Ouabain and digitoxin as modulators of chick embryo cardiomyocyte energy metabolism
Identifieur interne : 002E80 ( Main/Exploration ); précédent : 002E79; suivant : 002E81Ouabain and digitoxin as modulators of chick embryo cardiomyocyte energy metabolism
Auteurs : M. Riehle [Allemagne] ; J. Bereiter-HahnSource :
- Arzneimittel-Forschung [ 0004-4172 ] ; 1994.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The effects of 0.1 nmol/l ouabain (CAS 630-60-4) and digitoxin (CAS 71-63-6) on oxygen consumption rate (OCR) and the contractility of cultured chick embryo cardiomyocytes were investigated using a perfusion system which allowed microscopic observation during the experiment. Contractility was assessed by a novel image analysis procedure. During substrate free perfusion the OCR was increased on application of 0.1 nmol/l ouabain or digitoxin for 60 min, whilst contractility was not affected
Affiliations:
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Le document en format XML
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<s2>Frankfurt/Main</s2>
<s3>DEU</s3>
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<country>Allemagne</country>
<wicri:noRegion>Frankfurt/Main</wicri:noRegion>
<wicri:noRegion>cinematic cell res. group</wicri:noRegion>
<wicri:noRegion>Frankfurt/Main</wicri:noRegion>
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<author><name sortKey="Bereiter Hahn, J" sort="Bereiter Hahn, J" uniqKey="Bereiter Hahn J" first="J." last="Bereiter-Hahn">J. Bereiter-Hahn</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Ouabain and digitoxin as modulators of chick embryo cardiomyocyte energy metabolism</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Cardiotonic agent</term>
<term>Cell culture</term>
<term>Chicken</term>
<term>Circulatory system</term>
<term>Contractility</term>
<term>Embryo</term>
<term>Glycoside</term>
<term>Heart</term>
<term>In vitro</term>
<term>Metabolism</term>
<term>Myocyte</term>
<term>Oxygen consumption</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ouabaïne</term>
<term>Digitoxine</term>
<term>Cardiotonique</term>
<term>Coeur</term>
<term>Appareil circulatoire</term>
<term>Consommation oxygène</term>
<term>Métabolisme</term>
<term>Embryon</term>
<term>Contractilité</term>
<term>Myocyte</term>
<term>Culture cellulaire</term>
<term>Poulet</term>
<term>In vitro</term>
<term>Glycoside</term>
<term>Animal</term>
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<front><div type="abstract" xml:lang="en">The effects of 0.1 nmol/l ouabain (CAS 630-60-4) and digitoxin (CAS 71-63-6) on oxygen consumption rate (OCR) and the contractility of cultured chick embryo cardiomyocytes were investigated using a perfusion system which allowed microscopic observation during the experiment. Contractility was assessed by a novel image analysis procedure. During substrate free perfusion the OCR was increased on application of 0.1 nmol/l ouabain or digitoxin for 60 min, whilst contractility was not affected</div>
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