Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver
Identifieur interne : 001705 ( Istex/Corpus ); précédent : 001704; suivant : 001706Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver
Auteurs : Viswanathan Seshan ; A. Dean Sherry ; Navin BansalSource :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 1997-11.
English descriptors
- KwdEn :
- Bansal, Biexponential relaxation, Binding sites, Biological cations, Biological tissue, Blood cells, Blood flow, Bottom panel, Data point, Dysprosium shift reagents, Error bars, Evolution time, Extracellular, Fourier transformation, Global ischemia, Infusion, Intra, Intracellular, Intracellular sodium, Ischemia, Large percent increase, Line shape, Liver signal, Macromolecule, Magn, Malloy, Mary nell, Medical center, Methylene phosphonate, Multiple quantum, Naif, Naif signal, Nait signal, Nait signal intensity, Navin bansal, Normal saline, Peak areas, Perfused, Perfused liver, Postmortem, Preparation delay, Preparation time, Rabbit kidney, Reagent, Reference bulb, Relative change, Relative changes, Relative increase, Relaxation, Relaxation times, Reson, Resonance center, Resonance frequency, Respiratory motion, Right panel, Selective detection, Seshan, Shift reagent, Shift reagents, Signal intensities, Signal intensity, Significant change, Similar increases, Surface coil, Tqfiltered, Transverse relaxation time, Transverse relaxation times, Triple quantum, True signal, Vivo.
- Teeft :
- Bansal, Biexponential relaxation, Binding sites, Biological cations, Biological tissue, Blood cells, Blood flow, Bottom panel, Data point, Dysprosium shift reagents, Error bars, Evolution time, Extracellular, Fourier transformation, Global ischemia, Infusion, Intra, Intracellular, Intracellular sodium, Ischemia, Large percent increase, Line shape, Liver signal, Macromolecule, Magn, Malloy, Mary nell, Medical center, Methylene phosphonate, Multiple quantum, Naif, Naif signal, Nait signal, Nait signal intensity, Navin bansal, Normal saline, Peak areas, Perfused, Perfused liver, Postmortem, Preparation delay, Preparation time, Rabbit kidney, Reagent, Reference bulb, Relative change, Relative changes, Relative increase, Relaxation, Relaxation times, Reson, Resonance center, Resonance frequency, Respiratory motion, Right panel, Selective detection, Seshan, Shift reagent, Shift reagents, Signal intensities, Signal intensity, Significant change, Similar increases, Surface coil, Tqfiltered, Transverse relaxation time, Transverse relaxation times, Triple quantum, True signal, Vivo.
Abstract
Triple quantum (TQ)‐filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver, in situ. Nae+ contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+ increased by 90%. The constancy of the TQ‐filtered Nae+ signal indicates that changes in total TQ‐filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+ signal intensity. The large percent increase in the TQ‐filtered Nai+ signal as compared to the SQ signal suggests that the fraction of Nai+ interacting with macromolecules increases after death.
Url:
DOI: 10.1002/mrm.1910380519
Links to Exploration step
ISTEX:67DCD96E784E4C9F639D9236FA6D3EEBC142EA43Le document en format XML
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scheme="KwdEn" xml:lang="en"><term>Bansal</term><term>Biexponential relaxation</term><term>Binding sites</term><term>Biological cations</term><term>Biological tissue</term><term>Blood cells</term><term>Blood flow</term><term>Bottom panel</term><term>Data point</term><term>Dysprosium shift reagents</term><term>Error bars</term><term>Evolution time</term><term>Extracellular</term><term>Fourier transformation</term><term>Global ischemia</term><term>Infusion</term><term>Intra</term><term>Intracellular</term><term>Intracellular sodium</term><term>Ischemia</term><term>Large percent increase</term><term>Line shape</term><term>Liver signal</term><term>Macromolecule</term><term>Magn</term><term>Malloy</term><term>Mary nell</term><term>Medical center</term><term>Methylene phosphonate</term><term>Multiple quantum</term><term>Naif</term><term>Naif signal</term><term>Nait signal</term><term>Nait signal intensity</term><term>Navin bansal</term><term>Normal saline</term><term>Peak areas</term><term>Perfused</term><term>Perfused liver</term><term>Postmortem</term><term>Preparation delay</term><term>Preparation time</term><term>Rabbit kidney</term><term>Reagent</term><term>Reference bulb</term><term>Relative change</term><term>Relative changes</term><term>Relative increase</term><term>Relaxation</term><term>Relaxation times</term><term>Reson</term><term>Resonance center</term><term>Resonance frequency</term><term>Respiratory motion</term><term>Right panel</term><term>Selective detection</term><term>Seshan</term><term>Shift reagent</term><term>Shift reagents</term><term>Signal intensities</term><term>Signal intensity</term><term>Significant change</term><term>Similar increases</term><term>Surface coil</term><term>Tqfiltered</term><term>Transverse relaxation time</term><term>Transverse relaxation times</term><term>Triple quantum</term><term>True signal</term><term>Vivo</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Bansal</term><term>Biexponential relaxation</term><term>Binding sites</term><term>Biological cations</term><term>Biological tissue</term><term>Blood cells</term><term>Blood flow</term><term>Bottom panel</term><term>Data point</term><term>Dysprosium shift reagents</term><term>Error bars</term><term>Evolution time</term><term>Extracellular</term><term>Fourier transformation</term><term>Global ischemia</term><term>Infusion</term><term>Intra</term><term>Intracellular</term><term>Intracellular sodium</term><term>Ischemia</term><term>Large percent increase</term><term>Line shape</term><term>Liver signal</term><term>Macromolecule</term><term>Magn</term><term>Malloy</term><term>Mary nell</term><term>Medical center</term><term>Methylene phosphonate</term><term>Multiple quantum</term><term>Naif</term><term>Naif signal</term><term>Nait signal</term><term>Nait signal intensity</term><term>Navin bansal</term><term>Normal saline</term><term>Peak areas</term><term>Perfused</term><term>Perfused liver</term><term>Postmortem</term><term>Preparation delay</term><term>Preparation time</term><term>Rabbit kidney</term><term>Reagent</term><term>Reference bulb</term><term>Relative change</term><term>Relative changes</term><term>Relative increase</term><term>Relaxation</term><term>Relaxation times</term><term>Reson</term><term>Resonance center</term><term>Resonance frequency</term><term>Respiratory motion</term><term>Right panel</term><term>Selective detection</term><term>Seshan</term><term>Shift reagent</term><term>Shift reagents</term><term>Signal intensities</term><term>Signal intensity</term><term>Significant change</term><term>Similar increases</term><term>Surface coil</term><term>Tqfiltered</term><term>Transverse relaxation time</term><term>Transverse relaxation times</term><term>Triple quantum</term><term>True signal</term><term>Vivo</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Triple quantum (TQ)‐filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver, in situ. Nae+ contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+ increased by 90%. The constancy of the TQ‐filtered Nae+ signal indicates that changes in total TQ‐filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+ signal intensity. The large percent increase in the TQ‐filtered Nai+ signal as compared to the SQ signal suggests that the fraction of Nai+ interacting with macromolecules increases after death.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>reson</json:string><json:string>magn</json:string><json:string>naif</json:string><json:string>perfused</json:string><json:string>extracellular</json:string><json:string>ischemia</json:string><json:string>intracellular</json:string><json:string>malloy</json:string><json:string>tqfiltered</json:string><json:string>seshan</json:string><json:string>bansal</json:string><json:string>signal intensity</json:string><json:string>postmortem</json:string><json:string>macromolecule</json:string><json:string>evolution time</json:string><json:string>infusion</json:string><json:string>reagent</json:string><json:string>data point</json:string><json:string>intracellular sodium</json:string><json:string>surface coil</json:string><json:string>shift reagent</json:string><json:string>reference bulb</json:string><json:string>relaxation times</json:string><json:string>intra</json:string><json:string>relative changes</json:string><json:string>normal saline</json:string><json:string>global ischemia</json:string><json:string>triple quantum</json:string><json:string>naif signal</json:string><json:string>preparation time</json:string><json:string>peak areas</json:string><json:string>dysprosium shift reagents</json:string><json:string>biexponential relaxation</json:string><json:string>selective detection</json:string><json:string>transverse relaxation time</json:string><json:string>biological cations</json:string><json:string>preparation delay</json:string><json:string>blood cells</json:string><json:string>nait signal</json:string><json:string>large percent increase</json:string><json:string>transverse relaxation times</json:string><json:string>line shape</json:string><json:string>significant change</json:string><json:string>multiple quantum</json:string><json:string>nait signal intensity</json:string><json:string>bottom panel</json:string><json:string>right panel</json:string><json:string>biological tissue</json:string><json:string>liver signal</json:string><json:string>mary nell</json:string><json:string>respiratory motion</json:string><json:string>blood flow</json:string><json:string>relative change</json:string><json:string>resonance center</json:string><json:string>signal intensities</json:string><json:string>error bars</json:string><json:string>relative increase</json:string><json:string>similar increases</json:string><json:string>medical center</json:string><json:string>navin bansal</json:string><json:string>perfused liver</json:string><json:string>methylene phosphonate</json:string><json:string>binding sites</json:string><json:string>rabbit kidney</json:string><json:string>resonance frequency</json:string><json:string>fourier transformation</json:string><json:string>shift reagents</json:string><json:string>true signal</json:string><json:string>vivo</json:string><json:string>relaxation</json:string></teeft></keywords><author><json:item><name>Viswanathan Seshan</name><affiliations><json:string>Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas</json:string></affiliations></json:item><json:item><name>A. Dean Sherry</name><affiliations><json:string>Department of Chemistry, University of Texas at Dallas, Richardson, Texas</json:string></affiliations></json:item><json:item><name>Navin Bansal Ph.D.</name><affiliations><json:string>Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas</json:string><json:string>Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas</json:string><json:string>The Mary Nell and Ralph 8. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Rd., Dallas, TX 75235‐9085===</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>23Na MRS liver</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>shift reagent</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple quantum NMR</value></json:item></subject><articleId><json:string>MRM1910380519</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>miscellaneous</json:string></originalGenre><abstract>Triple quantum (TQ)‐filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver, in situ. Nae+ contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+ increased by 90%. The constancy of the TQ‐filtered Nae+ signal indicates that changes in total TQ‐filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+ signal intensity. The large percent increase in the TQ‐filtered Nai+ signal as compared to the SQ signal suggests that the fraction of Nai+ interacting with macromolecules increases after death.</abstract><qualityIndicators><score>6.656</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 774 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>910</abstractCharCount><pdfWordCount>5383</pdfWordCount><pdfCharCount>30484</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>138</abstractWordCount></qualityIndicators><title>Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver</title><genre><json:string>other</json:string></genre><host><title>Magnetic Resonance in Medicine</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1522-2594</json:string></doi><issn><json:string>0740-3194</json:string></issn><eissn><json:string>1522-2594</json:string></eissn><publisherId><json:string>MRM</json:string></publisherId><volume>38</volume><issue>5</issue><pages><first>821</first><last>827</last><total>7</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Notes</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>radiology, nuclear medicine & medical imaging</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>nuclear medicine & medical imaging</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>vertebres: systeme urinaire</json:string></inist></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1002/mrm.1910380519</json:string></doi><id>67DCD96E784E4C9F639D9236FA6D3EEBC142EA43</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/67DCD96E784E4C9F639D9236FA6D3EEBC142EA43/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/67DCD96E784E4C9F639D9236FA6D3EEBC142EA43/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/67DCD96E784E4C9F639D9236FA6D3EEBC142EA43/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Evaluation of triple quantum‐filtered <hi rend="superscript">23</hi>Na NMR spectroscopy in the <hi rend="italic">in situ</hi> rat liver</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Baltimore</pubPlace><availability><licence>Copyright © 1997 Wiley‐Liss, Inc., A Wiley Company</licence></availability><date type="published" when="1997-11"></date></publicationStmt><notesStmt><note type="content-type" subtype="other" source="miscellaneous" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-7474895G-0">other</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="other"><analytic><title level="a" type="main" xml:lang="en">Evaluation of triple quantum‐filtered <hi rend="superscript">23</hi>Na NMR spectroscopy in the <hi rend="italic">in situ</hi> rat liver</title><title level="a" type="short" xml:lang="en">TQ‐Filtered 23Na NMR of the Rat Liver in Situ</title><author xml:id="author-0000"><persName><forename type="first">Viswanathan</forename><surname>Seshan</surname></persName><affiliation>Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas<address><country key="US"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">A. Dean</forename><surname>Sherry</surname></persName><affiliation>Department of Chemistry, University of Texas at Dallas, Richardson, Texas<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002" role="corresp"><persName><forename type="first">Navin</forename><surname>Bansal</surname><roleName type="degree">Ph.D.</roleName></persName><affiliation>Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas<address><country key="US"></country></address></affiliation><affiliation>Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas<address><country key="US"></country></address></affiliation><affiliation>The Mary Nell and Ralph 8. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Rd., Dallas, TX 75235‐9085===</affiliation></author><idno type="istex">67DCD96E784E4C9F639D9236FA6D3EEBC142EA43</idno><idno type="ark">ark:/67375/WNG-6FD66G96-9</idno><idno type="DOI">10.1002/mrm.1910380519</idno><idno type="unit">MRM1910380519</idno><idno type="toTypesetVersion">file:MRM.MRM1910380519.pdf</idno></analytic><monogr><title level="j" type="main">Magnetic Resonance in Medicine</title><title level="j" type="alt">MAGNETIC RESONANCE IN MEDICINE</title><idno type="pISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><idno type="book-DOI">10.1002/(ISSN)1522-2594</idno><idno type="book-part-DOI">10.1002/mrm.v38:5</idno><idno type="product">MRM</idno><imprint><biblScope unit="vol">38</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="821">821</biblScope><biblScope unit="page" to="827">827</biblScope><biblScope unit="page-count">7</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Baltimore</pubPlace><date type="published" when="1997-11"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Triple quantum (TQ)‐filtered <hi rend="superscript">23</hi>Na NMR spectroscopy and the shift reagent, TmDOTP<hi rend="superscript">5‐</hi>, have been used to evaluate the contributions of intra‐ (Na<hi rend="subscript">i</hi><hi rend="superscript">+</hi>) and extracellular (Na<hi rend="subscript">e</hi><hi rend="superscript">+</hi>) sodium to the TQ‐filtered signal in the rat liver, <hi rend="italic">in situ.</hi> Na<hi rend="subscript">e</hi><hi rend="superscript">+</hi> contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Na<hi rend="subscript">i</hi><hi rend="superscript">+</hi> signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Na<hi rend="subscript">i</hi><hi rend="superscript">+</hi> increased by 90%. The constancy of the TQ‐filtered Na<hi rend="subscript">e</hi><hi rend="superscript">+</hi> signal indicates that changes in total TQ‐filtered <hi rend="superscript">23</hi>Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Na<hi rend="subscript">i</hi><hi rend="superscript">+</hi> signal intensity. The large percent increase in the TQ‐filtered Na<hi rend="subscript">i</hi><hi rend="superscript">+</hi> signal as compared to the SQ signal suggests that the fraction of Na<hi rend="subscript">i</hi><hi rend="superscript">+</hi> interacting with macromolecules increases after death.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1"><hi rend="superscript">23</hi>Na MRS liver</term><term xml:id="kwd2">shift reagent</term><term xml:id="kwd3">multiple quantum NMR</term></keywords><keywords rend="articleCategory"><term>Notes</term></keywords><keywords rend="tocHeading1"><term>Notess</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/67DCD96E784E4C9F639D9236FA6D3EEBC142EA43/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Baltimore</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1522-2594</doi><issn type="print">0740-3194</issn><issn type="electronic">1522-2594</issn><idGroup><id type="product" value="MRM"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MAGNETIC RESONANCE IN MEDICINE">Magnetic Resonance in Medicine</title><title type="short">Magn. Reson. Med.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/mrm.v38:5</doi><numberingGroup><numbering type="journalVolume" number="38">38</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="1997-11">November 1997</coverDate></publicationMeta><publicationMeta level="unit" type="miscellaneous" position="19" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mrm.1910380519</doi><idGroup><id type="unit" value="MRM1910380519"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Notes</title><title type="tocHeading1">Notess</title></titleGroup><copyright ownership="publisher">Copyright © 1997 Wiley‐Liss, Inc., A Wiley Company</copyright><eventGroup><event type="manuscriptReceived" date="1996-03-19"></event><event type="manuscriptRevised" date="1997-04-18"></event><event type="manuscriptAccepted" date="1997-04-21"></event><event type="firstOnline" date="2005-12-12"></event><event type="publishedOnlineFinalForm" date="2005-12-12"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">821</numbering><numbering type="pageLast">827</numbering></numberingGroup><correspondenceTo>The Mary Nell and Ralph 8. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Rd., Dallas, TX 75235‐9085===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MRM.MRM1910380519.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="6"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="34"></count></countGroup><titleGroup><title type="main" xml:lang="en">Evaluation of triple quantum‐filtered <sup>23</sup>Na NMR spectroscopy in the <i>in situ</i> rat liver</title><title type="short" xml:lang="en">TQ‐Filtered <sup>23</sup>Na NMR of the Rat Liver in Situ</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Viswanathan</givenNames><familyName>Seshan</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>A. Dean</givenNames><familyName>Sherry</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Navin</givenNames><familyName>Bansal</familyName><degrees>Ph.D.</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Chemistry, University of Texas at Dallas, Richardson, Texas</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1"><sup>23</sup>Na MRS liver</keyword><keyword xml:id="kwd2">shift reagent</keyword><keyword xml:id="kwd3">multiple quantum NMR</keyword></keywordGroup><fundingInfo><fundingAgency>Whitaker Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>American Heart Association</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Robert A. Welch Foundation</fundingAgency><fundingNumber>AT‐584</fundingNumber><fundingNumber>HL‐54574</fundingNumber><fundingNumber>RR‐02584</fundingNumber></fundingInfo><fundingInfo><fundingAgency>National Institutes of Health</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Triple quantum (TQ)‐filtered <sup>23</sup>Na NMR spectroscopy and the shift reagent, TmDOTP<sup>5‐</sup>, have been used to evaluate the contributions of intra‐ (Na<sub>i</sub><sup>+</sup>) and extracellular (Na<sub>e</sub><sup>+</sup>) sodium to the TQ‐filtered signal in the rat liver, <i>in situ.</i> Na<sub>e</sub><sup>+</sup> contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Na<sub>i</sub><sup>+</sup> signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Na<sub>i</sub><sup>+</sup> increased by 90%. The constancy of the TQ‐filtered Na<sub>e</sub><sup>+</sup> signal indicates that changes in total TQ‐filtered <sup>23</sup>Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Na<sub>i</sub><sup>+</sup> signal intensity. The large percent increase in the TQ‐filtered Na<sub>i</sub><sup>+</sup> signal as compared to the SQ signal suggests that the fraction of Na<sub>i</sub><sup>+</sup> interacting with macromolecules increases after death.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>TQ‐Filtered 23Na NMR of the Rat Liver in Situ</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Evaluation of triple quantum‐filtered 23Na NMR spectroscopy in the in situ rat liver</title></titleInfo><name type="personal"><namePart type="given">Viswanathan</namePart><namePart type="family">Seshan</namePart><affiliation>Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. Dean</namePart><namePart type="family">Sherry</namePart><affiliation>Department of Chemistry, University of Texas at Dallas, Richardson, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Navin</namePart><namePart type="family">Bansal</namePart><namePart type="termsOfAddress">Ph.D.</namePart><affiliation>Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas</affiliation><affiliation>Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas</affiliation><affiliation>Correspondence address: The Mary Nell and Ralph 8. Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Rd., Dallas, TX 75235‐9085===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="miscellaneous" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Baltimore</placeTerm></place><dateIssued encoding="w3cdtf">1997-11</dateIssued><dateCaptured encoding="w3cdtf">1996-03-19</dateCaptured><dateValid encoding="w3cdtf">1997-04-21</dateValid><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="tables">0</extent><extent unit="references">34</extent></physicalDescription><abstract lang="en">Triple quantum (TQ)‐filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver, in situ. Nae+ contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+ increased by 90%. The constancy of the TQ‐filtered Nae+ signal indicates that changes in total TQ‐filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+ signal intensity. The large percent increase in the TQ‐filtered Nai+ signal as compared to the SQ signal suggests that the fraction of Nai+ interacting with macromolecules increases after death.</abstract><note type="funding">Whitaker Foundation</note><note type="funding">American Heart Association</note><note type="funding">Robert A. Welch Foundation - No. AT‐584; No. HL‐54574; No. RR‐02584; </note><note type="funding">National Institutes of Health</note><subject lang="en"><genre>keywords</genre><topic>23Na MRS liver</topic><topic>shift reagent</topic><topic>multiple quantum NMR</topic></subject><relatedItem type="host"><titleInfo><title>Magnetic Resonance in Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Magn. Reson. Med.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Notes</topic></subject><identifier type="ISSN">0740-3194</identifier><identifier type="eISSN">1522-2594</identifier><identifier type="DOI">10.1002/(ISSN)1522-2594</identifier><identifier type="PublisherID">MRM</identifier><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>821</start><end>827</end><total>7</total></extent></part></relatedItem><identifier type="istex">67DCD96E784E4C9F639D9236FA6D3EEBC142EA43</identifier><identifier type="ark">ark:/67375/WNG-6FD66G96-9</identifier><identifier type="DOI">10.1002/mrm.1910380519</identifier><identifier type="ArticleID">MRM1910380519</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1997 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/67DCD96E784E4C9F639D9236FA6D3EEBC142EA43/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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