Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone.
Identifieur interne : 000784 ( Ncbi/Merge ); précédent : 000783; suivant : 000785Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone.
Auteurs : L D Joseph [Canada] ; I M Yousef ; G L Plaa ; M. SharkawiSource :
- Toxicology letters [ 0378-4274 ] ; 1992.
English descriptors
- KwdEn :
- Animals, Bile Acids and Salts (secretion), Bile Canaliculi (drug effects), Bile Canaliculi (secretion), Biological Transport (drug effects), Body Weight (drug effects), Cholestasis, Intrahepatic (chemically induced), Drug Synergism, Lithocholic Acid (toxicity), Male, Methyl n-Butyl Ketone (pharmacology), Organ Size (drug effects), Rats, Rats, Inbred Strains, Taurocholic Acid (metabolism).
- MESH :
- chemical , metabolism : Taurocholic Acid.
- chemical , pharmacology : Methyl n-Butyl Ketone.
- chemical , secretion : Bile Acids and Salts.
- chemically induced : Cholestasis, Intrahepatic.
- drug effects : Bile Canaliculi, Biological Transport, Body Weight, Organ Size.
- secretion : Bile Canaliculi.
- chemical , toxicity : Lithocholic Acid.
- Animals, Drug Synergism, Male, Rats, Rats, Inbred Strains.
Abstract
Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 mumol/kg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.
PubMed: 1609437
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pubmed:1609437Le document en format XML
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Sharkawi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1609437</idno><idno type="pmid">1609437</idno><idno type="wicri:Area/PubMed/Corpus">002196</idno><idno type="wicri:Area/PubMed/Curation">002196</idno><idno type="wicri:Area/PubMed/Checkpoint">001F14</idno><idno type="wicri:Area/Ncbi/Merge">000784</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone.</title><author><name sortKey="Joseph, L D" sort="Joseph, L D" uniqKey="Joseph L" first="L D" last="Joseph">L D Joseph</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, University of Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Montreal</wicri:regionArea><wicri:noRegion>University of Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Yousef, I M" sort="Yousef, I M" uniqKey="Yousef I" first="I M" last="Yousef">I M Yousef</name></author><author><name sortKey="Plaa, G L" sort="Plaa, G L" uniqKey="Plaa G" first="G L" last="Plaa">G L Plaa</name></author><author><name sortKey="Sharkawi, M" sort="Sharkawi, M" uniqKey="Sharkawi M" first="M" last="Sharkawi">M. Sharkawi</name></author></analytic><series><title level="j">Toxicology letters</title><idno type="ISSN">0378-4274</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bile Acids and Salts (secretion)</term><term>Bile Canaliculi (drug effects)</term><term>Bile Canaliculi (secretion)</term><term>Biological Transport (drug effects)</term><term>Body Weight (drug effects)</term><term>Cholestasis, Intrahepatic (chemically induced)</term><term>Drug Synergism</term><term>Lithocholic Acid (toxicity)</term><term>Male</term><term>Methyl n-Butyl Ketone (pharmacology)</term><term>Organ Size (drug effects)</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Taurocholic Acid (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Taurocholic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Methyl n-Butyl Ketone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Bile Acids and Salts</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cholestasis, Intrahepatic</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bile Canaliculi</term><term>Biological Transport</term><term>Body Weight</term><term>Organ Size</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Bile Canaliculi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Lithocholic Acid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Synergism</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 mumol/kg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">1609437</PMID><DateCreated><Year>1992</Year><Month>07</Month><Day>21</Day></DateCreated><DateCompleted><Year>1992</Year><Month>07</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0378-4274</ISSN><JournalIssue CitedMedium="Print"><Volume>61</Volume><Issue>1</Issue><PubDate><Year>1992</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Toxicology letters</Title><ISOAbbreviation>Toxicol. Lett.</ISOAbbreviation></Journal><ArticleTitle>Potentiation of lithocholic-acid-induced cholestasis by methyl isobutyl ketone.</ArticleTitle><Pagination><MedlinePgn>39-47</MedlinePgn></Pagination><Abstract><AbstractText>Methyl isobutyl ketone was found to potentiate intrahepatic cholestasis induced by taurolithocholate and the combination of manganese-bilirubin. The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. Male rats were given methyl isobutyl ketone 7.5 mumol/kg body wt. daily for 3 days. The effect of this treatment on lithocholate-induced cholestasis, bile formation and taurocholic acid transport was examined. The data showed that methyl isobutyl ketone treatment potentiated lithocholate-induced cholestasis and reduced significantly bile salt, phospholipid and cholesterol secretion rates as well as the transport maximum of taurocholic acid. It is suggested that methyl isobutyl ketone potentiates lithocholate-induced cholestasis by reducing the bile salt pool and interfering with the haptic secretion rate of bile salts.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Joseph</LastName><ForeName>L D</ForeName><Initials>LD</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, University of Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yousef</LastName><ForeName>I M</ForeName><Initials>IM</Initials></Author><Author ValidYN="Y"><LastName>Plaa</LastName><ForeName>G L</ForeName><Initials>GL</Initials></Author><Author ValidYN="Y"><LastName>Sharkawi</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>NETHERLANDS</Country><MedlineTA>Toxicol Lett</MedlineTA><NlmUniqueID>7709027</NlmUniqueID><ISSNLinking>0378-4274</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001647">Bile Acids and Salts</NameOfSubstance></Chemical><Chemical><RegistryNumber>5E090O0G3Z</RegistryNumber><NameOfSubstance UI="D013656">Taurocholic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>5QU0I8393U</RegistryNumber><NameOfSubstance UI="D008095">Lithocholic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>6QDY60NH6N</RegistryNumber><NameOfSubstance UI="D008742">Methyl n-Butyl Ketone</NameOfSubstance></Chemical><Chemical><RegistryNumber>U5T7B88CNP</RegistryNumber><NameOfSubstance UI="C005458">methyl isobutyl ketone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001647">Bile Acids and Salts</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000557">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001648">Bile Canaliculi</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000557">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001692">Biological Transport</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001835">Body Weight</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002780">Cholestasis, Intrahepatic</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000139">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004357">Drug Synergism</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008095">Lithocholic Acid</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000633">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008742">Methyl n-Butyl Ketone</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009929">Organ Size</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011919">Rats, Inbred Strains</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013656">Taurocholic Acid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1609437</ArticleId><ArticleId IdType="pii">0378-4274(92)90061-N</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Plaa, G L" sort="Plaa, G L" uniqKey="Plaa G" first="G L" last="Plaa">G L Plaa</name><name sortKey="Sharkawi, M" sort="Sharkawi, M" uniqKey="Sharkawi M" first="M" last="Sharkawi">M. Sharkawi</name><name sortKey="Yousef, I M" sort="Yousef, I M" uniqKey="Yousef I" first="I M" last="Yousef">I M Yousef</name></noCountry><country name="Canada"><noRegion><name sortKey="Joseph, L D" sort="Joseph, L D" uniqKey="Joseph L" first="L D" last="Joseph">L D Joseph</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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