey="Kassiou M">M Kassiou</name>
</author>
<author><name sortKey="Banati, Rb" uniqKey="Banati R">RB Banati</name>
</author>
</analytic>
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</TEI>
<affiliations><list><country><li>France</li>
<li>Suisse</li>
</country>
<region><li>Canton de Genève</li>
</region>
<settlement><li>Genève</li>
</settlement>
<orgName><li>Université de Genève</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Charnay, Yves" sort="Charnay, Yves" uniqKey="Charnay Y" first="Yves" last="Charnay">Yves Charnay</name>
<name sortKey="Dumas, Noe" sort="Dumas, Noe" uniqKey="Dumas N" first="Noé" last="Dumas">Noé Dumas</name>
<name sortKey="Gregoire, Marie Claude" sort="Gregoire, Marie Claude" uniqKey="Gregoire M" first="Marie-Claude" last="Grégoire">Marie-Claude Grégoire</name>
<name sortKey="Millet, Philippe" sort="Millet, Philippe" uniqKey="Millet P" first="Philippe" last="Millet">Philippe Millet</name>
<name sortKey="Pham, Tien" sort="Pham, Tien" uniqKey="Pham T" first="Tien" last="Pham">Tien Pham</name>
<name sortKey="Tournier, Benjamin B" sort="Tournier, Benjamin B" uniqKey="Tournier B" first="Benjamin B" last="Tournier">Benjamin B. Tournier</name>
</noCountry>
<country name="Suisse"><region name="Canton de Genève"><name sortKey="Tsartsalis, Stergios" sort="Tsartsalis, Stergios" uniqKey="Tsartsalis S" first="Stergios" last="Tsartsalis">Stergios Tsartsalis</name>
</region>
</country>
<country name="France"><noRegion><name sortKey="Moulin Sallanon, Marcelle" sort="Moulin Sallanon, Marcelle" uniqKey="Moulin Sallanon M" first="Marcelle" last="Moulin-Sallanon">Marcelle Moulin-Sallanon</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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