Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver
Identifieur interne : 002A32 ( Main/Exploration ); précédent : 002A31; suivant : 002A33Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver
Auteurs : Viswanathan Seshan [États-Unis] ; A. Dean Sherry [États-Unis] ; Navin Bansal [États-Unis]Source :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 1997-11.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Animals, Bansal, Biexponential relaxation, Binding sites, Biological cations, Biological tissue, Blood cells, Blood flow, Bottom panel, Data point, Dysprosium shift reagents, Error bars, Evolution time, Extracellular, Fourier transformation, Global ischemia, Infusion, Intra, Intracellular, Intracellular sodium, Ischemia, Large percent increase, Line shape, Liver (metabolism), Liver signal, Macromolecule, Magn, Magnetic Resonance Spectroscopy (methods), Male, Malloy, Mary nell, Medical center, Methylene phosphonate, Multiple quantum, Naif, Naif signal, Nait signal, Nait signal intensity, Navin bansal, Normal saline, Organometallic Compounds, Organophosphorus Compounds, Peak areas, Perfused, Perfused liver, Postmortem, Preparation delay, Preparation time, Rabbit kidney, Rats, Rats, Sprague-Dawley, Reagent, Reference bulb, Relative change, Relative changes, Relative increase, Relaxation, Relaxation times, Reson, Resonance center, Resonance frequency, Respiratory motion, Right panel, Selective detection, Seshan, Shift reagent, Shift reagents, Signal intensities, Signal intensity, Significant change, Similar increases, Sodium (metabolism), Surface coil, Thulium, Tqfiltered, Transverse relaxation time, Transverse relaxation times, Triple quantum, True signal, Vivo.
- MESH :
- chemical , metabolism : Sodium.
- metabolism : Liver.
- methods : Magnetic Resonance Spectroscopy.
- Teeft :
- Animals, Bansal, Biexponential relaxation, Binding sites, Biological cations, Biological tissue, Blood cells, Blood flow, Bottom panel, Data point, Dysprosium shift reagents, Error bars, Evolution time, Extracellular, Fourier transformation, Global ischemia, Infusion, Intra, Intracellular, Intracellular sodium, Ischemia, Large percent increase, Line shape, Liver signal, Macromolecule, Magn, Male, Malloy, Mary nell, Medical center, Methylene phosphonate, Multiple quantum, Naif, Naif signal, Nait signal, Nait signal intensity, Navin bansal, Normal saline, Organometallic Compounds, Organophosphorus Compounds, Peak areas, Perfused, Perfused liver, Postmortem, Preparation delay, Preparation time, Rabbit kidney, Rats, Rats, Sprague-Dawley, Reagent, Reference bulb, Relative change, Relative changes, Relative increase, Relaxation, Relaxation times, Reson, Resonance center, Resonance frequency, Respiratory motion, Right panel, Selective detection, Seshan, Shift reagent, Shift reagents, Signal intensities, Signal intensity, Significant change, Similar increases, Surface coil, Thulium, Tqfiltered, Transverse relaxation time, Transverse relaxation times, Triple quantum, True signal, Vivo.
Abstract
Triple quantum (TQ)‐filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver, in situ. Nae+ contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+ increased by 90%. The constancy of the TQ‐filtered Nae+ signal indicates that changes in total TQ‐filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+ signal intensity. The large percent increase in the TQ‐filtered Nai+ signal as compared to the SQ signal suggests that the fraction of Nai+ interacting with macromolecules increases after death.
Url:
DOI: 10.1002/mrm.1910380519
Affiliations:
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Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Magnetic Resonance in Medicine</title><title level="j" type="alt">MAGNETIC RESONANCE IN MEDICINE</title><idno type="ISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><imprint><biblScope unit="vol">38</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="821">821</biblScope><biblScope unit="page" to="827">827</biblScope><biblScope unit="page-count">7</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Baltimore</pubPlace><date type="published" when="1997-11">1997-11</date></imprint><idno type="ISSN">0740-3194</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0740-3194</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bansal</term><term>Biexponential relaxation</term><term>Binding sites</term><term>Biological cations</term><term>Biological tissue</term><term>Blood cells</term><term>Blood flow</term><term>Bottom panel</term><term>Data point</term><term>Dysprosium shift reagents</term><term>Error bars</term><term>Evolution time</term><term>Extracellular</term><term>Fourier transformation</term><term>Global ischemia</term><term>Infusion</term><term>Intra</term><term>Intracellular</term><term>Intracellular sodium</term><term>Ischemia</term><term>Large percent increase</term><term>Line shape</term><term>Liver (metabolism)</term><term>Liver signal</term><term>Macromolecule</term><term>Magn</term><term>Magnetic Resonance Spectroscopy (methods)</term><term>Male</term><term>Malloy</term><term>Mary nell</term><term>Medical center</term><term>Methylene phosphonate</term><term>Multiple quantum</term><term>Naif</term><term>Naif signal</term><term>Nait signal</term><term>Nait signal intensity</term><term>Navin bansal</term><term>Normal saline</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Peak areas</term><term>Perfused</term><term>Perfused liver</term><term>Postmortem</term><term>Preparation delay</term><term>Preparation time</term><term>Rabbit kidney</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reagent</term><term>Reference bulb</term><term>Relative change</term><term>Relative changes</term><term>Relative increase</term><term>Relaxation</term><term>Relaxation times</term><term>Reson</term><term>Resonance center</term><term>Resonance frequency</term><term>Respiratory motion</term><term>Right panel</term><term>Selective detection</term><term>Seshan</term><term>Shift reagent</term><term>Shift reagents</term><term>Signal intensities</term><term>Signal intensity</term><term>Significant change</term><term>Similar increases</term><term>Sodium (metabolism)</term><term>Surface coil</term><term>Thulium</term><term>Tqfiltered</term><term>Transverse relaxation time</term><term>Transverse relaxation times</term><term>Triple quantum</term><term>True signal</term><term>Vivo</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Composés organiques du phosphore</term><term>Composés organométalliques</term><term>Foie (métabolisme)</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Sodium (métabolisme)</term><term>Spectroscopie par résonance magnétique ()</term><term>Thulium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Sodium</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Foie</term><term>Sodium</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Animals</term><term>Bansal</term><term>Biexponential relaxation</term><term>Binding sites</term><term>Biological cations</term><term>Biological tissue</term><term>Blood cells</term><term>Blood flow</term><term>Bottom panel</term><term>Data point</term><term>Dysprosium shift reagents</term><term>Error bars</term><term>Evolution time</term><term>Extracellular</term><term>Fourier transformation</term><term>Global ischemia</term><term>Infusion</term><term>Intra</term><term>Intracellular</term><term>Intracellular sodium</term><term>Ischemia</term><term>Large percent increase</term><term>Line shape</term><term>Liver signal</term><term>Macromolecule</term><term>Magn</term><term>Male</term><term>Malloy</term><term>Mary nell</term><term>Medical center</term><term>Methylene phosphonate</term><term>Multiple quantum</term><term>Naif</term><term>Naif signal</term><term>Nait signal</term><term>Nait signal intensity</term><term>Navin bansal</term><term>Normal saline</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Peak areas</term><term>Perfused</term><term>Perfused liver</term><term>Postmortem</term><term>Preparation delay</term><term>Preparation time</term><term>Rabbit kidney</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reagent</term><term>Reference bulb</term><term>Relative change</term><term>Relative changes</term><term>Relative increase</term><term>Relaxation</term><term>Relaxation times</term><term>Reson</term><term>Resonance center</term><term>Resonance frequency</term><term>Respiratory motion</term><term>Right panel</term><term>Selective detection</term><term>Seshan</term><term>Shift reagent</term><term>Shift reagents</term><term>Signal intensities</term><term>Signal intensity</term><term>Significant change</term><term>Similar increases</term><term>Surface coil</term><term>Thulium</term><term>Tqfiltered</term><term>Transverse relaxation time</term><term>Transverse relaxation times</term><term>Triple quantum</term><term>True signal</term><term>Vivo</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Composés organiques du phosphore</term><term>Composés organométalliques</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Spectroscopie par résonance magnétique</term><term>Thulium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Triple quantum (TQ)‐filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver, in situ. Nae+ contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+ increased by 90%. The constancy of the TQ‐filtered Nae+ signal indicates that changes in total TQ‐filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+ signal intensity. The large percent increase in the TQ‐filtered Nai+ signal as compared to the SQ signal suggests that the fraction of Nai+ interacting with macromolecules increases after death.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Seshan, Viswanathan" sort="Seshan, Viswanathan" uniqKey="Seshan V" first="Viswanathan" last="Seshan">Viswanathan Seshan</name></region><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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