Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication
Identifieur interne : 003458 ( Main/Exploration ); précédent : 003457; suivant : 003459Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication
Auteurs : Chung-Jen Chen [Taïwan] ; Martin Michaelis [Allemagne] ; Hseng-Kuang Hsu [Taïwan] ; Chin-Chuan Tsai [Taïwan] ; Kunder D. Yang [Taïwan] ; Yang-Chang Wu [Taïwan] ; Jindrich Jr Cinatl [Allemagne] ; Hans Wilhelm Doerr [Allemagne]Source :
- Journal of ethnopharmacology [ 0378-8741 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (isolement et purification), Antiviraux (pharmacologie), Cedrela (), Cellules Vero, Extraits de plantes (pharmacologie), Feuilles de plante, Médecine traditionnelle d'Asie orientale, Médicaments issus de plantes chinoises (), Médicaments issus de plantes chinoises (pharmacologie), Réplication virale (), Virus du SRAS ().
- MESH :
- isolement et purification : Antiviraux.
- pharmacologie : Antiviraux, Extraits de plantes, Médicaments issus de plantes chinoises.
- Pascal (Inist)
- Animaux, Cedrela, Cellules Vero, Feuille végétal, Extrait, Feuilles de plante, Médecine traditionnelle d'Asie orientale, Médicaments issus de plantes chinoises, Réplication virale, Virus du SRAS, Virus syndrome respiratoire aigu sévère, Réplication, Antiviral, Plante médicinale, Pharmacognosie, Médecine Kampo, Origine végétale, Meliaceae, Médecine traditionnelle, Chine, Toona sinensis, Médecine traditionnelle chinoise.
- Wicri :
- topic : Plante médicinale.
English descriptors
- KwdEn :
- Animals, Antiviral, Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Cedrela (chemistry), China, Chlorocebus aethiops, Drugs, Chinese Herbal (chemistry), Drugs, Chinese Herbal (pharmacology), Extract, Folk medicine, Kampo medecine, Medicinal plant, Medicine, East Asian Traditional, Meliaceae, Pharmacognosy, Plant Extracts (pharmacology), Plant Leaves, Plant leaf, Plant origin, Replication, SARS Virus (drug effects), Severe acute respiratory syndrome virus, Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , chemistry : Drugs, Chinese Herbal.
- chemical , isolation & purification : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents, Drugs, Chinese Herbal, Plant Extracts.
- chemistry : Cedrela.
- drug effects : SARS Virus, Virus Replication.
- Animals, Chlorocebus aethiops, Medicine, East Asian Traditional, Plant Leaves, Vero Cells.
Abstract
Aim of the study: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV. Materials and Methods: Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro. Results: Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12∼17. Conclusion: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.
Affiliations:
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Yang</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Divhion of Pediatric Immunology and Allergy, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine</s1><s2>Kaohsiung</s2><s3>TWN</s3><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>School of Medicine, Chang Gung University College of Medicine</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taoyuan</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Graduate Institute of Natural Products, Kaohsiung Medical University</s1><s2>Kaohsiung</s2><s3>TWN</s3><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Cinatl, Jindrich Jr" sort="Cinatl, Jindrich Jr" uniqKey="Cinatl J" first="Jindrich Jr" last="Cinatl">Jindrich Jr Cinatl</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1><s2>Frankfurt Am Mein</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Frankfurt Am Mein</wicri:noRegion><wicri:noRegion>Frankfurt University</wicri:noRegion><wicri:noRegion>Frankfurt Am Mein</wicri:noRegion></affiliation></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1><s2>Frankfurt Am Mein</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 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uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine</s1><s2>Kaohsiung</s2><s3>TWN</s3><sZ>1 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Chinese Medicine, Chang Gung University College of Medicine</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taoyuan</wicri:noRegion></affiliation></author><author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1><s2>Frankfurt Am Mein</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Frankfurt Am Mein</wicri:noRegion><wicri:noRegion>Frankfurt University</wicri:noRegion><wicri:noRegion>Frankfurt Am Mein</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Physiology, College of Medicine, Kaohsiung Medical University</s1><s2>Kaohsiung</s2><s3>TWN</s3><sZ>3 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Chinese Medicine, E-DA Hospital, I-Shou University</s1><s2>Kaohsiung County</s2><s3>TWN</s3><sZ>4 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Kaohsiung County</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Divhion of Pediatric Immunology and Allergy, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine</s1><s2>Kaohsiung</s2><s3>TWN</s3><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>School of Medicine, Chang Gung University College of Medicine</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>5 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taoyuan</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Graduate Institute of Natural Products, Kaohsiung Medical University</s1><s2>Kaohsiung</s2><s3>TWN</s3><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Cinatl, Jindrich Jr" sort="Cinatl, Jindrich Jr" uniqKey="Cinatl J" first="Jindrich Jr" last="Cinatl">Jindrich Jr Cinatl</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1><s2>Frankfurt Am Mein</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Frankfurt Am Mein</wicri:noRegion><wicri:noRegion>Frankfurt University</wicri:noRegion><wicri:noRegion>Frankfurt Am Mein</wicri:noRegion></affiliation></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1><s2>Frankfurt Am Mein</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Frankfurt Am Mein</wicri:noRegion><wicri:noRegion>Frankfurt University</wicri:noRegion><wicri:noRegion>Frankfurt Am Mein</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of ethnopharmacology</title><title level="j" type="abbreviated">J. ethnopharmacol.</title><idno type="ISSN">0378-8741</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of ethnopharmacology</title><title level="j" type="abbreviated">J. ethnopharmacol.</title><idno type="ISSN">0378-8741</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral</term><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Cedrela (chemistry)</term><term>China</term><term>Chlorocebus aethiops</term><term>Drugs, Chinese Herbal (chemistry)</term><term>Drugs, Chinese Herbal (pharmacology)</term><term>Extract</term><term>Folk medicine</term><term>Kampo medecine</term><term>Medicinal plant</term><term>Medicine, East Asian Traditional</term><term>Meliaceae</term><term>Pharmacognosy</term><term>Plant Extracts (pharmacology)</term><term>Plant Leaves</term><term>Plant leaf</term><term>Plant origin</term><term>Replication</term><term>SARS Virus (drug effects)</term><term>Severe acute respiratory syndrome virus</term><term>Vero Cells</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Cedrela ()</term><term>Cellules Vero</term><term>Extraits de plantes (pharmacologie)</term><term>Feuilles de plante</term><term>Médecine traditionnelle d'Asie orientale</term><term>Médicaments issus de plantes chinoises ()</term><term>Médicaments issus de plantes chinoises (pharmacologie)</term><term>Réplication virale ()</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Drugs, Chinese Herbal</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Cedrela</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Extraits de plantes</term><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Medicine, East Asian Traditional</term><term>Plant Leaves</term><term>Vero Cells</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Cedrela</term><term>Cellules Vero</term><term>Feuille végétal</term><term>Extrait</term><term>Feuilles de plante</term><term>Médecine traditionnelle d'Asie orientale</term><term>Médicaments issus de plantes chinoises</term><term>Réplication virale</term><term>Virus du SRAS</term><term>Virus syndrome respiratoire aigu sévère</term><term>Réplication</term><term>Antiviral</term><term>Plante médicinale</term><term>Pharmacognosie</term><term>Médecine Kampo</term><term>Origine végétale</term><term>Meliaceae</term><term>Médecine traditionnelle</term><term>Chine</term><term>Toona sinensis</term><term>Médecine traditionnelle chinoise</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plante médicinale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aim of the study: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV. Materials and Methods: Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro. Results: Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12∼17. Conclusion: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name></noRegion><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name><name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name><name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name><name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name><name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name></country><country name="Allemagne"><noRegion><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name></noRegion><name sortKey="Cinatl, Jindrich Jr" sort="Cinatl, Jindrich Jr" uniqKey="Cinatl J" first="Jindrich Jr" last="Cinatl">Jindrich Jr Cinatl</name><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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