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Molecular pathology of emerging coronavirus infections

Identifieur interne : 002968 ( Ncbi/Curation ); précédent : 002967; suivant : 002969

Molecular pathology of emerging coronavirus infections

Auteurs : Lisa E. Gralinski ; Ralph S. Baric

Source :

RBID : PMC:4267971

Descripteurs français

English descriptors

Abstract

Abstract

Respiratory viruses can cause a wide spectrum of pulmonary diseases, ranging from mild, upper respiratory tract infections to severe and life‐threatening lower respiratory tract infections, including the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Viral clearance and subsequent recovery from infection require activation of an effective host immune response; however, many immune effector cells may also cause injury to host tissues. Severe acute respiratory syndrome (SARS) coronavirus and Middle East respiratory syndrome (MERS) coronavirus cause severe infection of the lower respiratory tract, with 10% and 35% overall mortality rates, respectively; however, >50% mortality rates are seen in the aged and immunosuppressed populations. While these viruses are susceptible to interferon treatment in vitro, they both encode numerous genes that allow for successful evasion of the host immune system until after high virus titres have been achieved. In this review, we discuss the importance of the innate immune response and the development of lung pathology following human coronavirus infection. © 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.


Url:
DOI: 10.1002/path.4454
PubMed: 25270030
PubMed Central: 4267971

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PMC:4267971

Le document en format XML

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<p id="path4454-para-0001">Respiratory viruses can cause a wide spectrum of pulmonary diseases, ranging from mild, upper respiratory tract infections to severe and life‐threatening lower respiratory tract infections, including the development of acute lung injury (
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