Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone
Identifieur interne : 004334 ( Istex/Corpus ); précédent : 004333; suivant : 004335Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone
Auteurs : Louis-Dumond Joseph ; Ibrahim M. Yousef ; Gabriel L. Plaa ; Mahmoud SharkawiSource :
- Toxicology Letters [ 0378-4274 ] ; 1992.
Abstract
Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.
Url:
DOI: 10.1016/0378-4274(92)90061-N
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Plaa</name><affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation></affiliation></author><author><name sortKey="Sharkawi, Mahmoud" sort="Sharkawi, Mahmoud" uniqKey="Sharkawi M" first="Mahmoud" last="Sharkawi">Mahmoud Sharkawi</name><affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0378-4274(92)90061-N</idno><idno type="url">https://api.istex.fr/document/C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004334</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title><author><name sortKey="Joseph, Louis Dumond" sort="Joseph, Louis Dumond" uniqKey="Joseph L" first="Louis-Dumond" last="Joseph">Louis-Dumond Joseph</name><affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation></affiliation></author><author><name sortKey="Yousef, Ibrahim M" sort="Yousef, Ibrahim M" uniqKey="Yousef I" first="Ibrahim M." last="Yousef">Ibrahim M. 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Plaa</name><affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation></affiliation></author><author><name sortKey="Sharkawi, Mahmoud" sort="Sharkawi, Mahmoud" uniqKey="Sharkawi M" first="Mahmoud" last="Sharkawi">Mahmoud Sharkawi</name><affiliation><mods:affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology Letters</title><title level="j" type="abbrev">TOXLET</title><idno type="ISSN">0378-4274</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="39">39</biblScope><biblScope unit="page" to="47">47</biblScope></imprint><idno type="ISSN">0378-4274</idno></series><idno type="istex">C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</idno><idno type="DOI">10.1016/0378-4274(92)90061-N</idno><idno type="PII">0378-4274(92)90061-N</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-4274</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Louis-Dumond Joseph</name><affiliations><json:string>Department of Pharmacology, University of Montreal, MontrealCanada</json:string></affiliations></json:item><json:item><name>Ibrahim M. Yousef</name><affiliations><json:string>Department of Pharmacology, University of Montreal, MontrealCanada</json:string></affiliations></json:item><json:item><name>Gabriel L. Plaa</name><affiliations><json:string>Department of Pharmacology, University of Montreal, MontrealCanada</json:string></affiliations></json:item><json:item><name>Mahmoud Sharkawi</name><affiliations><json:string>Department of Pharmacology, University of Montreal, MontrealCanada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Liver</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cholestasis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Bile acids</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Bile flow</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lithocholic acid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Methyl isobutyl ketone</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</abstract><qualityIndicators><score>3.93</score><pdfVersion>1.2</pdfVersion><pdfPageSize>432 x 648 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>893</abstractCharCount><pdfWordCount>2466</pdfWordCount><pdfCharCount>15453</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>122</abstractWordCount></qualityIndicators><title>Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title><pii><json:string>0378-4274(92)90061-N</json:string></pii><genre><json:string>research-article</json:string></genre><serie><genre></genre><language><json:string>unknown</json:string></language><title>Thèse de doctorat</title></serie><host><volume>61</volume><pii><json:string>S0378-4274(00)X0277-9</json:string></pii><pages><last>47</last><first>39</first></pages><issn><json:string>0378-4274</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Toxicology Letters</title><publicationDate>1992</publicationDate></host><categories><wos><json:string>TOXICOLOGY</json:string><json:string>TRANSPLANTATION</json:string></wos></categories><publicationDate>1992</publicationDate><copyrightDate>1992</copyrightDate><doi><json:string>10.1016/0378-4274(92)90061-N</json:string></doi><id>C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</id><score>1</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1992</date></publicationStmt><notesStmt><note>This work was part of M.Sc. thesis in parhamacology by Louis-Dumond Joseph.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title><author><persName><forename type="first">Louis-Dumond</forename><surname>Joseph</surname></persName><affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</affiliation></author><author><persName><forename type="first">Ibrahim M.</forename><surname>Yousef</surname></persName><note type="correspondence"><p>Correspondence to: Dr. Ibrahim Yousef, Department of Pharmacology, University of Montreal C.P. 6128, Succ. A.,Montreal, Quebec, Canada H3C 3J7.</p></note><affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</affiliation></author><author><persName><forename type="first">Gabriel L.</forename><surname>Plaa</surname></persName><affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</affiliation></author><author><persName><forename type="first">Mahmoud</forename><surname>Sharkawi</surname></persName><affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</affiliation></author></analytic><monogr><title level="j">Toxicology Letters</title><title level="j" type="abbrev">TOXLET</title><idno type="pISSN">0378-4274</idno><idno type="PII">S0378-4274(00)X0277-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992"></date><biblScope unit="volume">61</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="39">39</biblScope><biblScope unit="page" to="47">47</biblScope></imprint></monogr><idno type="istex">C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</idno><idno type="DOI">10.1016/0378-4274(92)90061-N</idno><idno type="PII">0378-4274(92)90061-N</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1992</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Liver</term></item><item><term>Cholestasis</term></item><item><term>Bile acids</term></item><item><term>Bile flow</term></item><item><term>Lithocholic acid</term></item><item><term>Methyl isobutyl ketone</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1992-01-12">Registration</change><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TOXLET</jid><aid>9290061N</aid><ce:pii>0378-4274(92)90061-N</ce:pii><ce:doi>10.1016/0378-4274(92)90061-N</ce:doi><ce:copyright type="unknown" year="1992"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This work was part of M.Sc. thesis in parhamacology by Louis-Dumond Joseph.</ce:note-para></ce:article-footnote><ce:title>Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</ce:title><ce:author-group><ce:author><ce:given-name>Louis-Dumond</ce:given-name><ce:surname>Joseph</ce:surname></ce:author><ce:author><ce:given-name>Ibrahim M.</ce:given-name><ce:surname>Yousef</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Gabriel L.</ce:given-name><ce:surname>Plaa</ce:surname></ce:author><ce:author><ce:given-name>Mahmoud</ce:given-name><ce:surname>Sharkawi</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Pharmacology, University of Montreal, MontrealCanada</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Correspondence to: Dr. Ibrahim Yousef, Department of Pharmacology, University of Montreal C.P. 6128, Succ. A.,Montreal, Quebec, Canada H3C 3J7.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="4" month="9" year="1991"></ce:date-received><ce:date-accepted day="12" month="1" year="1992"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 <math altimg="si1.gif"><fr shape="sol"><nu>μmol</nu><de>kg</de></fr></math> body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Liver</ce:text></ce:keyword><ce:keyword><ce:text>Cholestasis</ce:text></ce:keyword><ce:keyword><ce:text>Bile acids</ce:text></ce:keyword><ce:keyword><ce:text>Bile flow</ce:text></ce:keyword><ce:keyword><ce:text>Lithocholic acid</ce:text></ce:keyword><ce:keyword><ce:text>Methyl isobutyl ketone</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone</title></titleInfo><name type="personal"><namePart type="given">Louis-Dumond</namePart><namePart type="family">Joseph</namePart><affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ibrahim M.</namePart><namePart type="family">Yousef</namePart><affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</affiliation><description>Correspondence to: Dr. Ibrahim Yousef, Department of Pharmacology, University of Montreal C.P. 6128, Succ. A.,Montreal, Quebec, Canada H3C 3J7.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gabriel L.</namePart><namePart type="family">Plaa</namePart><affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mahmoud</namePart><namePart type="family">Sharkawi</namePart><affiliation>Department of Pharmacology, University of Montreal, MontrealCanada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><dateValid encoding="w3cdtf">1992-01-12</dateValid><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 μmolkg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</abstract><note>This work was part of M.Sc. thesis in parhamacology by Louis-Dumond Joseph.</note><subject><genre>Keywords</genre><topic>Liver</topic><topic>Cholestasis</topic><topic>Bile acids</topic><topic>Bile flow</topic><topic>Lithocholic acid</topic><topic>Methyl isobutyl ketone</topic></subject><relatedItem type="host"><titleInfo><title>Toxicology Letters</title></titleInfo><titleInfo type="abbreviated"><title>TOXLET</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199206</dateIssued></originInfo><identifier type="ISSN">0378-4274</identifier><identifier type="PII">S0378-4274(00)X0277-9</identifier><part><date>199206</date><detail type="volume"><number>61</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>123</end></extent><extent unit="pages"><start>39</start><end>47</end></extent></part></relatedItem><identifier type="istex">C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5</identifier><identifier type="DOI">10.1016/0378-4274(92)90061-N</identifier><identifier type="PII">0378-4274(92)90061-N</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/C7C3204AE3DD5F81F87CA6D51DF195084A2F8CE5/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">TOXICOLOGY</classCode><classCode scheme="WOS">TRANSPLANTATION</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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