Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone
Identifieur interne : 004334 ( Istex/Curation ); précédent : 004333; suivant : 004335Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone
Auteurs : Louis-Dumond Joseph ; Ibrahim M. Yousef ; Gabriel L. Plaa ; Mahmoud SharkawiSource :
- Toxicology Letters [ 0378-4274 ] ; 1992.
Abstract
Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.
Url:
DOI: 10.1016/0378-4274(92)90061-N
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Louis-Dumond Joseph<affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation><wicri:noCountry code="subField">MontrealCanada</wicri:noCountry></affiliation>Le document en format XML
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The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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