SrasV1, PascalFrancis, Checkpoint, bibRecord, 000235

Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

Identifieur interne : 000235 ( PascalFrancis/Checkpoint ); précédent : 000234; suivant : 000236

Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

Auteurs : Chung-Jen Chen [Taïwan] ; Martin Michaelis [Allemagne] ; Hseng-Kuang Hsu [Taïwan] ; Chin-Chuan Tsai [Taïwan] ; Kunder D. Yang [Taïwan] ; Yang-Chang Wu [Taïwan] ; Jindrich Jr Cinatl [Allemagne] ; Hans Wilhelm Doerr [Allemagne]

Source :

Journal of ethnopharmacology [ 0378-8741 ] ; 2008.

RBID : Pascal:08-0536530

Descripteurs français

Pascal (Inist)
- Feuille végétal, Extrait, Virus syndrome respiratoire aigu sévère, Réplication, Antiviral, Plante médicinale, Pharmacognosie, Médecine Kampo, Origine végétale, Meliaceae, Médecine traditionnelle, Chine, Toona sinensis, Médecine traditionnelle chinoise.
Wicri :
- topic : Plante médicinale.

English descriptors

KwdEn :
- Antiviral, China, Extract, Folk medicine, Kampo medecine, Medicinal plant, Meliaceae, Pharmacognosy, Plant leaf, Plant origin, Replication, Severe acute respiratory syndrome virus.

Abstract

Aim of the study: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV. Materials and Methods: Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro. Results: Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12∼17. Conclusion: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.

Affiliations:

Allemagne, Taïwan

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<front><div type="abstract" xml:lang="en">Aim of the study: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV. Materials and Methods: Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro. Results: Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12∼17. Conclusion: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.</div>
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<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Extracto</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Réplication</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Replication</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Replicación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Plante médicinale</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Medicinal plant</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Planta medicinal</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Pharmacognosie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Pharmacognosy</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Farmacognosia</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Médecine Kampo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Kampo medecine</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Medicina Kampo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Origine végétale</s0>
<s5>23</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Plant origin</s0>
<s5>23</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Origen vegetal</s0>
<s5>23</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Meliaceae</s0>
<s2>NS</s2>
<s5>24</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Meliaceae</s0>
<s2>NS</s2>
<s5>24</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Meliaceae</s0>
<s2>NS</s2>
<s5>24</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Médecine traditionnelle</s0>
<s5>25</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Folk medicine</s0>
<s5>25</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Medicina tradicional</s0>
<s5>25</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Chine</s0>
<s2>NG</s2>
<s5>26</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>China</s0>
<s2>NG</s2>
<s5>26</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>China</s0>
<s2>NG</s2>
<s5>26</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Toona sinensis</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Médecine traditionnelle chinoise</s0>
<s4>INC</s4>
<s5>87</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fN21><s1>350</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Allemagne</li>
<li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name>
</noRegion>
<name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name>
<name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name>
<name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name>
<name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name>
<name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name>
<name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name>
</noRegion>
<name sortKey="Cinatl, Jindrich Jr" sort="Cinatl, Jindrich Jr" uniqKey="Cinatl J" first="Jindrich Jr" last="Cinatl">Jindrich Jr Cinatl</name>
<name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication
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Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

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