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Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver.

Identifieur interne : 002B23 ( Main/Merge ); précédent : 002B22; suivant : 002B24

Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver.

Auteurs : V. Seshan [États-Unis] ; A D Sherry ; N. Bansal

Source :

Magnetic resonance in medicine [ 0740-3194 ] ; 1997.

RBID : pubmed:9358457

Descripteurs français

KwdFr :
- Animaux, Composés organiques du phosphore, Composés organométalliques, Foie (métabolisme), Mâle, Rat Sprague-Dawley, Rats, Sodium (métabolisme), Spectroscopie par résonance magnétique (), Thulium.
MESH :
- métabolisme : Foie, Sodium.
- Animaux, Composés organiques du phosphore, Composés organométalliques, Mâle, Rat Sprague-Dawley, Rats, Spectroscopie par résonance magnétique, Thulium.

English descriptors

KwdEn :
- Animals, Liver (metabolism), Magnetic Resonance Spectroscopy (methods), Male, Organometallic Compounds, Organophosphorus Compounds, Rats, Rats, Sprague-Dawley, Sodium (metabolism), Thulium.
MESH :
- chemical , metabolism : Sodium.
- chemical : Organometallic Compounds, Organophosphorus Compounds, Thulium.
- metabolism : Liver.
- methods : Magnetic Resonance Spectroscopy.
- Animals, Male, Rats, Rats, Sprague-Dawley.

Abstract

Triple quantum (TQ)-filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5-, have been used to evaluate the contributions of intra- (Na+i) and extracellular (Na+e) sodium to the TQ-filtered signal in the rat liver, in situ. Na+e contributed significantly to the total TQ-filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ-filtered Na+i signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Na+i increased by 90%. The constancy of the TQ-filtered Na+i signal indicates that changes in total TQ-filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ-filtered Na+i signal intensity. The large percent increase in the TQ-filtered Na+i signal as compared to the SQ signal suggests that the fraction of Na+i interacting with macromolecules increases after death.

PubMed: 9358457

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pubmed:9358457

Le document en format XML

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<author><name sortKey="Seshan, V" sort="Seshan, V" uniqKey="Seshan V" first="V" last="Seshan">V. Seshan</name>
<affiliation wicri:level="1"><nlm:affiliation>Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9085, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9085</wicri:regionArea>
<wicri:noRegion>Dallas 75235-9085</wicri:noRegion>
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<author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A D" last="Sherry">A D Sherry</name>
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<author><name sortKey="Bansal, N" sort="Bansal, N" uniqKey="Bansal N" first="N" last="Bansal">N. Bansal</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver.</title>
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<affiliation wicri:level="1"><nlm:affiliation>Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9085, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9085</wicri:regionArea>
<wicri:noRegion>Dallas 75235-9085</wicri:noRegion>
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<author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A D" last="Sherry">A D Sherry</name>
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<author><name sortKey="Bansal, N" sort="Bansal, N" uniqKey="Bansal N" first="N" last="Bansal">N. Bansal</name>
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<series><title level="j">Magnetic resonance in medicine</title>
<idno type="ISSN">0740-3194</idno>
<imprint><date when="1997" type="published">1997</date>
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<term>Liver (metabolism)</term>
<term>Magnetic Resonance Spectroscopy (methods)</term>
<term>Male</term>
<term>Organometallic Compounds</term>
<term>Organophosphorus Compounds</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Sodium (metabolism)</term>
<term>Thulium</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Composés organiques du phosphore</term>
<term>Composés organométalliques</term>
<term>Foie (métabolisme)</term>
<term>Mâle</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Sodium (métabolisme)</term>
<term>Spectroscopie par résonance magnétique ()</term>
<term>Thulium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Sodium</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Organometallic Compounds</term>
<term>Organophosphorus Compounds</term>
<term>Thulium</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Foie</term>
<term>Sodium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
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<term>Composés organiques du phosphore</term>
<term>Composés organométalliques</term>
<term>Mâle</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Thulium</term>
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<front><div type="abstract" xml:lang="en">Triple quantum (TQ)-filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5-, have been used to evaluate the contributions of intra- (Na+i) and extracellular (Na+e) sodium to the TQ-filtered signal in the rat liver, in situ. Na+e contributed significantly to the total TQ-filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ-filtered Na+i signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Na+i increased by 90%. The constancy of the TQ-filtered Na+i signal indicates that changes in total TQ-filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ-filtered Na+i signal intensity. The large percent increase in the TQ-filtered Na+i signal as compared to the SQ signal suggests that the fraction of Na+i interacting with macromolecules increases after death.</div>
</front>
</TEI>
</record>

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Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver.

Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki