SrasV1, Main, Merge, bibRecord, 004691

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

Identifieur interne : 004691 ( Main/Merge ); précédent : 004690; suivant : 004692

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

Auteurs : Christophe Biot [France] ; Wassim Daher [France] ; Natascha Chavain [France] ; Thierry Fandeur [France] ; Jamal Khalife [France] ; Daniel Dive [France] ; Erik De Clercq [Belgique]

Source :

Journal of medicinal chemistry : (Print) [ 0022-2623 ] ; 2006.

RBID : Pascal:06-0425480

Descripteurs français

Pascal (Inist)
- Synthèse chimique, Antipaludique, Antiviral, Activité biologique, Quinoléine dérivé, Aminoalcool, Alcool primaire, Plasmodium falciparum, Coronavirus, In vitro, Antiparasitaire, Antiprotozoaire, Métallocène, Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]), Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl), Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl), Ferrocène dérivé.

English descriptors

KwdEn :
- Aminoalcohol, Antimalarial, Antiprotozoal agent, Antiviral, Biological activity, Chemical synthesis, Coronavirus, In vitro, Metallocene, Parasiticide, Plasmodium falciparum, Primary alcohol, Quinoline derivatives.

Abstract

Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000464
to stream PascalFrancis, to step Curation: 000526
to stream PascalFrancis, to step Checkpoint: 000490

Links to Exploration step

Pascal:06-0425480

Le document en format XML

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<author><name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>UMR Uniuersité-INRA d'lmmunologie Parasitaire, Faculté des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont</s1>
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<author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminoalcohol</term>
<term>Antimalarial</term>
<term>Antiprotozoal agent</term>
<term>Antiviral</term>
<term>Biological activity</term>
<term>Chemical synthesis</term>
<term>Coronavirus</term>
<term>In vitro</term>
<term>Metallocene</term>
<term>Parasiticide</term>
<term>Plasmodium falciparum</term>
<term>Primary alcohol</term>
<term>Quinoline derivatives</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Synthèse chimique</term>
<term>Antipaludique</term>
<term>Antiviral</term>
<term>Activité biologique</term>
<term>Quinoléine dérivé</term>
<term>Aminoalcool</term>
<term>Alcool primaire</term>
<term>Plasmodium falciparum</term>
<term>Coronavirus</term>
<term>In vitro</term>
<term>Antiparasitaire</term>
<term>Antiprotozoaire</term>
<term>Métallocène</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl])</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl)</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl)</term>
<term>Ferrocène dérivé</term>
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<front><div type="abstract" xml:lang="en">Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</div>
</front>
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<tree><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
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<name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
<name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name>
<name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name>
<name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
</country>
<country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name>
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Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri