Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication
Identifieur interne : 003561 ( Main/Merge ); précédent : 003560; suivant : 003562Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication
Auteurs : Chung-Jen Chen [Taïwan] ; Martin Michaelis [Allemagne] ; Hseng-Kuang Hsu [Taïwan] ; Chin-Chuan Tsai [Taïwan] ; Kunder D. Yang [Taïwan] ; Yang-Chang Wu [Taïwan] ; Jindrich Jr Cinatl [Allemagne] ; Hans Wilhelm Doerr [Allemagne]Source :
- Journal of ethnopharmacology [ 0378-8741 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Plante médicinale.
English descriptors
- KwdEn :
Abstract
Aim of the study: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV. Materials and Methods: Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro. Results: Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12∼17. Conclusion: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000243
- to stream PascalFrancis, to step Curation: 000745
- to stream PascalFrancis, to step Checkpoint: 000235
Links to Exploration step
Pascal:08-0536530Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication</title>
<author><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine</s1>
<s2>Kaohsiung</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Chinese Medicine, Chang Gung University College of Medicine</s1>
<s2>Taoyuan</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1>
<s2>Frankfurt Am Mein</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
<wicri:noRegion>Frankfurt University</wicri:noRegion>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Physiology, College of Medicine, Kaohsiung Medical University</s1>
<s2>Kaohsiung</s2>
<s3>TWN</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Chinese Medicine, E-DA Hospital, I-Shou University</s1>
<s2>Kaohsiung County</s2>
<s3>TWN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung County</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Divhion of Pediatric Immunology and Allergy, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine</s1>
<s2>Kaohsiung</s2>
<s3>TWN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>School of Medicine, Chang Gung University College of Medicine</s1>
<s2>Taoyuan</s2>
<s3>TWN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Graduate Institute of Natural Products, Kaohsiung Medical University</s1>
<s2>Kaohsiung</s2>
<s3>TWN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cinatl, Jindrich Jr" sort="Cinatl, Jindrich Jr" uniqKey="Cinatl J" first="Jindrich Jr" last="Cinatl">Jindrich Jr Cinatl</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1>
<s2>Frankfurt Am Mein</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
<wicri:noRegion>Frankfurt University</wicri:noRegion>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1>
<s2>Frankfurt Am Mein</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
<wicri:noRegion>Frankfurt University</wicri:noRegion>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0536530</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0536530 INIST</idno>
<idno type="RBID">Pascal:08-0536530</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000243</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000745</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000235</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000235</idno>
<idno type="wicri:doubleKey">0378-8741:2008:Chen C:toona:sinensis:roem</idno>
<idno type="wicri:Area/Main/Merge">003561</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication</title>
<author><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine</s1>
<s2>Kaohsiung</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Chinese Medicine, Chang Gung University College of Medicine</s1>
<s2>Taoyuan</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1>
<s2>Frankfurt Am Mein</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
<wicri:noRegion>Frankfurt University</wicri:noRegion>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Physiology, College of Medicine, Kaohsiung Medical University</s1>
<s2>Kaohsiung</s2>
<s3>TWN</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Chinese Medicine, E-DA Hospital, I-Shou University</s1>
<s2>Kaohsiung County</s2>
<s3>TWN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung County</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Divhion of Pediatric Immunology and Allergy, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine</s1>
<s2>Kaohsiung</s2>
<s3>TWN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>School of Medicine, Chang Gung University College of Medicine</s1>
<s2>Taoyuan</s2>
<s3>TWN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Graduate Institute of Natural Products, Kaohsiung Medical University</s1>
<s2>Kaohsiung</s2>
<s3>TWN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cinatl, Jindrich Jr" sort="Cinatl, Jindrich Jr" uniqKey="Cinatl J" first="Jindrich Jr" last="Cinatl">Jindrich Jr Cinatl</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1>
<s2>Frankfurt Am Mein</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
<wicri:noRegion>Frankfurt University</wicri:noRegion>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Medical Virology, Frankfurt University</s1>
<s2>Frankfurt Am Mein</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
<wicri:noRegion>Frankfurt University</wicri:noRegion>
<wicri:noRegion>Frankfurt Am Mein</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of ethnopharmacology</title>
<title level="j" type="abbreviated">J. ethnopharmacol.</title>
<idno type="ISSN">0378-8741</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of ethnopharmacology</title>
<title level="j" type="abbreviated">J. ethnopharmacol.</title>
<idno type="ISSN">0378-8741</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term>
<term>China</term>
<term>Extract</term>
<term>Folk medicine</term>
<term>Kampo medecine</term>
<term>Medicinal plant</term>
<term>Meliaceae</term>
<term>Pharmacognosy</term>
<term>Plant leaf</term>
<term>Plant origin</term>
<term>Replication</term>
<term>Severe acute respiratory syndrome virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Feuille végétal</term>
<term>Extrait</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Réplication</term>
<term>Antiviral</term>
<term>Plante médicinale</term>
<term>Pharmacognosie</term>
<term>Médecine Kampo</term>
<term>Origine végétale</term>
<term>Meliaceae</term>
<term>Médecine traditionnelle</term>
<term>Chine</term>
<term>Toona sinensis</term>
<term>Médecine traditionnelle chinoise</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plante médicinale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Aim of the study: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV. Materials and Methods: Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro. Results: Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12∼17. Conclusion: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name>
</noRegion>
<name sortKey="Chen, Chung Jen" sort="Chen, Chung Jen" uniqKey="Chen C" first="Chung-Jen" last="Chen">Chung-Jen Chen</name>
<name sortKey="Hsu, Hseng Kuang" sort="Hsu, Hseng Kuang" uniqKey="Hsu H" first="Hseng-Kuang" last="Hsu">Hseng-Kuang Hsu</name>
<name sortKey="Tsai, Chin Chuan" sort="Tsai, Chin Chuan" uniqKey="Tsai C" first="Chin-Chuan" last="Tsai">Chin-Chuan Tsai</name>
<name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name>
<name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name>
<name sortKey="Yang, Kunder D" sort="Yang, Kunder D" uniqKey="Yang K" first="Kunder D." last="Yang">Kunder D. Yang</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name>
</noRegion>
<name sortKey="Cinatl, Jindrich Jr" sort="Cinatl, Jindrich Jr" uniqKey="Cinatl J" first="Jindrich Jr" last="Cinatl">Jindrich Jr Cinatl</name>
<name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003561 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003561 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Merge |type= RBID |clé= Pascal:08-0536530 |texte= Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |