Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone
Identifieur interne : 009525 ( Main/Curation ); précédent : 009524; suivant : 009526Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone
Auteurs : Louis-Dumond Joseph ; Ibrahim M. Yousef ; Gabriel L. Plaa ; Mahmoud SharkawiSource :
- Toxicology Letters [ 0378-4274 ] ; 1992.
English descriptors
- KwdEn :
- Animals, Bile Acids and Salts (secretion), Bile Canaliculi (drug effects), Bile Canaliculi (secretion), Biological Transport (drug effects), Body Weight (drug effects), Cholestasis, Intrahepatic (chemically induced), Drug Synergism, Lithocholic Acid (toxicity), Male, Methyl n-Butyl Ketone (pharmacology), Organ Size (drug effects), Rats, Rats, Inbred Strains, Taurocholic Acid (metabolism).
- MESH :
- chemical , metabolism : Taurocholic Acid.
- chemical , pharmacology : Methyl n-Butyl Ketone.
- chemical , secretion : Bile Acids and Salts.
- chemically induced : Cholestasis, Intrahepatic.
- drug effects : Bile Canaliculi, Biological Transport, Body Weight, Organ Size.
- secretion : Bile Canaliculi.
- chemical , toxicity : Lithocholic Acid.
- Animals, Drug Synergism, Male, Rats, Rats, Inbred Strains.
Abstract
Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.
Url:
DOI: 10.1016/0378-4274(92)90061-N
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Louis-Dumond Joseph<affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation>Le document en format XML
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Plaa</name></author><author><name sortKey="Sharkawi, Mahmoud" sort="Sharkawi, Mahmoud" uniqKey="Sharkawi M" first="Mahmoud" last="Sharkawi">Mahmoud Sharkawi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0378-4274(92)90061-N</idno><idno type="url">https://api.istex.fr/document/C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004334</idno><idno type="wicri:Area/Istex/Curation">004334</idno><idno type="wicri:Area/Istex/Checkpoint">004469</idno><idno type="wicri:doubleKey">0378-4274:1992:Joseph L:potentiation:of:lithocholic</idno><idno type="wicri:Area/Main/Merge">009F41</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:1609437</idno><idno type="wicri:Area/PubMed/Corpus">002196</idno><idno type="wicri:Area/PubMed/Curation">002196</idno><idno type="wicri:Area/PubMed/Checkpoint">001F14</idno><idno type="wicri:Area/Ncbi/Merge">000784</idno><idno type="wicri:Area/Ncbi/Curation">000784</idno><idno type="wicri:Area/Ncbi/Checkpoint">000784</idno><idno type="wicri:doubleKey">0378-4274:1992:Joseph L:potentiation:of:lithocholic</idno><idno type="wicri:Area/Main/Merge">009F07</idno><idno type="wicri:Area/Main/Curation">009525</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title><author><name sortKey="Joseph, Louis Dumond" sort="Joseph, Louis Dumond" uniqKey="Joseph L" first="Louis-Dumond" last="Joseph">Louis-Dumond Joseph</name><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation></author><author><name sortKey="Yousef, Ibrahim M" sort="Yousef, Ibrahim M" uniqKey="Yousef I" first="Ibrahim M." last="Yousef">Ibrahim M. Yousef</name><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation></author><author><name sortKey="Plaa, Gabriel L" sort="Plaa, Gabriel L" uniqKey="Plaa G" first="Gabriel L." last="Plaa">Gabriel L. Plaa</name><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation></author><author><name sortKey="Sharkawi, Mahmoud" sort="Sharkawi, Mahmoud" uniqKey="Sharkawi M" first="Mahmoud" last="Sharkawi">Mahmoud Sharkawi</name><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology Letters</title><title level="j" type="abbrev">TOXLET</title><idno type="ISSN">0378-4274</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="39">39</biblScope><biblScope unit="page" to="47">47</biblScope></imprint><idno type="ISSN">0378-4274</idno></series><idno type="istex">C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</idno><idno type="DOI">10.1016/0378-4274(92)90061-N</idno><idno type="PII">0378-4274(92)90061-N</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-4274</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bile Acids and Salts (secretion)</term><term>Bile Canaliculi (drug effects)</term><term>Bile Canaliculi (secretion)</term><term>Biological Transport (drug effects)</term><term>Body Weight (drug effects)</term><term>Cholestasis, Intrahepatic (chemically induced)</term><term>Drug Synergism</term><term>Lithocholic Acid (toxicity)</term><term>Male</term><term>Methyl n-Butyl Ketone (pharmacology)</term><term>Organ Size (drug effects)</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Taurocholic Acid (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Taurocholic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Methyl n-Butyl Ketone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Bile Acids and Salts</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cholestasis, Intrahepatic</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bile Canaliculi</term><term>Biological Transport</term><term>Body Weight</term><term>Organ Size</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Bile Canaliculi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Lithocholic Acid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Synergism</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</div></front></TEI><double idat="0378-4274:1992:Joseph L:potentiation:of:lithocholic"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title><author><name sortKey="Joseph, Louis Dumond" sort="Joseph, Louis Dumond" uniqKey="Joseph L" first="Louis-Dumond" last="Joseph">Louis-Dumond Joseph</name></author><author><name sortKey="Yousef, Ibrahim M" sort="Yousef, Ibrahim M" uniqKey="Yousef I" first="Ibrahim M." last="Yousef">Ibrahim M. Yousef</name></author><author><name sortKey="Plaa, Gabriel L" sort="Plaa, Gabriel L" uniqKey="Plaa G" first="Gabriel L." last="Plaa">Gabriel L. Plaa</name></author><author><name sortKey="Sharkawi, Mahmoud" sort="Sharkawi, Mahmoud" uniqKey="Sharkawi M" first="Mahmoud" last="Sharkawi">Mahmoud Sharkawi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0378-4274(92)90061-N</idno><idno type="url">https://api.istex.fr/document/C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004334</idno><idno type="wicri:Area/Istex/Curation">004334</idno><idno type="wicri:Area/Istex/Checkpoint">004469</idno><idno type="wicri:doubleKey">0378-4274:1992:Joseph L:potentiation:of:lithocholic</idno><idno type="wicri:Area/Main/Merge">009F41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title><author><name sortKey="Joseph, Louis Dumond" sort="Joseph, Louis Dumond" uniqKey="Joseph L" first="Louis-Dumond" last="Joseph">Louis-Dumond Joseph</name><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation></author><author><name sortKey="Yousef, Ibrahim M" sort="Yousef, Ibrahim M" uniqKey="Yousef I" first="Ibrahim M." last="Yousef">Ibrahim M. Yousef</name><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation></author><author><name sortKey="Plaa, Gabriel L" sort="Plaa, Gabriel L" uniqKey="Plaa G" first="Gabriel L." last="Plaa">Gabriel L. Plaa</name><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation></author><author><name sortKey="Sharkawi, Mahmoud" sort="Sharkawi, Mahmoud" uniqKey="Sharkawi M" first="Mahmoud" last="Sharkawi">Mahmoud Sharkawi</name><affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology Letters</title><title level="j" type="abbrev">TOXLET</title><idno type="ISSN">0378-4274</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="39">39</biblScope><biblScope unit="page" to="47">47</biblScope></imprint><idno type="ISSN">0378-4274</idno></series><idno type="istex">C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</idno><idno type="DOI">10.1016/0378-4274(92)90061-N</idno><idno type="PII">0378-4274(92)90061-N</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-4274</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone.</title><author><name sortKey="Joseph, L D" sort="Joseph, L D" uniqKey="Joseph L" first="L D" last="Joseph">L D Joseph</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, University of Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Montreal</wicri:regionArea><wicri:noRegion>University of Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Yousef, I M" sort="Yousef, I M" uniqKey="Yousef I" first="I M" last="Yousef">I M Yousef</name></author><author><name sortKey="Plaa, G L" sort="Plaa, G L" uniqKey="Plaa G" first="G L" last="Plaa">G L Plaa</name></author><author><name sortKey="Sharkawi, M" sort="Sharkawi, M" uniqKey="Sharkawi M" first="M" last="Sharkawi">M. Sharkawi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1609437</idno><idno type="pmid">1609437</idno><idno type="wicri:Area/PubMed/Corpus">002196</idno><idno type="wicri:Area/PubMed/Curation">002196</idno><idno type="wicri:Area/PubMed/Checkpoint">001F14</idno><idno type="wicri:Area/Ncbi/Merge">000784</idno><idno type="wicri:Area/Ncbi/Curation">000784</idno><idno type="wicri:Area/Ncbi/Checkpoint">000784</idno><idno type="wicri:doubleKey">0378-4274:1992:Joseph L:potentiation:of:lithocholic</idno><idno type="wicri:Area/Main/Merge">009F07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone.</title><author><name sortKey="Joseph, L D" sort="Joseph, L D" uniqKey="Joseph L" first="L D" last="Joseph">L D Joseph</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, University of Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Montreal</wicri:regionArea><wicri:noRegion>University of Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Yousef, I M" sort="Yousef, I M" uniqKey="Yousef I" first="I M" last="Yousef">I M Yousef</name></author><author><name sortKey="Plaa, G L" sort="Plaa, G L" uniqKey="Plaa G" first="G L" last="Plaa">G L Plaa</name></author><author><name sortKey="Sharkawi, M" sort="Sharkawi, M" uniqKey="Sharkawi M" first="M" last="Sharkawi">M. Sharkawi</name></author></analytic><series><title level="j">Toxicology letters</title><idno type="ISSN">0378-4274</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bile Acids and Salts (secretion)</term><term>Bile Canaliculi (drug effects)</term><term>Bile Canaliculi (secretion)</term><term>Biological Transport (drug effects)</term><term>Body Weight (drug effects)</term><term>Cholestasis, Intrahepatic (chemically induced)</term><term>Drug Synergism</term><term>Lithocholic Acid (toxicity)</term><term>Male</term><term>Methyl n-Butyl Ketone (pharmacology)</term><term>Organ Size (drug effects)</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Taurocholic Acid (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Taurocholic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Methyl n-Butyl Ketone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Bile Acids and Salts</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cholestasis, Intrahepatic</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bile Canaliculi</term><term>Biological Transport</term><term>Body Weight</term><term>Organ Size</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Bile Canaliculi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Lithocholic Acid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Synergism</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 mumol/kg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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