Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication.
Identifieur interne : 001D41 ( Ncbi/Merge ); précédent : 001D40; suivant : 001D42Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication.
Auteurs : Chung-Jen Chen [Taïwan] ; Martin Michaelis ; Hseng-Kuang Hsu ; Chin-Chuan Tsai ; Kunder D. Yang ; Yang-Chang Wu ; Jindrich Cinatl ; Hans Wilhelm DoerrSource :
- Journal of ethnopharmacology [ 0378-8741 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (isolement et purification), Antiviraux (pharmacologie), Cedrela (), Cellules Vero, Extraits de plantes (pharmacologie), Feuilles de plante, Médecine traditionnelle d'Asie orientale, Médicaments issus de plantes chinoises (), Médicaments issus de plantes chinoises (pharmacologie), Réplication virale (), Virus du SRAS ().
- MESH :
- isolement et purification : Antiviraux.
- pharmacologie : Antiviraux, Extraits de plantes, Médicaments issus de plantes chinoises.
- Animaux, Cedrela, Cellules Vero, Feuilles de plante, Médecine traditionnelle d'Asie orientale, Médicaments issus de plantes chinoises, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Cedrela (chemistry), Chlorocebus aethiops, Drugs, Chinese Herbal (chemistry), Drugs, Chinese Herbal (pharmacology), Medicine, East Asian Traditional, Plant Extracts (pharmacology), Plant Leaves, SARS Virus (drug effects), Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , chemistry : Drugs, Chinese Herbal.
- chemical , isolation & purification : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents, Drugs, Chinese Herbal, Plant Extracts.
- chemistry : Cedrela.
- drug effects : SARS Virus, Virus Replication.
- Animals, Chlorocebus aethiops, Medicine, East Asian Traditional, Plant Leaves, Vero Cells.
Abstract
Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV.
DOI: 10.1016/j.jep.2008.07.048
PubMed: 18762235
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pubmed:18762235Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication.</title><author><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. chungjen@adm.cgmh.org.tw</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name></author><author><name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name></author><author><name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name></author><author><name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D" last="Yang">Kunder D. Yang</name></author><author><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18762235</idno><idno type="pmid">18762235</idno><idno type="doi">10.1016/j.jep.2008.07.048</idno><idno type="wicri:Area/PubMed/Corpus">001A72</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A72</idno><idno type="wicri:Area/PubMed/Curation">001A72</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A72</idno><idno type="wicri:Area/PubMed/Checkpoint">001978</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001978</idno><idno type="wicri:Area/Ncbi/Merge">001D41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication.</title><author><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. chungjen@adm.cgmh.org.tw</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name></author><author><name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name></author><author><name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name></author><author><name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D" last="Yang">Kunder D. Yang</name></author><author><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name></author><author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="ISSN">0378-8741</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Cedrela (chemistry)</term><term>Chlorocebus aethiops</term><term>Drugs, Chinese Herbal (chemistry)</term><term>Drugs, Chinese Herbal (pharmacology)</term><term>Medicine, East Asian Traditional</term><term>Plant Extracts (pharmacology)</term><term>Plant Leaves</term><term>SARS Virus (drug effects)</term><term>Vero Cells</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Cedrela ()</term><term>Cellules Vero</term><term>Extraits de plantes (pharmacologie)</term><term>Feuilles de plante</term><term>Médecine traditionnelle d'Asie orientale</term><term>Médicaments issus de plantes chinoises ()</term><term>Médicaments issus de plantes chinoises (pharmacologie)</term><term>Réplication virale ()</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Drugs, Chinese Herbal</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Cedrela</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Extraits de plantes</term><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Medicine, East Asian Traditional</term><term>Plant Leaves</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cedrela</term><term>Cellules Vero</term><term>Feuilles de plante</term><term>Médecine traditionnelle d'Asie orientale</term><term>Médicaments issus de plantes chinoises</term><term>Réplication virale</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18762235</PMID><DateCompleted><Year>2009</Year><Month>01</Month><Day>27</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0378-8741</ISSN><JournalIssue CitedMedium="Print"><Volume>120</Volume><Issue>1</Issue><PubDate><Year>2008</Year><Month>Oct</Month><Day>30</Day></PubDate></JournalIssue><Title>Journal of ethnopharmacology</Title><ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation></Journal><ArticleTitle>Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication.</ArticleTitle><Pagination><MedlinePgn>108-11</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2008.07.048</ELocationID><Abstract><AbstractText Label="AIM OF THE STUDY" NlmCategory="OBJECTIVE">Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12 approximately 17.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Chung-Jen</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. chungjen@adm.cgmh.org.tw</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michaelis</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hsu</LastName><ForeName>Hseng-Kuang</ForeName><Initials>HK</Initials></Author><Author ValidYN="Y"><LastName>Tsai</LastName><ForeName>Chin-Chuan</ForeName><Initials>CC</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Kunder D</ForeName><Initials>KD</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Yang-Chang</ForeName><Initials>YC</Initials></Author><Author ValidYN="Y"><LastName>Cinatl</LastName><ForeName>Jindrich</ForeName><Initials>J</Initials><Suffix>Jr</Suffix></Author><Author ValidYN="Y"><LastName>Doerr</LastName><ForeName>Hans Wilhelm</ForeName><Initials>HW</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>08</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>J Ethnopharmacol</MedlineTA><NlmUniqueID>7903310</NlmUniqueID><ISSNLinking>0378-8741</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D031587" MajorTopicYN="N">Cedrela</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004365" MajorTopicYN="N">Drugs, Chinese Herbal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008518" MajorTopicYN="N">Medicine, East Asian Traditional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018515" MajorTopicYN="N">Plant Leaves</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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last="Doerr">Hans Wilhelm Doerr</name><name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name><name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name><name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D" last="Yang">Kunder D. Yang</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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