In Vivo Detection of PARACEST Agents With Relaxation Correction
Identifieur interne : 000380 ( Pmc/Curation ); précédent : 000379; suivant : 000381In Vivo Detection of PARACEST Agents With Relaxation Correction
Auteurs : Craig K. Jones [Canada] ; Alex X. Li [Canada] ; Mojmír Such [Canada] ; Robert H E. Hudson [Canada] ; Ravi S. Menon [Canada] ; Robert Bartha [Canada]Source :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 2010.
Abstract
Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the uptake over time following a bolus injection. The observed signal change is a combination of relaxation effects and PARACEST contrast. The purpose of the current study was to isolate the PARACEST effect from the changes in bulk water relaxation induced by the PARACEST agent in vivo for the fast low-angle shot pulse sequence. A fast low-angle shot–based pulse sequence was used to acquire continuous images on a 9.4-T MRI of phantoms and the kidneys of mice following PARACEST agent (Tm3+-DOTAM-Gly-Lys) injection. A WALTZ-16 pulse was applied before every second image to generate on-resonance paramagnetic chemical exchange effects. Signal intensity changes of up to 50% were observed in the mouse kidney in the control images (without a WALTZ-16 preparation pulse) due to altered bulk water relaxation induced by the PARACEST agent. Despite these changes, a clear on-resonance paramagnetic chemical exchange effect of 4-7% was also observed. A four-pool exchange model was used to describe image signal intensity. This study demonstrates that in vivo on-resonance paramagnetic chemical exchange effect contrast can be isolated from tissue relaxation time constant changes induced by a PARACEST agent that dominate the signal change. Magn Reson Med 63:1184–1192, 2010. © 2010 Wiley-Liss, Inc.
Url:
DOI: 10.1002/mrm.22340
PubMed: 20432289
PubMed Central: 3427884
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<front><div type="abstract" xml:lang="en"><p>Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the uptake over time following a bolus injection. The observed signal change is a combination of relaxation effects and PARACEST contrast. The purpose of the current study was to isolate the PARACEST effect from the changes in bulk water relaxation induced by the PARACEST agent in vivo for the fast low-angle shot pulse sequence. A fast low-angle shot–based pulse sequence was used to acquire continuous images on a 9.4-T MRI of phantoms and the kidneys of mice following PARACEST agent (Tm<sup>3+</sup>
-DOTAM-Gly-Lys) injection. A WALTZ-16 pulse was applied before every second image to generate on-resonance paramagnetic chemical exchange effects. Signal intensity changes of up to 50% were observed in the mouse kidney in the control images (without a WALTZ-16 preparation pulse) due to altered bulk water relaxation induced by the PARACEST agent. Despite these changes, a clear on-resonance paramagnetic chemical exchange effect of 4-7% was also observed. A four-pool exchange model was used to describe image signal intensity. This study demonstrates that in vivo on-resonance paramagnetic chemical exchange effect contrast can be isolated from tissue relaxation time constant changes induced by a PARACEST agent that dominate the signal change. Magn Reson Med 63:1184–1192, 2010. © 2010 Wiley-Liss, Inc.</p>
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<author><name sortKey="Marcos, H" uniqKey="Marcos H">H Marcos</name>
</author>
<author><name sortKey="Li, Kc" uniqKey="Li K">KC Li</name>
</author>
<author><name sortKey="Kopp, Jb" uniqKey="Kopp J">JB Kopp</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name>
</author>
<author><name sortKey="Gillen, J" uniqKey="Gillen J">J Gillen</name>
</author>
<author><name sortKey="Landman, Ba" uniqKey="Landman B">BA Landman</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Van Zijl, Pcm" uniqKey="Van Zijl P">PCM van Zijl</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Magn Reson Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Magn Reson Med</journal-id>
<journal-id journal-id-type="publisher-id">mrm</journal-id>
<journal-title-group><journal-title>Magnetic Resonance in Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">0740-3194</issn>
<issn pub-type="epub">1522-2594</issn>
<publisher><publisher-name>Wiley Subscription Services, Inc., A Wiley Company</publisher-name>
<publisher-loc>Hoboken</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20432289</article-id>
<article-id pub-id-type="pmc">3427884</article-id>
<article-id pub-id-type="doi">10.1002/mrm.22340</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Full Papers</subject>
</subj-group>
</article-categories>
<title-group><article-title>In Vivo Detection of PARACEST Agents With Relaxation Correction</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Craig K</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Alex X</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Suchý</surname>
<given-names>Mojmír</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hudson</surname>
<given-names>Robert H E</given-names>
</name>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Menon</surname>
<given-names>Ravi S</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bartha</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<aff id="au1"><label>1</label>
<institution>Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario</institution>
<addr-line>London, Ontario, Canada</addr-line>
</aff>
<aff id="au2"><label>2</label>
<institution>Department of Medical Biophysics, The University of Western Ontario</institution>
<addr-line>London, Ontario, Canada</addr-line>
</aff>
<aff id="au3"><label>3</label>
<institution>Department of Chemistry, The University of Western Ontario</institution>
<addr-line>London, Ontario, Canada</addr-line>
</aff>
</contrib-group>
<author-notes><corresp id="cor1">*Correspondence to: Robert Bartha, Ph.D., Centre for Functional and Metabolic Mapping, Robarts Research Institute, 100 Perth Drive, PO Box 5015, London, ON N6A 5K8, Canada. E-mail: <email>rbartha@imaging.robarts.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>5</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>4</month>
<year>2010</year>
</pub-date>
<volume>63</volume>
<issue>5</issue>
<fpage>1184</fpage>
<lpage>1192</lpage>
<history><date date-type="received"><day>17</day>
<month>6</month>
<year>2009</year>
</date>
<date date-type="rev-recd"><day>03</day>
<month>11</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>01</day>
<month>12</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2010 Wiley-Liss, Inc.</copyright-statement>
<copyright-year>2010</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.</license-p>
</license>
</permissions>
<abstract><p>Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the uptake over time following a bolus injection. The observed signal change is a combination of relaxation effects and PARACEST contrast. The purpose of the current study was to isolate the PARACEST effect from the changes in bulk water relaxation induced by the PARACEST agent in vivo for the fast low-angle shot pulse sequence. A fast low-angle shot–based pulse sequence was used to acquire continuous images on a 9.4-T MRI of phantoms and the kidneys of mice following PARACEST agent (Tm<sup>3+</sup>
-DOTAM-Gly-Lys) injection. A WALTZ-16 pulse was applied before every second image to generate on-resonance paramagnetic chemical exchange effects. Signal intensity changes of up to 50% were observed in the mouse kidney in the control images (without a WALTZ-16 preparation pulse) due to altered bulk water relaxation induced by the PARACEST agent. Despite these changes, a clear on-resonance paramagnetic chemical exchange effect of 4-7% was also observed. A four-pool exchange model was used to describe image signal intensity. This study demonstrates that in vivo on-resonance paramagnetic chemical exchange effect contrast can be isolated from tissue relaxation time constant changes induced by a PARACEST agent that dominate the signal change. Magn Reson Med 63:1184–1192, 2010. © 2010 Wiley-Liss, Inc.</p>
</abstract>
<kwd-group><kwd>PARACEST</kwd>
<kwd>in-vivo</kwd>
<kwd>kidney</kwd>
<kwd>OPARACHEE</kwd>
<kwd>contrast agent</kwd>
<kwd>MRI</kwd>
<kwd>chemical exchange</kwd>
<kwd>relaxation, mouse</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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