Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons☆
Identifieur interne : 002967 ( Ncbi/Curation ); précédent : 002966; suivant : 002968Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons☆
Auteurs : Fernando Almazán ; Isabel Sola ; Sonia Zu Iga ; Silvia Marquez-Jurado ; Lucia Morales ; Martina Becares ; Luis EnjuanesSource :
- Virus Research [ 0168-1702 ] ; 2014.
Abstract
The four different reverse genetic systems developed for CoVs are reviewed and discussed. These systems were based on the use of BACs, in vitro ligation and vaccinia virus as a vector. CoV reverse genetics is an essential tool for the study of CoV replication, virus–host interaction and pathogenesis. These reverse genetic systems allow the development of genetically defined vaccines and the analysis of antiviral drugs.
Url:
DOI: 10.1016/j.virusres.2014.09.006
PubMed: 25261606
PubMed Central: 7114485
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PMC:7114485Le document en format XML
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<author><name sortKey="Marquez Jurado, Silvia" sort="Marquez Jurado, Silvia" uniqKey="Marquez Jurado S" first="Silvia" last="Marquez-Jurado">Silvia Marquez-Jurado</name>
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<author><name sortKey="Morales, Lucia" sort="Morales, Lucia" uniqKey="Morales L" first="Lucia" last="Morales">Lucia Morales</name>
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<author><name sortKey="Becares, Martina" sort="Becares, Martina" uniqKey="Becares M" first="Martina" last="Becares">Martina Becares</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons<sup><xref ref-type="fn" rid="d32e998">☆</xref>
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<author><name sortKey="Almazan, Fernando" sort="Almazan, Fernando" uniqKey="Almazan F" first="Fernando" last="Almazán">Fernando Almazán</name>
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<author><name sortKey="Sola, Isabel" sort="Sola, Isabel" uniqKey="Sola I" first="Isabel" last="Sola">Isabel Sola</name>
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<author><name sortKey="Zu Iga, Sonia" sort="Zu Iga, Sonia" uniqKey="Zu Iga S" first="Sonia" last="Zu Iga">Sonia Zu Iga</name>
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<author><name sortKey="Marquez Jurado, Silvia" sort="Marquez Jurado, Silvia" uniqKey="Marquez Jurado S" first="Silvia" last="Marquez-Jurado">Silvia Marquez-Jurado</name>
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<author><name sortKey="Morales, Lucia" sort="Morales, Lucia" uniqKey="Morales L" first="Lucia" last="Morales">Lucia Morales</name>
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<author><name sortKey="Becares, Martina" sort="Becares, Martina" uniqKey="Becares M" first="Martina" last="Becares">Martina Becares</name>
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<author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
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<series><title level="j">Virus Research</title>
<idno type="ISSN">0168-1702</idno>
<idno type="eISSN">1872-7492</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">The four different reverse genetic systems developed for CoVs are reviewed and discussed.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">These systems were based on the use of BACs, in vitro ligation and vaccinia virus as a vector.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">CoV reverse genetics is an essential tool for the study of CoV replication, virus–host interaction and pathogenesis.</p>
</list-item>
<list-item id="lsti0020"><label>•</label>
<p id="par0020">These reverse genetic systems allow the development of genetically defined vaccines and the analysis of antiviral drugs.</p>
</list-item>
</list>
</p>
</div>
</front>
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