Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver
Identifieur interne : 002C25 ( Main/Merge ); précédent : 002C24; suivant : 002C26Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver
Auteurs : Viswanathan Seshan [États-Unis] ; A. Dean Sherry [États-Unis] ; Navin Bansal [États-Unis]Source :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 1997-11.
English descriptors
- KwdEn :
- Bansal, Biexponential relaxation, Binding sites, Biological cations, Biological tissue, Blood cells, Blood flow, Bottom panel, Data point, Dysprosium shift reagents, Error bars, Evolution time, Extracellular, Fourier transformation, Global ischemia, Infusion, Intra, Intracellular, Intracellular sodium, Ischemia, Large percent increase, Line shape, Liver signal, Macromolecule, Magn, Malloy, Mary nell, Medical center, Methylene phosphonate, Multiple quantum, Naif, Naif signal, Nait signal, Nait signal intensity, Navin bansal, Normal saline, Peak areas, Perfused, Perfused liver, Postmortem, Preparation delay, Preparation time, Rabbit kidney, Reagent, Reference bulb, Relative change, Relative changes, Relative increase, Relaxation, Relaxation times, Reson, Resonance center, Resonance frequency, Respiratory motion, Right panel, Selective detection, Seshan, Shift reagent, Shift reagents, Signal intensities, Signal intensity, Significant change, Similar increases, Surface coil, Tqfiltered, Transverse relaxation time, Transverse relaxation times, Triple quantum, True signal, Vivo.
- Teeft :
- Bansal, Biexponential relaxation, Binding sites, Biological cations, Biological tissue, Blood cells, Blood flow, Bottom panel, Data point, Dysprosium shift reagents, Error bars, Evolution time, Extracellular, Fourier transformation, Global ischemia, Infusion, Intra, Intracellular, Intracellular sodium, Ischemia, Large percent increase, Line shape, Liver signal, Macromolecule, Magn, Malloy, Mary nell, Medical center, Methylene phosphonate, Multiple quantum, Naif, Naif signal, Nait signal, Nait signal intensity, Navin bansal, Normal saline, Peak areas, Perfused, Perfused liver, Postmortem, Preparation delay, Preparation time, Rabbit kidney, Reagent, Reference bulb, Relative change, Relative changes, Relative increase, Relaxation, Relaxation times, Reson, Resonance center, Resonance frequency, Respiratory motion, Right panel, Selective detection, Seshan, Shift reagent, Shift reagents, Signal intensities, Signal intensity, Significant change, Similar increases, Surface coil, Tqfiltered, Transverse relaxation time, Transverse relaxation times, Triple quantum, True signal, Vivo.
Abstract
Triple quantum (TQ)‐filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver, in situ. Nae+ contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+ increased by 90%. The constancy of the TQ‐filtered Nae+ signal indicates that changes in total TQ‐filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+ signal intensity. The large percent increase in the TQ‐filtered Nai+ signal as compared to the SQ signal suggests that the fraction of Nai+ interacting with macromolecules increases after death.
Url:
DOI: 10.1002/mrm.1910380519
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ISTEX:67DCD96E784E4C9F639D9236FA6D3EEBC142EA43Le document en format XML
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<term>Biexponential relaxation</term>
<term>Binding sites</term>
<term>Biological cations</term>
<term>Biological tissue</term>
<term>Blood cells</term>
<term>Blood flow</term>
<term>Bottom panel</term>
<term>Data point</term>
<term>Dysprosium shift reagents</term>
<term>Error bars</term>
<term>Evolution time</term>
<term>Extracellular</term>
<term>Fourier transformation</term>
<term>Global ischemia</term>
<term>Infusion</term>
<term>Intra</term>
<term>Intracellular</term>
<term>Intracellular sodium</term>
<term>Ischemia</term>
<term>Large percent increase</term>
<term>Line shape</term>
<term>Liver signal</term>
<term>Macromolecule</term>
<term>Magn</term>
<term>Malloy</term>
<term>Mary nell</term>
<term>Medical center</term>
<term>Methylene phosphonate</term>
<term>Multiple quantum</term>
<term>Naif</term>
<term>Naif signal</term>
<term>Nait signal</term>
<term>Nait signal intensity</term>
<term>Navin bansal</term>
<term>Normal saline</term>
<term>Peak areas</term>
<term>Perfused</term>
<term>Perfused liver</term>
<term>Postmortem</term>
<term>Preparation delay</term>
<term>Preparation time</term>
<term>Rabbit kidney</term>
<term>Reagent</term>
<term>Reference bulb</term>
<term>Relative change</term>
<term>Relative changes</term>
<term>Relative increase</term>
<term>Relaxation</term>
<term>Relaxation times</term>
<term>Reson</term>
<term>Resonance center</term>
<term>Resonance frequency</term>
<term>Respiratory motion</term>
<term>Right panel</term>
<term>Selective detection</term>
<term>Seshan</term>
<term>Shift reagent</term>
<term>Shift reagents</term>
<term>Signal intensities</term>
<term>Signal intensity</term>
<term>Significant change</term>
<term>Similar increases</term>
<term>Surface coil</term>
<term>Tqfiltered</term>
<term>Transverse relaxation time</term>
<term>Transverse relaxation times</term>
<term>Triple quantum</term>
<term>True signal</term>
<term>Vivo</term>
</keywords>
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<term>Biexponential relaxation</term>
<term>Binding sites</term>
<term>Biological cations</term>
<term>Biological tissue</term>
<term>Blood cells</term>
<term>Blood flow</term>
<term>Bottom panel</term>
<term>Data point</term>
<term>Dysprosium shift reagents</term>
<term>Error bars</term>
<term>Evolution time</term>
<term>Extracellular</term>
<term>Fourier transformation</term>
<term>Global ischemia</term>
<term>Infusion</term>
<term>Intra</term>
<term>Intracellular</term>
<term>Intracellular sodium</term>
<term>Ischemia</term>
<term>Large percent increase</term>
<term>Line shape</term>
<term>Liver signal</term>
<term>Macromolecule</term>
<term>Magn</term>
<term>Malloy</term>
<term>Mary nell</term>
<term>Medical center</term>
<term>Methylene phosphonate</term>
<term>Multiple quantum</term>
<term>Naif</term>
<term>Naif signal</term>
<term>Nait signal</term>
<term>Nait signal intensity</term>
<term>Navin bansal</term>
<term>Normal saline</term>
<term>Peak areas</term>
<term>Perfused</term>
<term>Perfused liver</term>
<term>Postmortem</term>
<term>Preparation delay</term>
<term>Preparation time</term>
<term>Rabbit kidney</term>
<term>Reagent</term>
<term>Reference bulb</term>
<term>Relative change</term>
<term>Relative changes</term>
<term>Relative increase</term>
<term>Relaxation</term>
<term>Relaxation times</term>
<term>Reson</term>
<term>Resonance center</term>
<term>Resonance frequency</term>
<term>Respiratory motion</term>
<term>Right panel</term>
<term>Selective detection</term>
<term>Seshan</term>
<term>Shift reagent</term>
<term>Shift reagents</term>
<term>Signal intensities</term>
<term>Signal intensity</term>
<term>Significant change</term>
<term>Similar increases</term>
<term>Surface coil</term>
<term>Tqfiltered</term>
<term>Transverse relaxation time</term>
<term>Transverse relaxation times</term>
<term>Triple quantum</term>
<term>True signal</term>
<term>Vivo</term>
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<front><div type="abstract" xml:lang="en">Triple quantum (TQ)‐filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver, in situ. Nae+ contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+ increased by 90%. The constancy of the TQ‐filtered Nae+ signal indicates that changes in total TQ‐filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+ signal intensity. The large percent increase in the TQ‐filtered Nai+ signal as compared to the SQ signal suggests that the fraction of Nai+ interacting with macromolecules increases after death.</div>
</front>
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