SrasV1, PascalFrancis, Corpus, bibRecord, 000464

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

Identifieur interne : 000464 ( PascalFrancis/Corpus ); précédent : 000463; suivant : 000465

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

Auteurs : Christophe Biot ; Wassim Daher ; Natascha Chavain ; Thierry Fandeur ; Jamal Khalife ; Daniel Dive ; Erik De Clercq

Source :

Journal of medicinal chemistry : (Print) [ 0022-2623 ] ; 2006.

RBID : Pascal:06-0425480

Descripteurs français

Pascal (Inist)
- Synthèse chimique, Antipaludique, Antiviral, Activité biologique, Quinoléine dérivé, Aminoalcool, Alcool primaire, Plasmodium falciparum, Coronavirus, In vitro, Antiparasitaire, Antiprotozoaire, Métallocène, Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]), Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl), Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl), Ferrocène dérivé.

English descriptors

KwdEn :
- Aminoalcohol, Antimalarial, Antiprotozoal agent, Antiviral, Biological activity, Chemical synthesis, Coronavirus, In vitro, Metallocene, Parasiticide, Plasmodium falciparum, Primary alcohol, Quinoline derivatives.

Abstract

Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 JMCMAR`
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A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities`
A11	`01`	`1`		`@1 BIOT (Christophe)`
A11	`02`	`1`		`@1 DAHER (Wassim)`
A11	`03`	`1`		`@1 CHAVAIN (Natascha)`
A11	`04`	`1`		`@1 FANDEUR (Thierry)`
A11	`05`	`1`		`@1 KHALIFE (Jamal)`
A11	`06`	`1`		`@1 DIVE (Daniel)`
A11	`07`	`1`		`@1 DE CLERCQ (Erik)`
A14	`01`			`@1 Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108 @2 59652, Villeneuve d' Ascq @3 FRA @Z 1 aut. @Z 3 aut.`
A14	`02`			`@1 Inserm, U547, Institut Pasteur, I rue du Pr Calmette, B.P. 245 @2 59019 Lille @3 FRA @Z 2 aut. @Z 5 aut. @Z 6 aut.`
A14	`03`			`@1 UMR Uniuersité-INRA d'lmmunologie Parasitaire, Faculté des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont @2 37200 Tours @3 FRA @Z 4 aut.`
A14	`04`			`@1 Rega Institute for Medical Research, K.U.Leuven @2 3000 Leuven @3 BEL @Z 7 aut.`
A20				`@1 2845-2849`
A21				`@1 2006`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 9165 @5 354000115413240230`
A44				`@0 0000 @1 © 2006 INIST-CNRS. All rights reserved.`
A45				`@0 34 ref.`
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A61				`@0 A`
A64	`01`	`1`		`@0 Journal of medicinal chemistry : (Print)`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.
C02	`01`	`X`		`@0 002B02S06`
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C03	`01`	`X`	`ENG`	`@0 Chemical synthesis @5 01`
C03	`01`	`X`	`SPA`	`@0 Síntesis química @5 01`
C03	`02`	`X`	`FRE`	`@0 Antipaludique @5 02`
C03	`02`	`X`	`ENG`	`@0 Antimalarial @5 02`
C03	`02`	`X`	`SPA`	`@0 Antipalúdico @5 02`
C03	`03`	`X`	`FRE`	`@0 Antiviral @5 03`
C03	`03`	`X`	`ENG`	`@0 Antiviral @5 03`
C03	`03`	`X`	`SPA`	`@0 Antiviral @5 03`
C03	`04`	`X`	`FRE`	`@0 Activité biologique @5 04`
C03	`04`	`X`	`ENG`	`@0 Biological activity @5 04`
C03	`04`	`X`	`SPA`	`@0 Actividad biológica @5 04`
C03	`05`	`X`	`FRE`	`@0 Quinoléine dérivé @2 FF @5 05`
C03	`05`	`X`	`ENG`	`@0 Quinoline derivatives @2 FF @5 05`
C03	`05`	`X`	`SPA`	`@0 Quinolina derivado @2 FF @5 05`
C03	`06`	`X`	`FRE`	`@0 Aminoalcool @5 08`
C03	`06`	`X`	`ENG`	`@0 Aminoalcohol @5 08`
C03	`06`	`X`	`SPA`	`@0 Aminoalcohol @5 08`
C03	`07`	`X`	`FRE`	`@0 Alcool primaire @5 09`
C03	`07`	`X`	`ENG`	`@0 Primary alcohol @5 09`
C03	`07`	`X`	`SPA`	`@0 Alcohol primario @5 09`
C03	`08`	`X`	`FRE`	`@0 Plasmodium falciparum @2 NS @5 10`
C03	`08`	`X`	`ENG`	`@0 Plasmodium falciparum @2 NS @5 10`
C03	`08`	`X`	`SPA`	`@0 Plasmodium falciparum @2 NS @5 10`
C03	`09`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 11`
C03	`09`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 11`
C03	`09`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 11`
C03	`10`	`X`	`FRE`	`@0 In vitro @5 12`
C03	`10`	`X`	`ENG`	`@0 In vitro @5 12`
C03	`10`	`X`	`SPA`	`@0 In vitro @5 12`
C03	`11`	`X`	`FRE`	`@0 Antiparasitaire @5 32`
C03	`11`	`X`	`ENG`	`@0 Parasiticide @5 32`
C03	`11`	`X`	`SPA`	`@0 Antiparasitario @5 32`
C03	`12`	`X`	`FRE`	`@0 Antiprotozoaire @5 33`
C03	`12`	`X`	`ENG`	`@0 Antiprotozoal agent @5 33`
C03	`12`	`X`	`SPA`	`@0 Antiprotozoario @5 33`
C03	`13`	`X`	`FRE`	`@0 Métallocène @5 34`
C03	`13`	`X`	`ENG`	`@0 Metallocene @5 34`
C03	`13`	`X`	`SPA`	`@0 Metaloceno @5 34`
C03	`14`	`X`	`FRE`	`@0 Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]) @2 NK @4 INC @5 76`
C03	`15`	`X`	`FRE`	`@0 Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl) @2 NK @4 INC @5 77`
C03	`16`	`X`	`FRE`	`@0 Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl) @2 NK @4 INC @5 78`
C03	`17`	`X`	`FRE`	`@0 Ferrocène dérivé @2 NK @4 INC @5 79`
C07	`01`	`X`	`FRE`	`@0 Chlore Composé organique @2 NC @2 FX @2 NA @5 06`
C07	`01`	`X`	`ENG`	`@0 Chlorine Organic compounds @2 NC @2 FX @2 NA @5 06`
C07	`01`	`X`	`SPA`	`@0 Cloro Compuesto orgánico @2 NC @2 FX @2 NA @5 06`
C07	`02`	`X`	`FRE`	`@0 Fer Composé organique @2 NC @2 NA @5 07`
C07	`02`	`X`	`ENG`	`@0 Iron Organic compounds @2 NC @2 NA @5 07`
C07	`02`	`X`	`SPA`	`@0 Hierro Compuesto orgánico @2 NC @2 NA @5 07`
C07	`03`	`X`	`FRE`	`@0 Apicomplexa @2 NS`
C07	`03`	`X`	`ENG`	`@0 Apicomplexa @2 NS`
C07	`03`	`X`	`SPA`	`@0 Apicomplexa @2 NS`
C07	`04`	`X`	`FRE`	`@0 Protozoa @2 NS`
C07	`04`	`X`	`ENG`	`@0 Protozoa @2 NS`
C07	`04`	`X`	`SPA`	`@0 Protozoa @2 NS`
C07	`05`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`05`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`05`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`06`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`06`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`06`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`07`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`07`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`07`	`X`	`SPA`	`@0 Virus @2 NW`
N21				`@1 282`

Format Inist (serveur)

NO :	PASCAL 06-0425480 INIST
ET :	Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities
AU :	BIOT (Christophe); DAHER (Wassim); CHAVAIN (Natascha); FANDEUR (Thierry); KHALIFE (Jamal); DIVE (Daniel); DE CLERCQ (Erik)
AF :	Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108/59652, Villeneuve d' Ascq/France (1 aut., 3 aut.); Inserm, U547, Institut Pasteur, I rue du Pr Calmette, B.P. 245/59019 Lille/France (2 aut., 5 aut., 6 aut.); UMR Uniuersité-INRA d'lmmunologie Parasitaire, Faculté des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont/37200 Tours/France (4 aut.); Rega Institute for Medical Research, K.U.Leuven/3000 Leuven/Belgique (7 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Journal of medicinal chemistry : (Print); ISSN 0022-2623; Coden JMCMAR; Etats-Unis; Da. 2006; Vol. 49; No. 9; Pp. 2845-2849; Bibl. 34 ref.
LA :	Anglais
EA :	Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.
CC :	002B02S06; 002B02S05
FD :	Synthèse chimique; Antipaludique; Antiviral; Activité biologique; Quinoléine dérivé; Aminoalcool; Alcool primaire; Plasmodium falciparum; Coronavirus; In vitro; Antiparasitaire; Antiprotozoaire; Métallocène; Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]); Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl); Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl); Ferrocène dérivé
FG :	Chlore Composé organique; Fer Composé organique; Apicomplexa; Protozoa; Coronaviridae; Nidovirales; Virus
ED :	Chemical synthesis; Antimalarial; Antiviral; Biological activity; Quinoline derivatives; Aminoalcohol; Primary alcohol; Plasmodium falciparum; Coronavirus; In vitro; Parasiticide; Antiprotozoal agent; Metallocene
EG :	Chlorine Organic compounds; Iron Organic compounds; Apicomplexa; Protozoa; Coronaviridae; Nidovirales; Virus
SD :	Síntesis química; Antipalúdico; Antiviral; Actividad biológica; Quinolina derivado; Aminoalcohol; Alcohol primario; Plasmodium falciparum; Coronavirus; In vitro; Antiparasitario; Antiprotozoario; Metaloceno
LO :	INIST-9165.354000115413240230
ID :	06-0425480

Links to Exploration step

Pascal:06-0425480

Le document en format XML

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<series><title level="j" type="main">Journal of medicinal chemistry : (Print)</title>
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<term>Biological activity</term>
<term>Chemical synthesis</term>
<term>Coronavirus</term>
<term>In vitro</term>
<term>Metallocene</term>
<term>Parasiticide</term>
<term>Plasmodium falciparum</term>
<term>Primary alcohol</term>
<term>Quinoline derivatives</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Synthèse chimique</term>
<term>Antipaludique</term>
<term>Antiviral</term>
<term>Activité biologique</term>
<term>Quinoléine dérivé</term>
<term>Aminoalcool</term>
<term>Alcool primaire</term>
<term>Plasmodium falciparum</term>
<term>Coronavirus</term>
<term>In vitro</term>
<term>Antiparasitaire</term>
<term>Antiprotozoaire</term>
<term>Métallocène</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl])</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl)</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl)</term>
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<front><div type="abstract" xml:lang="en">Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-2623</s0>
</fA01>
<fA02 i1="01"><s0>JMCMAR</s0>
</fA02>
<fA03 i2="1"><s0>J. med. chem. : (Print)</s0>
</fA03>
<fA05><s2>49</s2>
</fA05>
<fA06><s2>9</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>BIOT (Christophe)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>DAHER (Wassim)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>CHAVAIN (Natascha)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>FANDEUR (Thierry)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>KHALIFE (Jamal)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>DIVE (Daniel)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>DE CLERCQ (Erik)</s1>
</fA11>
<fA14 i1="01"><s1>Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108</s1>
<s2>59652, Villeneuve d' Ascq</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Inserm, U547, Institut Pasteur, I rue du Pr Calmette, B.P. 245</s1>
<s2>59019 Lille</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>UMR Uniuersité-INRA d'lmmunologie Parasitaire, Faculté des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont</s1>
<s2>37200 Tours</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Rega Institute for Medical Research, K.U.Leuven</s1>
<s2>3000 Leuven</s2>
<s3>BEL</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>2845-2849</s1>
</fA20>
<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>9165</s2>
<s5>354000115413240230</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>34 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0425480</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of medicinal chemistry : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S06</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B02S05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Synthèse chimique</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Chemical synthesis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Síntesis química</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Antipaludique</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Antimalarial</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Antipalúdico</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Activité biologique</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Biological activity</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Actividad biológica</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Quinoléine dérivé</s0>
<s2>FF</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Quinoline derivatives</s0>
<s2>FF</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Quinolina derivado</s0>
<s2>FF</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Aminoalcool</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Aminoalcohol</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Aminoalcohol</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Alcool primaire</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Primary alcohol</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Alcohol primario</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Plasmodium falciparum</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Plasmodium falciparum</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Plasmodium falciparum</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>In vitro</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>In vitro</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>In vitro</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Antiparasitaire</s0>
<s5>32</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Parasiticide</s0>
<s5>32</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Antiparasitario</s0>
<s5>32</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Antiprotozoaire</s0>
<s5>33</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Antiprotozoal agent</s0>
<s5>33</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Antiprotozoario</s0>
<s5>33</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Métallocène</s0>
<s5>34</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Metallocene</s0>
<s5>34</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Metaloceno</s0>
<s5>34</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl])</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl)</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>77</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl)</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Ferrocène dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>79</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Chlore Composé organique</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>06</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Chlorine Organic compounds</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>06</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Cloro Compuesto orgánico</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>06</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Fer Composé organique</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>07</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Iron Organic compounds</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>07</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Hierro Compuesto orgánico</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>07</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>282</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 06-0425480 INIST</NO>
<ET>Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities</ET>
<AU>BIOT (Christophe); DAHER (Wassim); CHAVAIN (Natascha); FANDEUR (Thierry); KHALIFE (Jamal); DIVE (Daniel); DE CLERCQ (Erik)</AU>
<AF>Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108/59652, Villeneuve d' Ascq/France (1 aut., 3 aut.); Inserm, U547, Institut Pasteur, I rue du Pr Calmette, B.P. 245/59019 Lille/France (2 aut., 5 aut., 6 aut.); UMR Uniuersité-INRA d'lmmunologie Parasitaire, Faculté des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont/37200 Tours/France (4 aut.); Rega Institute for Medical Research, K.U.Leuven/3000 Leuven/Belgique (7 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Journal of medicinal chemistry : (Print); ISSN 0022-2623; Coden JMCMAR; Etats-Unis; Da. 2006; Vol. 49; No. 9; Pp. 2845-2849; Bibl. 34 ref.</SO>
<LA>Anglais</LA>
<EA>Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</EA>
<CC>002B02S06; 002B02S05</CC>
<FD>Synthèse chimique; Antipaludique; Antiviral; Activité biologique; Quinoléine dérivé; Aminoalcool; Alcool primaire; Plasmodium falciparum; Coronavirus; In vitro; Antiparasitaire; Antiprotozoaire; Métallocène; Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]); Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl); Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl); Ferrocène dérivé</FD>
<FG>Chlore Composé organique; Fer Composé organique; Apicomplexa; Protozoa; Coronaviridae; Nidovirales; Virus</FG>
<ED>Chemical synthesis; Antimalarial; Antiviral; Biological activity; Quinoline derivatives; Aminoalcohol; Primary alcohol; Plasmodium falciparum; Coronavirus; In vitro; Parasiticide; Antiprotozoal agent; Metallocene</ED>
<EG>Chlorine Organic compounds; Iron Organic compounds; Apicomplexa; Protozoa; Coronaviridae; Nidovirales; Virus</EG>
<SD>Síntesis química; Antipalúdico; Antiviral; Actividad biológica; Quinolina derivado; Aminoalcohol; Alcohol primario; Plasmodium falciparum; Coronavirus; In vitro; Antiparasitario; Antiprotozoario; Metaloceno</SD>
<LO>INIST-9165.354000115413240230</LO>
<ID>06-0425480</ID>
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Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities

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