In vivo detection of PARACEST agents with relaxation correction
Identifieur interne : 000D26 ( Main/Exploration ); précédent : 000D25; suivant : 000D27In vivo detection of PARACEST agents with relaxation correction
Auteurs : Craig K. Jones [Canada] ; Alex X. Li [Canada] ; Mojmír Such [Canada] ; Robert H. E. Hudson [Canada] ; Ravi S. Menon [Canada] ; Robert Bartha [Canada]Source :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 2010-05.
Descripteurs français
- Wicri :
- topic : Taux de change.
English descriptors
- KwdEn :
- Agent concentration, Agent injection, Analytical solution, Baseline, Baseline value, Bloch equations, Bovine serum albumin, Bulk water, Bulk water protons, Bulk water relaxation, Bulk water visibility, Chemical shift, Contrast agent, Contrast agent injection, Contrast agents, Control images, Current study, Detection sensitivity, Echo time, Exchange rate, Exchange terms, Exchangeable proton, Exchangeable protons, Exponential, Exponential relation, Flash images, Flash pulse sequence, Flash sequence, Flash signal equation, Flip angle, Good agreement, Gradient echo pulse sequence, Image signal intensity, Imaging, Initial value, Kidney, Magn, Magn reson, Medulla, Medulla region, Metabolic mapping, Mouse kidney, Oparachee, Oparachee contrast, Oparachee curve, Oparachee effect, Oparachee mechanism, Oparachee percentage change, Oparachee signal, Paracest, Paracest agent, Paracest agents, Paracest effect, Paramagnetic chemical exchange effects, Paramagnetic chemical exchange saturation transfer, Phantom, Phantom relaxation measurements, Physiologic parameters, Preparation pulse, Previous studies, Proton, Proton chemical exchange, Pulse, Pulse sequence, Pulse sequences, Relaxation, Relaxation effects, Relaxation mechanisms, Relaxation parameters, Relaxation time, Relaxation time constants, Reson, Robarts research institute, Robert bartha, Second acquisition, Second image, Siflash, Signal change, Signal changes, Signal equation, Signal intensities, Signal variation, Simodeled, Simodeled flash, Slow exchange condition, Such sequences, Superior edge, Time constants, Time course, Time courses, Time point, Vivo, Vivo agent concentration, Vivo detection, Vivo paracest, Waltz preparation, Western ontario, Zhang.
- Teeft :
- Agent concentration, Agent injection, Analytical solution, Baseline, Baseline value, Bloch equations, Bovine serum albumin, Bulk water, Bulk water protons, Bulk water relaxation, Bulk water visibility, Chemical shift, Contrast agent, Contrast agent injection, Contrast agents, Control images, Current study, Detection sensitivity, Echo time, Exchange rate, Exchange terms, Exchangeable proton, Exchangeable protons, Exponential, Exponential relation, Flash images, Flash pulse sequence, Flash sequence, Flash signal equation, Flip angle, Good agreement, Gradient echo pulse sequence, Image signal intensity, Imaging, Initial value, Kidney, Magn, Magn reson, Medulla, Medulla region, Metabolic mapping, Mouse kidney, Oparachee, Oparachee contrast, Oparachee curve, Oparachee effect, Oparachee mechanism, Oparachee percentage change, Oparachee signal, Paracest, Paracest agent, Paracest agents, Paracest effect, Paramagnetic chemical exchange effects, Paramagnetic chemical exchange saturation transfer, Phantom, Phantom relaxation measurements, Physiologic parameters, Preparation pulse, Previous studies, Proton, Proton chemical exchange, Pulse, Pulse sequence, Pulse sequences, Relaxation, Relaxation effects, Relaxation mechanisms, Relaxation parameters, Relaxation time, Relaxation time constants, Reson, Robarts research institute, Robert bartha, Second acquisition, Second image, Siflash, Signal change, Signal changes, Signal equation, Signal intensities, Signal variation, Simodeled, Simodeled flash, Slow exchange condition, Such sequences, Superior edge, Time constants, Time course, Time courses, Time point, Vivo, Vivo agent concentration, Vivo detection, Vivo paracest, Waltz preparation, Western ontario, Zhang.
Abstract
Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the uptake over time following a bolus injection. The observed signal change is a combination of relaxation effects and PARACEST contrast. The purpose of the current study was to isolate the PARACEST effect from the changes in bulk water relaxation induced by the PARACEST agent in vivo for the fast low‐angle shot pulse sequence. A fast low‐angle shot–based pulse sequence was used to acquire continuous images on a 9.4‐T MRI of phantoms and the kidneys of mice following PARACEST agent (Tm3+‐DOTAM‐Gly‐Lys) injection. A WALTZ‐16 pulse was applied before every second image to generate on‐resonance paramagnetic chemical exchange effects. Signal intensity changes of up to 50% were observed in the mouse kidney in the control images (without a WALTZ‐16 preparation pulse) due to altered bulk water relaxation induced by the PARACEST agent. Despite these changes, a clear on‐resonance paramagnetic chemical exchange effect of 4‐7% was also observed. A four‐pool exchange model was used to describe image signal intensity. This study demonstrates that in vivo on‐resonance paramagnetic chemical exchange effect contrast can be isolated from tissue relaxation time constant changes induced by a PARACEST agent that dominate the signal change. Magn Reson Med 63:1184–1192, 2010. © 2010 Wiley‐Liss, Inc.
Url:
- https://api.istex.fr/document/1611F0A9928A6FBBC9E36091C8089CA084DE4134/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427884
DOI: 10.1002/mrm.22340
Affiliations:
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Jones</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X." last="Li">Alex X. Li</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Such, Mojmir" sort="Such, Mojmir" uniqKey="Such M" first="Mojmír" last="Such">Mojmír Such</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H. E." last="Hudson">Robert H. E. Hudson</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. Menon</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, The University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Correspondence address: Centre for Functional and Metabolic Mapping, Robarts Research Institute, 100 Perth Drive, PO Box 5015, London, ON N6A 5K8</wicri:regionArea><wicri:noRegion>ON N6A 5K8</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Magnetic Resonance in Medicine</title><title level="j" type="alt">MAGNETIC RESONANCE IN MEDICINE</title><idno type="ISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><imprint><biblScope unit="vol">63</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1184">1184</biblScope><biblScope unit="page" to="1192">1192</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-05">2010-05</date></imprint><idno type="ISSN">0740-3194</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0740-3194</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agent concentration</term><term>Agent injection</term><term>Analytical solution</term><term>Baseline</term><term>Baseline value</term><term>Bloch equations</term><term>Bovine serum albumin</term><term>Bulk water</term><term>Bulk water protons</term><term>Bulk water relaxation</term><term>Bulk water visibility</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agent injection</term><term>Contrast agents</term><term>Control images</term><term>Current study</term><term>Detection sensitivity</term><term>Echo time</term><term>Exchange rate</term><term>Exchange terms</term><term>Exchangeable proton</term><term>Exchangeable protons</term><term>Exponential</term><term>Exponential relation</term><term>Flash images</term><term>Flash pulse sequence</term><term>Flash sequence</term><term>Flash signal equation</term><term>Flip angle</term><term>Good agreement</term><term>Gradient echo pulse sequence</term><term>Image signal intensity</term><term>Imaging</term><term>Initial value</term><term>Kidney</term><term>Magn</term><term>Magn reson</term><term>Medulla</term><term>Medulla region</term><term>Metabolic mapping</term><term>Mouse kidney</term><term>Oparachee</term><term>Oparachee contrast</term><term>Oparachee curve</term><term>Oparachee effect</term><term>Oparachee mechanism</term><term>Oparachee percentage change</term><term>Oparachee signal</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Paracest effect</term><term>Paramagnetic chemical exchange effects</term><term>Paramagnetic chemical exchange saturation transfer</term><term>Phantom</term><term>Phantom relaxation measurements</term><term>Physiologic parameters</term><term>Preparation pulse</term><term>Previous studies</term><term>Proton</term><term>Proton chemical exchange</term><term>Pulse</term><term>Pulse sequence</term><term>Pulse sequences</term><term>Relaxation</term><term>Relaxation effects</term><term>Relaxation mechanisms</term><term>Relaxation parameters</term><term>Relaxation time</term><term>Relaxation time constants</term><term>Reson</term><term>Robarts research institute</term><term>Robert bartha</term><term>Second acquisition</term><term>Second image</term><term>Siflash</term><term>Signal change</term><term>Signal changes</term><term>Signal equation</term><term>Signal intensities</term><term>Signal variation</term><term>Simodeled</term><term>Simodeled flash</term><term>Slow exchange condition</term><term>Such sequences</term><term>Superior edge</term><term>Time constants</term><term>Time course</term><term>Time courses</term><term>Time point</term><term>Vivo</term><term>Vivo agent concentration</term><term>Vivo detection</term><term>Vivo paracest</term><term>Waltz preparation</term><term>Western ontario</term><term>Zhang</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Agent concentration</term><term>Agent injection</term><term>Analytical solution</term><term>Baseline</term><term>Baseline value</term><term>Bloch equations</term><term>Bovine serum albumin</term><term>Bulk water</term><term>Bulk water protons</term><term>Bulk water relaxation</term><term>Bulk water visibility</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agent injection</term><term>Contrast agents</term><term>Control images</term><term>Current study</term><term>Detection sensitivity</term><term>Echo time</term><term>Exchange rate</term><term>Exchange terms</term><term>Exchangeable proton</term><term>Exchangeable protons</term><term>Exponential</term><term>Exponential relation</term><term>Flash images</term><term>Flash pulse sequence</term><term>Flash sequence</term><term>Flash signal equation</term><term>Flip angle</term><term>Good agreement</term><term>Gradient echo pulse sequence</term><term>Image signal intensity</term><term>Imaging</term><term>Initial value</term><term>Kidney</term><term>Magn</term><term>Magn reson</term><term>Medulla</term><term>Medulla region</term><term>Metabolic mapping</term><term>Mouse kidney</term><term>Oparachee</term><term>Oparachee contrast</term><term>Oparachee curve</term><term>Oparachee effect</term><term>Oparachee mechanism</term><term>Oparachee percentage change</term><term>Oparachee signal</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Paracest effect</term><term>Paramagnetic chemical exchange effects</term><term>Paramagnetic chemical exchange saturation transfer</term><term>Phantom</term><term>Phantom relaxation measurements</term><term>Physiologic parameters</term><term>Preparation pulse</term><term>Previous studies</term><term>Proton</term><term>Proton chemical exchange</term><term>Pulse</term><term>Pulse sequence</term><term>Pulse sequences</term><term>Relaxation</term><term>Relaxation effects</term><term>Relaxation mechanisms</term><term>Relaxation parameters</term><term>Relaxation time</term><term>Relaxation time constants</term><term>Reson</term><term>Robarts research institute</term><term>Robert bartha</term><term>Second acquisition</term><term>Second image</term><term>Siflash</term><term>Signal change</term><term>Signal changes</term><term>Signal equation</term><term>Signal intensities</term><term>Signal variation</term><term>Simodeled</term><term>Simodeled flash</term><term>Slow exchange condition</term><term>Such sequences</term><term>Superior edge</term><term>Time constants</term><term>Time course</term><term>Time courses</term><term>Time point</term><term>Vivo</term><term>Vivo agent concentration</term><term>Vivo detection</term><term>Vivo paracest</term><term>Waltz preparation</term><term>Western ontario</term><term>Zhang</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Taux de change</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the uptake over time following a bolus injection. The observed signal change is a combination of relaxation effects and PARACEST contrast. The purpose of the current study was to isolate the PARACEST effect from the changes in bulk water relaxation induced by the PARACEST agent in vivo for the fast low‐angle shot pulse sequence. A fast low‐angle shot–based pulse sequence was used to acquire continuous images on a 9.4‐T MRI of phantoms and the kidneys of mice following PARACEST agent (Tm3+‐DOTAM‐Gly‐Lys) injection. A WALTZ‐16 pulse was applied before every second image to generate on‐resonance paramagnetic chemical exchange effects. Signal intensity changes of up to 50% were observed in the mouse kidney in the control images (without a WALTZ‐16 preparation pulse) due to altered bulk water relaxation induced by the PARACEST agent. Despite these changes, a clear on‐resonance paramagnetic chemical exchange effect of 4‐7% was also observed. A four‐pool exchange model was used to describe image signal intensity. This study demonstrates that in vivo on‐resonance paramagnetic chemical exchange effect contrast can be isolated from tissue relaxation time constant changes induced by a PARACEST agent that dominate the signal change. Magn Reson Med 63:1184–1192, 2010. © 2010 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Jones, Craig K" sort="Jones, Craig K" uniqKey="Jones C" first="Craig K." last="Jones">Craig K. Jones</name></noRegion><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H. E." last="Hudson">Robert H. E. Hudson</name><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X." last="Li">Alex X. Li</name><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X." last="Li">Alex X. Li</name><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. Menon</name><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. Menon</name><name sortKey="Such, Mojmir" sort="Such, Mojmir" uniqKey="Such M" first="Mojmír" last="Such">Mojmír Such</name><name sortKey="Such, Mojmir" sort="Such, Mojmir" uniqKey="Such M" first="Mojmír" last="Such">Mojmír Such</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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