Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)
Identifieur interne : 000C93 ( Ncbi/Merge ); précédent : 000C92; suivant : 000C94Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)
Auteurs : Ken Yan Ching Chow ; Chung Chau Hon ; Raymond Kin Hi Hui ; Raymond Tsz Yeung Wong ; Chi Wai Yip ; Fanya Zeng ; Frederick Chi Ching LeungSource :
- Genomics, Proteomics & Bioinformatics [ 1672-0229 ] ; 2003.
Descripteurs français
- KwdFr :
- Animaux, Conception de médicament, Humains, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Vaccins antiviraux, Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (isolement et purification), Évolution moléculaire.
- MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- génétique : Virus du SRAS.
- immunologie : Virus du SRAS.
- isolement et purification : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère.
- Animaux, Conception de médicament, Humains, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals, Drug Design, Evolution, Molecular, Humans, SARS Virus (genetics), SARS Virus (immunology), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (virology), Viral Vaccines.
- MESH :
- chemical : Viral Vaccines.
- diagnosis : Severe Acute Respiratory Syndrome.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- immunology : SARS Virus.
- isolation & purification : SARS Virus.
- therapy : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Drug Design, Evolution, Molecular, Humans.
Abstract
The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.
Url:
DOI: 10.1016/S1672-0229(03)01031-3
PubMed: 15629054
PubMed Central: 5172416
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001778
- to stream Pmc, to step Curation: 001778
- to stream Pmc, to step Checkpoint: 001877
- to stream PubMed, to step Corpus: 002972
- to stream PubMed, to step Curation: 002972
- to stream PubMed, to step Checkpoint: 003180
Links to Exploration step
PMC:5172416Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)</title><author><name sortKey="Chow, Ken Yan Ching" sort="Chow, Ken Yan Ching" uniqKey="Chow K" first="Ken Yan Ching" last="Chow">Ken Yan Ching Chow</name></author><author><name sortKey="Hon, Chung Chau" sort="Hon, Chung Chau" uniqKey="Hon C" first="Chung Chau" last="Hon">Chung Chau Hon</name></author><author><name sortKey="Hui, Raymond Kin Hi" sort="Hui, Raymond Kin Hi" uniqKey="Hui R" first="Raymond Kin Hi" last="Hui">Raymond Kin Hi Hui</name></author><author><name sortKey="Wong, Raymond Tsz Yeung" sort="Wong, Raymond Tsz Yeung" uniqKey="Wong R" first="Raymond Tsz Yeung" last="Wong">Raymond Tsz Yeung Wong</name></author><author><name sortKey="Yip, Chi Wai" sort="Yip, Chi Wai" uniqKey="Yip C" first="Chi Wai" last="Yip">Chi Wai Yip</name></author><author><name sortKey="Zeng, Fanya" sort="Zeng, Fanya" uniqKey="Zeng F" first="Fanya" last="Zeng">Fanya Zeng</name></author><author><name sortKey="Leung, Frederick Chi Ching" sort="Leung, Frederick Chi Ching" uniqKey="Leung F" first="Frederick Chi Ching" last="Leung">Frederick Chi Ching Leung</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15629054</idno><idno type="pmc">5172416</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172416</idno><idno type="RBID">PMC:5172416</idno><idno type="doi">10.1016/S1672-0229(03)01031-3</idno><date when="2003">2003</date><idno type="wicri:Area/Pmc/Corpus">001778</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001778</idno><idno type="wicri:Area/Pmc/Curation">001778</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001778</idno><idno type="wicri:Area/Pmc/Checkpoint">001877</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001877</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:15629054</idno><idno type="wicri:Area/PubMed/Corpus">002972</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002972</idno><idno type="wicri:Area/PubMed/Curation">002972</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002972</idno><idno type="wicri:Area/PubMed/Checkpoint">003180</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003180</idno><idno type="wicri:Area/Ncbi/Merge">000C93</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)</title><author><name sortKey="Chow, Ken Yan Ching" sort="Chow, Ken Yan Ching" uniqKey="Chow K" first="Ken Yan Ching" last="Chow">Ken Yan Ching Chow</name></author><author><name sortKey="Hon, Chung Chau" sort="Hon, Chung Chau" uniqKey="Hon C" first="Chung Chau" last="Hon">Chung Chau Hon</name></author><author><name sortKey="Hui, Raymond Kin Hi" sort="Hui, Raymond Kin Hi" uniqKey="Hui R" first="Raymond Kin Hi" last="Hui">Raymond Kin Hi Hui</name></author><author><name sortKey="Wong, Raymond Tsz Yeung" sort="Wong, Raymond Tsz Yeung" uniqKey="Wong R" first="Raymond Tsz Yeung" last="Wong">Raymond Tsz Yeung Wong</name></author><author><name sortKey="Yip, Chi Wai" sort="Yip, Chi Wai" uniqKey="Yip C" first="Chi Wai" last="Yip">Chi Wai Yip</name></author><author><name sortKey="Zeng, Fanya" sort="Zeng, Fanya" uniqKey="Zeng F" first="Fanya" last="Zeng">Fanya Zeng</name></author><author><name sortKey="Leung, Frederick Chi Ching" sort="Leung, Frederick Chi Ching" uniqKey="Leung F" first="Frederick Chi Ching" last="Leung">Frederick Chi Ching Leung</name></author></analytic><series><title level="j">Genomics, Proteomics & Bioinformatics</title><idno type="ISSN">1672-0229</idno><idno type="eISSN">2210-3244</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Drug Design</term><term>Evolution, Molecular</term><term>Humans</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (therapy)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Vaccines</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Conception de médicament</term><term>Humains</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Vaccins antiviraux</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (isolement et purification)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Design</term><term>Evolution, Molecular</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conception de médicament</term><term>Humains</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhong, N S" uniqKey="Zhong N">N.S. Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casais, R" uniqKey="Casais R">R. Casais</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haijema, B J" uniqKey="Haijema B">B.J. Haijema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sstadler, K" uniqKey="Sstadler K">K. Sstadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K.V. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellis, J S" uniqKey="Ellis J">J.S. Ellis</name></author><author><name sortKey="Zambon, M C" uniqKey="Zambon M">M.C. Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, M A" uniqKey="Marra M">M.A. Marra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, F Y" uniqKey="Zeng F">F.Y. Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, F C" uniqKey="Leung F">F.C. Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D. Cavanagh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K.V. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, F" uniqKey="Gao F">F. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanner, J A" uniqKey="Tanner J">J.A. Tanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J X" uniqKey="Li J">J.X. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spiga, O" uniqKey="Spiga O">O. Spiga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, L" uniqKey="Yan L">L. Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krokhin, O" uniqKey="Krokhin O">O. Krokhin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, X" uniqKey="Xiao X">X. Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, X" uniqKey="Shen X">X. Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Q F" uniqKey="Wu Q">Q.F. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, Y W" uniqKey="Hu Y">Y.W. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J Q" uniqKey="Wang J">J.Q. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, R" uniqKey="He R">R. He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J Q" uniqKey="Wang J">J.Q. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Y" uniqKey="Lin Y">Y. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rest, J S" uniqKey="Rest J">J.S. Rest</name></author><author><name sortKey="Mindell, D P" uniqKey="Mindell D">D.P. Mindell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K.V. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, R J" uniqKey="De Groot R">R.J. de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kennedy, M" uniqKey="Kennedy M">M. Kennedy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamanaka, M" uniqKey="Yamanaka M">M. Yamanaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horsburgh, B C" uniqKey="Horsburgh B">B.C. Horsburgh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rasschaert, D" uniqKey="Rasschaert D">D. Rasschaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaughn, E M" uniqKey="Vaughn E">E.M. Vaughn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duarte, M" uniqKey="Duarte M">M. Duarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duarte, M" uniqKey="Duarte M">M. Duarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bridgen, A" uniqKey="Bridgen A">A. Bridgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S.R. Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, D" uniqKey="Yoo D">D. Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abraham, S" uniqKey="Abraham S">S. Abraham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sasseville, A M" uniqKey="Sasseville A">A.M. Sasseville</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mounir, S" uniqKey="Mounir S">S. Mounir</name></author><author><name sortKey="Talbot, P J" uniqKey="Talbot P">P.J. Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vieler, E" uniqKey="Vieler E">E. Vieler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breslin, J J" uniqKey="Breslin J">J.J. Breslin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breslin, J J" uniqKey="Breslin J">J.J. Breslin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeek, A" uniqKey="Verbeek A">A. Verbeek</name></author><author><name sortKey="Tijssen, P" uniqKey="Tijssen P">P. Tijssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boursnell, M E" uniqKey="Boursnell M">M.E. Boursnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D. Cavanagh</name></author><author><name sortKey="Davis, P J" uniqKey="Davis P">P.J. Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, W N" uniqKey="Jia W">W.N. Jia</name></author><author><name sortKey="Naqi, S A" uniqKey="Naqi S">S.A. Naqi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jonassen, C M" uniqKey="Jonassen C">C.M. Jonassen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luytjes, W" uniqKey="Luytjes W">W. Luytjes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrewegh, A A" uniqKey="Herrewegh A">A.A. Herrewegh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Onnor, J B" uniqKey="O Onnor J">J.B. O’Connor</name></author><author><name sortKey="Brain, D A" uniqKey="Brain D">D.A. Brain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, L" uniqKey="Kuo L">L. Kuo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez, C M" uniqKey="Sanchez C">C.M. Sanchez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C W" uniqKey="Lee C">C.W. Lee</name></author><author><name sortKey="Jackwood, M W" uniqKey="Jackwood M">M.W. Jackwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rowe, C L" uniqKey="Rowe C">C.L. Rowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martina, B E" uniqKey="Martina B">B.E. Martina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Normile, D" uniqKey="Normile D">D. Normile</name></author><author><name sortKey="Enserink, M" uniqKey="Enserink M">M. Enserink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koetzner, C A" uniqKey="Koetzner C">C.A. Koetzner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, M" uniqKey="Lin M">M. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yam, W C" uniqKey="Yam W">W.C. Yam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaila, M S" uniqKey="Shaila M">M.S. Shaila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, E K" uniqKey="Ng E">E.K. Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y S" uniqKey="Wang Y">Y.S. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, X Y" uniqKey="Che X">X.Y. Che</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, E C" uniqKey="Holmes E">E.C. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, T M" uniqKey="Gallagher T">T.M. Gallagher</name></author><author><name sortKey="Buchmeier, M J" uniqKey="Buchmeier M">M.J. Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phillips, J J" uniqKey="Phillips J">J.J. Phillips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hays, J P" uniqKey="Hays J">J.P. Hays</name></author><author><name sortKey="Myint, S H" uniqKey="Myint S">S.H. Myint</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C W" uniqKey="Lee C">C.W. Lee</name></author><author><name sortKey="Jackwood, M W" uniqKey="Jackwood M">M.W. Jackwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruan, Y J" uniqKey="Ruan Y">Y.J. Ruan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsui, S K" uniqKey="Tsui S">S.K. Tsui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiu, R W" uniqKey="Chiu R">R.W. Chiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chim, S S" uniqKey="Chim S">S.S. Chim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, F Y" uniqKey="Zeng F">F.Y. Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korber, B" uniqKey="Korber B">B. Korber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, X" uniqKey="Tang X">X. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, K H" uniqKey="Chen K">K.H. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Herdt, P" uniqKey="De Herdt P">P. de Herdt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D. Cavanagh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, A S" uniqKey="De Groot A">A.S. de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campanacci, V" uniqKey="Campanacci V">V. Campanacci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, K C" uniqKey="Chou K">K.C. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, K" uniqKey="Fan K">K. Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Grotthuss, M" uniqKey="Von Grotthuss M">M. von Grotthuss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knudsen, T B" uniqKey="Knudsen T">T.B. Knudsen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="15629054"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)</title><author><name sortKey="Chow, Ken Yan Ching" sort="Chow, Ken Yan Ching" uniqKey="Chow K" first="Ken Yan Ching" last="Chow">Ken Yan Ching Chow</name></author><author><name sortKey="Hon, Chung Chau" sort="Hon, Chung Chau" uniqKey="Hon C" first="Chung Chau" last="Hon">Chung Chau Hon</name></author><author><name sortKey="Hui, Raymond Kin Hi" sort="Hui, Raymond Kin Hi" uniqKey="Hui R" first="Raymond Kin Hi" last="Hui">Raymond Kin Hi Hui</name></author><author><name sortKey="Wong, Raymond Tsz Yeung" sort="Wong, Raymond Tsz Yeung" uniqKey="Wong R" first="Raymond Tsz Yeung" last="Wong">Raymond Tsz Yeung Wong</name></author><author><name sortKey="Yip, Chi Wai" sort="Yip, Chi Wai" uniqKey="Yip C" first="Chi Wai" last="Yip">Chi Wai Yip</name></author><author><name sortKey="Zeng, Fanya" sort="Zeng, Fanya" uniqKey="Zeng F" first="Fanya" last="Zeng">Fanya Zeng</name></author><author><name sortKey="Leung, Frederick Chi Ching" sort="Leung, Frederick Chi Ching" uniqKey="Leung F" first="Frederick Chi Ching" last="Leung">Frederick Chi Ching Leung</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15629054</idno><idno type="pmc">5172416</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172416</idno><idno type="RBID">PMC:5172416</idno><idno type="doi">10.1016/S1672-0229(03)01031-3</idno><date when="2003">2003</date><idno type="wicri:Area/Pmc/Corpus">001778</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001778</idno><idno type="wicri:Area/Pmc/Curation">001778</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001778</idno><idno type="wicri:Area/Pmc/Checkpoint">001877</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001877</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)</title><author><name sortKey="Chow, Ken Yan Ching" sort="Chow, Ken Yan Ching" uniqKey="Chow K" first="Ken Yan Ching" last="Chow">Ken Yan Ching Chow</name></author><author><name sortKey="Hon, Chung Chau" sort="Hon, Chung Chau" uniqKey="Hon C" first="Chung Chau" last="Hon">Chung Chau Hon</name></author><author><name sortKey="Hui, Raymond Kin Hi" sort="Hui, Raymond Kin Hi" uniqKey="Hui R" first="Raymond Kin Hi" last="Hui">Raymond Kin Hi Hui</name></author><author><name sortKey="Wong, Raymond Tsz Yeung" sort="Wong, Raymond Tsz Yeung" uniqKey="Wong R" first="Raymond Tsz Yeung" last="Wong">Raymond Tsz Yeung Wong</name></author><author><name sortKey="Yip, Chi Wai" sort="Yip, Chi Wai" uniqKey="Yip C" first="Chi Wai" last="Yip">Chi Wai Yip</name></author><author><name sortKey="Zeng, Fanya" sort="Zeng, Fanya" uniqKey="Zeng F" first="Fanya" last="Zeng">Fanya Zeng</name></author><author><name sortKey="Leung, Frederick Chi Ching" sort="Leung, Frederick Chi Ching" uniqKey="Leung F" first="Frederick Chi Ching" last="Leung">Frederick Chi Ching Leung</name></author></analytic><series><title level="j">Genomics, Proteomics & Bioinformatics</title><idno type="ISSN">1672-0229</idno><idno type="eISSN">2210-3244</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhong, N S" uniqKey="Zhong N">N.S. Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casais, R" uniqKey="Casais R">R. Casais</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haijema, B J" uniqKey="Haijema B">B.J. Haijema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sstadler, K" uniqKey="Sstadler K">K. Sstadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K.V. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellis, J S" uniqKey="Ellis J">J.S. Ellis</name></author><author><name sortKey="Zambon, M C" uniqKey="Zambon M">M.C. Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, M A" uniqKey="Marra M">M.A. Marra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, F Y" uniqKey="Zeng F">F.Y. Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, F C" uniqKey="Leung F">F.C. Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D. Cavanagh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K.V. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, F" uniqKey="Gao F">F. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanner, J A" uniqKey="Tanner J">J.A. Tanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J X" uniqKey="Li J">J.X. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spiga, O" uniqKey="Spiga O">O. Spiga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, L" uniqKey="Yan L">L. Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krokhin, O" uniqKey="Krokhin O">O. Krokhin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, X" uniqKey="Xiao X">X. Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, X" uniqKey="Shen X">X. Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Q F" uniqKey="Wu Q">Q.F. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, Y W" uniqKey="Hu Y">Y.W. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J Q" uniqKey="Wang J">J.Q. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, R" uniqKey="He R">R. He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J Q" uniqKey="Wang J">J.Q. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Y" uniqKey="Lin Y">Y. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rest, J S" uniqKey="Rest J">J.S. Rest</name></author><author><name sortKey="Mindell, D P" uniqKey="Mindell D">D.P. Mindell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author><author><name sortKey="Holmes, K V" uniqKey="Holmes K">K.V. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, R J" uniqKey="De Groot R">R.J. de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kennedy, M" uniqKey="Kennedy M">M. Kennedy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamanaka, M" uniqKey="Yamanaka M">M. Yamanaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horsburgh, B C" uniqKey="Horsburgh B">B.C. Horsburgh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rasschaert, D" uniqKey="Rasschaert D">D. Rasschaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaughn, E M" uniqKey="Vaughn E">E.M. Vaughn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duarte, M" uniqKey="Duarte M">M. Duarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duarte, M" uniqKey="Duarte M">M. Duarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bridgen, A" uniqKey="Bridgen A">A. Bridgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S.R. Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, D" uniqKey="Yoo D">D. Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abraham, S" uniqKey="Abraham S">S. Abraham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sasseville, A M" uniqKey="Sasseville A">A.M. Sasseville</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mounir, S" uniqKey="Mounir S">S. Mounir</name></author><author><name sortKey="Talbot, P J" uniqKey="Talbot P">P.J. Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vieler, E" uniqKey="Vieler E">E. Vieler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breslin, J J" uniqKey="Breslin J">J.J. Breslin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breslin, J J" uniqKey="Breslin J">J.J. Breslin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeek, A" uniqKey="Verbeek A">A. Verbeek</name></author><author><name sortKey="Tijssen, P" uniqKey="Tijssen P">P. Tijssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boursnell, M E" uniqKey="Boursnell M">M.E. Boursnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D. Cavanagh</name></author><author><name sortKey="Davis, P J" uniqKey="Davis P">P.J. Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, W N" uniqKey="Jia W">W.N. Jia</name></author><author><name sortKey="Naqi, S A" uniqKey="Naqi S">S.A. Naqi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jonassen, C M" uniqKey="Jonassen C">C.M. Jonassen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, M M" uniqKey="Lai M">M.M. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luytjes, W" uniqKey="Luytjes W">W. Luytjes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrewegh, A A" uniqKey="Herrewegh A">A.A. Herrewegh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Onnor, J B" uniqKey="O Onnor J">J.B. O’Connor</name></author><author><name sortKey="Brain, D A" uniqKey="Brain D">D.A. Brain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, L" uniqKey="Kuo L">L. Kuo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez, C M" uniqKey="Sanchez C">C.M. Sanchez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C W" uniqKey="Lee C">C.W. Lee</name></author><author><name sortKey="Jackwood, M W" uniqKey="Jackwood M">M.W. Jackwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rowe, C L" uniqKey="Rowe C">C.L. Rowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martina, B E" uniqKey="Martina B">B.E. Martina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Normile, D" uniqKey="Normile D">D. Normile</name></author><author><name sortKey="Enserink, M" uniqKey="Enserink M">M. Enserink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koetzner, C A" uniqKey="Koetzner C">C.A. Koetzner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, M" uniqKey="Lin M">M. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yam, W C" uniqKey="Yam W">W.C. Yam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaila, M S" uniqKey="Shaila M">M.S. Shaila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, E K" uniqKey="Ng E">E.K. Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y S" uniqKey="Wang Y">Y.S. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che, X Y" uniqKey="Che X">X.Y. Che</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, E C" uniqKey="Holmes E">E.C. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, T M" uniqKey="Gallagher T">T.M. Gallagher</name></author><author><name sortKey="Buchmeier, M J" uniqKey="Buchmeier M">M.J. Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phillips, J J" uniqKey="Phillips J">J.J. Phillips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hays, J P" uniqKey="Hays J">J.P. Hays</name></author><author><name sortKey="Myint, S H" uniqKey="Myint S">S.H. Myint</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C W" uniqKey="Lee C">C.W. Lee</name></author><author><name sortKey="Jackwood, M W" uniqKey="Jackwood M">M.W. Jackwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruan, Y J" uniqKey="Ruan Y">Y.J. Ruan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsui, S K" uniqKey="Tsui S">S.K. Tsui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiu, R W" uniqKey="Chiu R">R.W. Chiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chim, S S" uniqKey="Chim S">S.S. Chim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, F Y" uniqKey="Zeng F">F.Y. Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korber, B" uniqKey="Korber B">B. Korber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, X" uniqKey="Tang X">X. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, K H" uniqKey="Chen K">K.H. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Herdt, P" uniqKey="De Herdt P">P. de Herdt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D. Cavanagh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, A S" uniqKey="De Groot A">A.S. de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campanacci, V" uniqKey="Campanacci V">V. Campanacci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, K C" uniqKey="Chou K">K.C. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, K" uniqKey="Fan K">K. Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Grotthuss, M" uniqKey="Von Grotthuss M">M. von Grotthuss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knudsen, T B" uniqKey="Knudsen T">T.B. Knudsen</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).</title><author><name sortKey="Chow, Ken Yan Ching" sort="Chow, Ken Yan Ching" uniqKey="Chow K" first="Ken Yan Ching" last="Chow">Ken Yan Ching Chow</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Zoology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Hon, Chung Chau" sort="Hon, Chung Chau" uniqKey="Hon C" first="Chung Chau" last="Hon">Chung Chau Hon</name></author><author><name sortKey="Hui, Raymond Kin Hi" sort="Hui, Raymond Kin Hi" uniqKey="Hui R" first="Raymond Kin Hi" last="Hui">Raymond Kin Hi Hui</name></author><author><name sortKey="Wong, Raymond Tsz Yeung" sort="Wong, Raymond Tsz Yeung" uniqKey="Wong R" first="Raymond Tsz Yeung" last="Wong">Raymond Tsz Yeung Wong</name></author><author><name sortKey="Yip, Chi Wai" sort="Yip, Chi Wai" uniqKey="Yip C" first="Chi Wai" last="Yip">Chi Wai Yip</name></author><author><name sortKey="Zeng, Fanya" sort="Zeng, Fanya" uniqKey="Zeng F" first="Fanya" last="Zeng">Fanya Zeng</name></author><author><name sortKey="Leung, Frederick Chi Ching" sort="Leung, Frederick Chi Ching" uniqKey="Leung F" first="Frederick Chi Ching" last="Leung">Frederick Chi Ching Leung</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:15629054</idno><idno type="pmid">15629054</idno><idno type="doi">10.1016/s1672-0229(03)01031-3</idno><idno type="wicri:Area/PubMed/Corpus">002972</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002972</idno><idno type="wicri:Area/PubMed/Curation">002972</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002972</idno><idno type="wicri:Area/PubMed/Checkpoint">003180</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003180</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).</title><author><name sortKey="Chow, Ken Yan Ching" sort="Chow, Ken Yan Ching" uniqKey="Chow K" first="Ken Yan Ching" last="Chow">Ken Yan Ching Chow</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Zoology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Hon, Chung Chau" sort="Hon, Chung Chau" uniqKey="Hon C" first="Chung Chau" last="Hon">Chung Chau Hon</name></author><author><name sortKey="Hui, Raymond Kin Hi" sort="Hui, Raymond Kin Hi" uniqKey="Hui R" first="Raymond Kin Hi" last="Hui">Raymond Kin Hi Hui</name></author><author><name sortKey="Wong, Raymond Tsz Yeung" sort="Wong, Raymond Tsz Yeung" uniqKey="Wong R" first="Raymond Tsz Yeung" last="Wong">Raymond Tsz Yeung Wong</name></author><author><name sortKey="Yip, Chi Wai" sort="Yip, Chi Wai" uniqKey="Yip C" first="Chi Wai" last="Yip">Chi Wai Yip</name></author><author><name sortKey="Zeng, Fanya" sort="Zeng, Fanya" uniqKey="Zeng F" first="Fanya" last="Zeng">Fanya Zeng</name></author><author><name sortKey="Leung, Frederick Chi Ching" sort="Leung, Frederick Chi Ching" uniqKey="Leung F" first="Frederick Chi Ching" last="Leung">Frederick Chi Ching Leung</name></author></analytic><series><title level="j">Genomics, proteomics & bioinformatics</title><idno type="ISSN">1672-0229</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Drug Design</term><term>Evolution, Molecular</term><term>Humans</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (therapy)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Vaccines</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Conception de médicament</term><term>Humains</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Vaccins antiviraux</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (isolement et purification)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Design</term><term>Evolution, Molecular</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conception de médicament</term><term>Humains</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C93 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000C93 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5172416
|texte= Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:15629054" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |