SrasV1, PubMed, Checkpoint, bibRecord, 003180

Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).

Identifieur interne : 003180 ( PubMed/Checkpoint ); précédent : 003179; suivant : 003181

Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).

Auteurs : Ken Yan Ching Chow [République populaire de Chine] ; Chung Chau Hon ; Raymond Kin Hi Hui ; Raymond Tsz Yeung Wong ; Chi Wai Yip ; Fanya Zeng ; Frederick Chi Ching Leung

Source :

Genomics, proteomics & bioinformatics [ 1672-0229 ] ; 2003.

RBID : pubmed:15629054

Descripteurs français

KwdFr :
- Animaux, Conception de médicament, Humains, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Vaccins antiviraux, Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (isolement et purification), Évolution moléculaire.
MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- génétique : Virus du SRAS.
- immunologie : Virus du SRAS.
- isolement et purification : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère.
- Animaux, Conception de médicament, Humains, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Évolution moléculaire.

English descriptors

KwdEn :
- Animals, Drug Design, Evolution, Molecular, Humans, SARS Virus (genetics), SARS Virus (immunology), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (virology), Viral Vaccines.
MESH :
- chemical : Viral Vaccines.
- diagnosis : Severe Acute Respiratory Syndrome.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- immunology : SARS Virus.
- isolation & purification : SARS Virus.
- therapy : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Drug Design, Evolution, Molecular, Humans.

Abstract

The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.

DOI: 10.1016/s1672-0229(03)01031-3
PubMed: 15629054

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002972
to stream PubMed, to step Curation: 002972

Links to Exploration step

pubmed:15629054

Le document en format XML

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<front><div type="abstract" xml:lang="en">The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.</div>
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<affiliations><list><country><li>République populaire de Chine</li>
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<name sortKey="Hui, Raymond Kin Hi" sort="Hui, Raymond Kin Hi" uniqKey="Hui R" first="Raymond Kin Hi" last="Hui">Raymond Kin Hi Hui</name>
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Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).

Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).

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