Detection of severe acute respiratory syndrome coronavirus in the brain : Potential role of the chemokine mig in pathogenesis
Identifieur interne : 005194 ( Main/Merge ); précédent : 005193; suivant : 005195Detection of severe acute respiratory syndrome coronavirus in the brain : Potential role of the chemokine mig in pathogenesis
Auteurs : JUN XU [République populaire de Chine] ; SHUQING ZHONG [République populaire de Chine] ; JINGHUA LIU [République populaire de Chine] ; LI LI [République populaire de Chine] ; YONG LI [République populaire de Chine] ; XINWEI WU [République populaire de Chine] ; ZHIJIE LI [République populaire de Chine] ; PENG DENG [République populaire de Chine] ; JINGQIANG ZHANG [République populaire de Chine] ; NANSHAN ZHONG [République populaire de Chine] ; YANQING DING [République populaire de Chine] ; YONG JIANG [République populaire de Chine]Source :
- Clinical infectious diseases [ 1058-4838 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Background. Previous studies have shown that common human coronavirus might be neurotropic, although it was first isolated as a pathogen of the respiratory tract. We noticed that a few patients with severe acute respiratory syndrome (SARS) experienced central nervous symptoms during the course of illness. In the present study, we isolated a SARS coronavirus strain from a brain tissue specimen obtained from a patient with SARS with significant central nervous symptoms. Methods. Using transmission electronic microscopy and nested reverse transcription-polymerase chain reaction, the causative pathogen was identified in cultures of a brain tissue specimen obtained from the patient with SARS. Histopathologic examination of the brain tissue was performed using the methods of immunohistochemistry analysis and double immunofluorescence staining. Fifteen cytokines and chemokines were detected in the blood of the patient with SARS by means of a bead-based multiassay system. Results. A fragment specific for SARS human coronavirus was amplified from cultures of the brain suspension, and transmission electronic microscopy revealed the presence of an enveloped virus morphologically compatible with a coronavirus isolated in the cultures. Pathologic examination of the brain tissue revealed necrosis of neuron cells and broad hyperplasia of gliocytes. Immunostaining demonstrated that monokine induced by interferon-γ (Mig) was expressed in gliocytes with the infiltration of CD68+ monocytes/macrophages and CD3+ T lymphocytes in the brain mesenchyme. Cytokine/chemokine assay revealed that levels of interferon-γ-inducible protein 10 and Mig in the blood were highly elevated, although the levels of other cytokines and chemokines were close to normal. Conclusions. This study provides direct evidence that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS.
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Functional Proteomics of Guangdong Province, Southern Medical University</s1><s3>CHN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Jingqiang Zhang" sort="Jingqiang Zhang" uniqKey="Jingqiang Zhang" last="Jingqiang Zhang">JINGQIANG ZHANG</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Electronic Microscope Center, Sun Yatsen University</s1><s2>Guangzhou</s2><s3>CHN</s3><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Nanshan Zhong" sort="Nanshan Zhong" uniqKey="Nanshan Zhong" last="Nanshan Zhong">NANSHAN ZHONG</name><affiliation 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sort="Yong Jiang" uniqKey="Yong Jiang" last="Yong Jiang">YONG JIANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</s1><s3>CHN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0000179</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 06-0000179 INIST</idno><idno type="RBID">Pascal:06-0000179</idno><idno type="wicri:Area/PascalFrancis/Corpus">000573</idno><idno type="wicri:Area/PascalFrancis/Curation">000417</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000674</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" 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ZHONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Southern Medical University</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Institute of Respiratory Diseases, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Jinghua Liu" sort="Jinghua Liu" uniqKey="Jinghua Liu" last="Jinghua Liu">JINGHUA LIU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</s1><s3>CHN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Li Li" sort="Li Li" uniqKey="Li Li" last="Li Li">LI LI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Southern Medical University</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Institute of Respiratory Diseases, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Yong Li" sort="Yong Li" uniqKey="Yong Li" last="Yong Li">YONG LI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Southern Medical University</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Institute of Respiratory Diseases, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Xinwei Wu" sort="Xinwei Wu" uniqKey="Xinwei Wu" last="Xinwei Wu">XINWEI WU</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Guangzhou Center for Diseases Control and Prevention, Sun Yatsen University</s1><s2>Guangzhou</s2><s3>CHN</s3><sZ>6 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhijie Li" sort="Zhijie Li" uniqKey="Zhijie Li" last="Zhijie Li">ZHIJIE LI</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</s1><s3>CHN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Peng Deng" sort="Peng Deng" uniqKey="Peng Deng" last="Peng Deng">PENG DENG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</s1><s3>CHN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Jingqiang Zhang" sort="Jingqiang Zhang" uniqKey="Jingqiang Zhang" last="Jingqiang Zhang">JINGQIANG ZHANG</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Electronic Microscope Center, Sun Yatsen University</s1><s2>Guangzhou</s2><s3>CHN</s3><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Nanshan Zhong" sort="Nanshan Zhong" uniqKey="Nanshan Zhong" last="Nanshan Zhong">NANSHAN ZHONG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Southern Medical University</s1><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Institute of Respiratory Diseases, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Yanqing Ding" sort="Yanqing Ding" uniqKey="Yanqing Ding" last="Yanqing Ding">YANQING DING</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</s1><s3>CHN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Yong Jiang" sort="Yong Jiang" uniqKey="Yong Jiang" last="Yong Jiang">YONG JIANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</s1><s3>CHN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Clinical infectious diseases</title><title level="j" type="abbreviated">Clin. infect. dis.</title><idno type="ISSN">1058-4838</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical infectious diseases</title><title level="j" type="abbreviated">Clin. infect. dis.</title><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain</term><term>Chemokine</term><term>Coronavirus</term><term>Encephalon</term><term>Pathogenesis</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Encéphale</term><term>Cerveau</term><term>Chimiokine</term><term>Coronavirus</term><term>Pathogénie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Previous studies have shown that common human coronavirus might be neurotropic, although it was first isolated as a pathogen of the respiratory tract. We noticed that a few patients with severe acute respiratory syndrome (SARS) experienced central nervous symptoms during the course of illness. In the present study, we isolated a SARS coronavirus strain from a brain tissue specimen obtained from a patient with SARS with significant central nervous symptoms. Methods. Using transmission electronic microscopy and nested reverse transcription-polymerase chain reaction, the causative pathogen was identified in cultures of a brain tissue specimen obtained from the patient with SARS. Histopathologic examination of the brain tissue was performed using the methods of immunohistochemistry analysis and double immunofluorescence staining. Fifteen cytokines and chemokines were detected in the blood of the patient with SARS by means of a bead-based multiassay system. Results. A fragment specific for SARS human coronavirus was amplified from cultures of the brain suspension, and transmission electronic microscopy revealed the presence of an enveloped virus morphologically compatible with a coronavirus isolated in the cultures. Pathologic examination of the brain tissue revealed necrosis of neuron cells and broad hyperplasia of gliocytes. Immunostaining demonstrated that monokine induced by interferon-γ (Mig) was expressed in gliocytes with the infiltration of CD68<sup>+</sup> monocytes/macrophages and CD3<sup>+</sup> T lymphocytes in the brain mesenchyme. Cytokine/chemokine assay revealed that levels of interferon-γ-inducible protein 10 and Mig in the blood were highly elevated, although the levels of other cytokines and chemokines were close to normal. Conclusions. This study provides direct evidence that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Jun Xu" sort="Jun Xu" uniqKey="Jun Xu" last="Jun Xu">JUN XU</name></noRegion><name sortKey="Jinghua Liu" sort="Jinghua Liu" uniqKey="Jinghua Liu" last="Jinghua Liu">JINGHUA LIU</name><name sortKey="Jingqiang Zhang" sort="Jingqiang Zhang" uniqKey="Jingqiang Zhang" last="Jingqiang Zhang">JINGQIANG ZHANG</name><name sortKey="Li Li" sort="Li Li" uniqKey="Li Li" last="Li Li">LI LI</name><name sortKey="Nanshan Zhong" sort="Nanshan Zhong" uniqKey="Nanshan Zhong" last="Nanshan Zhong">NANSHAN ZHONG</name><name sortKey="Peng Deng" sort="Peng Deng" uniqKey="Peng Deng" last="Peng Deng">PENG DENG</name><name sortKey="Shuqing Zhong" sort="Shuqing Zhong" uniqKey="Shuqing Zhong" last="Shuqing Zhong">SHUQING ZHONG</name><name sortKey="Xinwei Wu" sort="Xinwei Wu" uniqKey="Xinwei Wu" last="Xinwei Wu">XINWEI WU</name><name sortKey="Yanqing Ding" sort="Yanqing Ding" uniqKey="Yanqing Ding" last="Yanqing Ding">YANQING DING</name><name sortKey="Yong Jiang" sort="Yong Jiang" uniqKey="Yong Jiang" last="Yong Jiang">YONG JIANG</name><name sortKey="Yong Li" sort="Yong Li" uniqKey="Yong Li" last="Yong Li">YONG LI</name><name sortKey="Zhijie Li" sort="Zhijie Li" uniqKey="Zhijie Li" last="Zhijie Li">ZHIJIE LI</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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