Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities
Identifieur interne : 000526 ( PascalFrancis/Curation ); précédent : 000525; suivant : 000527Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities
Auteurs : Christophe Biot [France] ; Wassim Daher [France] ; Natascha Chavain [France] ; Thierry Fandeur [France] ; Jamal Khalife [France] ; Daniel Dive [France] ; Erik De Clercq [Belgique]Source :
- Journal of medicinal chemistry : (Print) [ 0022-2623 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Synthèse chimique, Antipaludique, Antiviral, Activité biologique, Quinoléine dérivé, Aminoalcool, Alcool primaire, Plasmodium falciparum, Coronavirus, In vitro, Antiparasitaire, Antiprotozoaire, Métallocène, Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]), Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl), Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl), Ferrocène dérivé.
English descriptors
- KwdEn :
Abstract
Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.
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<front><div type="abstract" xml:lang="en">Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</div>
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<s5>77</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl)</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Ferrocène dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>79</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Chlore Composé organique</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>06</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Chlorine Organic compounds</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>06</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Cloro Compuesto orgánico</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>06</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Fer Composé organique</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>07</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Iron Organic compounds</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>07</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Hierro Compuesto orgánico</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>07</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Apicomplexa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Protozoa</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>282</s1>
</fN21>
</pA>
</standard>
</inist>
</record>
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