Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003
Identifieur interne : 004457 ( Main/Exploration ); précédent : 004456; suivant : 004458Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003
Auteurs : Yi-Ming Arthur Chen [Taïwan] ; Shu-Yuan Liang [Taïwan] ; Yi-Ping Shih [Taïwan] ; Chia-Yen Chen [Taïwan] ; Yuan-Ming Lee [Taïwan] ; LING CHANG [Taïwan] ; Shiao-Ying Jung [Taïwan] ; Mei-Shang Ho [Taïwan] ; Kung-Yee Liang [Taïwan] ; Hour-Young Chen [Taïwan] ; Yu-Jiun Chan [Taïwan] ; Da-Chen Chu [Taïwan]Source :
- Journal of clinical microbiology : (Print) [ 0095-1137 ] ; 2006.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Anticorps antiviraux (sang), Antigènes HLA-C (génétique), Enquêtes et questionnaires, Facteurs de risque, Femelle, Flambées de maladies, Humains, Hôpitaux urbains, Infection croisée (virologie), Infection croisée (épidémiologie), Mâle, Souris, Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Taïwan (épidémiologie), Technique de Western, Test ELISA, Test d'histocompatibilité, Tests de neutralisation, Virus du SRAS (immunologie).
- MESH :
- génétique : Antigènes HLA-C, Syndrome respiratoire aigu sévère.
- immunologie : Virus du SRAS.
- sang : Anticorps antiviraux.
- virologie : Infection croisée, Syndrome respiratoire aigu sévère.
- épidémiologie : Infection croisée, Syndrome respiratoire aigu sévère, Taïwan.
- Pascal (Inist)
- Adulte, Adulte d'âge moyen, Animaux, Coronavirus, Enquêtes et questionnaires, Facteurs de risque, Femelle, Flambées de maladies, Génétique, Humains, Hôpitaux urbains, Incidence, Mâle, Souris, Taiwan, Microbiologie, Syndrome respiratoire aigu sévère, Infection nosocomiale, Technique de Western, Test ELISA, Test d'histocompatibilité, Tests de neutralisation.
- Wicri :
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Viral (blood), Blotting, Western, Coronavirus, Cross Infection (epidemiology), Cross Infection (virology), Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Female, Genetics, HLA-C Antigens (genetics), Histocompatibility Testing, Hospitals, Urban, Humans, Incidence, Male, Mice, Microbiology, Middle Aged, Neutralization Tests, Nosocomial infection, Risk Factors, SARS Virus (immunology), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Surveys and Questionnaires, Taiwan, Taiwan (epidemiology).
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : Taiwan.
- epidemiology : Cross Infection, Severe Acute Respiratory Syndrome.
- chemical , genetics : HLA-C Antigens, Severe Acute Respiratory Syndrome.
- immunology : SARS Virus.
- virology : Cross Infection, Severe Acute Respiratory Syndrome.
- Adult, Animals, Blotting, Western, Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Female, Histocompatibility Testing, Hospitals, Urban, Humans, Male, Mice, Middle Aged, Neutralization Tests, Risk Factors, Surveys and Questionnaires.
Abstract
Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9; P = 0.007).
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and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003</title><author><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Prevention and Research Center, Institute of Public Health, National Yang-Ming University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Shu Yuan" sort="Liang, Shu Yuan" uniqKey="Liang S" first="Shu-Yuan" last="Liang">Shu-Yuan Liang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Prevention and Research Center, Institute of Public Health, National Yang-Ming University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Shih, Yi Ping" sort="Shih, Yi Ping" uniqKey="Shih Y" first="Yi-Ping" last="Shih">Yi-Ping Shih</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Prevention and Research Center, Institute of Public Health, National Yang-Ming University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chia Yen" sort="Chen, Chia Yen" uniqKey="Chen C" first="Chia-Yen" last="Chen">Chia-Yen Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Prevention and Research Center, Institute of Public Health, National Yang-Ming University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Prevention and Research Center, Institute of Public Health, National Yang-Ming University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Ling Chang" sort="Ling Chang" uniqKey="Ling Chang" last="Ling Chang">LING CHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>AIDS Prevention and Research Center, Institute of Public Health, National Yang-Ming University</s1><s2>Taipei</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Jung, Shiao Ying" sort="Jung, Shiao Ying" uniqKey="Jung S" first="Shiao-Ying" last="Jung">Shiao-Ying Jung</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Wanhua District Health Center, Taipei City Government</s1><s2>Taipei</s2><s3>TWN</s3><sZ>7 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biomedical Science, Academia Sinica</s1><s2>Taipei</s2><s3>TWN</s3><sZ>8 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Kung Yee" sort="Liang, Kung Yee" uniqKey="Liang K" first="Kung-Yee" last="Liang">Kung-Yee Liang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Health Research Institutes, Zhunan Township</s1><s2>Miaoli County</s2><s3>TWN</s3><sZ>9 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Miaoli County</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hour Young" sort="Chen, Hour Young" uniqKey="Chen H" first="Hour-Young" last="Chen">Hour-Young Chen</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Center for Disease Control, Department of Health, Republic of China Executive Yuan</s1><s2>Taipei</s2><s3>TWN</s3><sZ>10 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Clinical Virology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital</s1><s2>Taipei</s2><s3>TWN</s3><sZ>11 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Da Chen" sort="Chu, Da Chen" uniqKey="Chu D" first="Da-Chen" last="Chu">Da-Chen Chu</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Division for Disease Control, Taipei City Hospital</s1><s2>Taipei</s2><s3>TWN</s3><sZ>12 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of clinical microbiology : (Print)</title><title level="j" type="abbreviated">J. clin. microbiol. : (Print)</title><idno type="ISSN">0095-1137</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of clinical microbiology : (Print)</title><title level="j" type="abbreviated">J. clin. microbiol. : (Print)</title><idno type="ISSN">0095-1137</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Blotting, Western</term><term>Coronavirus</term><term>Cross Infection (epidemiology)</term><term>Cross Infection (virology)</term><term>Disease Outbreaks</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Genetics</term><term>HLA-C Antigens (genetics)</term><term>Histocompatibility Testing</term><term>Hospitals, Urban</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Mice</term><term>Microbiology</term><term>Middle Aged</term><term>Neutralization Tests</term><term>Nosocomial infection</term><term>Risk Factors</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (genetics)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severe acute respiratory syndrome</term><term>Surveys and Questionnaires</term><term>Taiwan</term><term>Taiwan (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Antigènes HLA-C (génétique)</term><term>Enquêtes et questionnaires</term><term>Facteurs de risque</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Hôpitaux urbains</term><term>Infection croisée (virologie)</term><term>Infection croisée (épidémiologie)</term><term>Mâle</term><term>Souris</term><term>Syndrome respiratoire aigu sévère (génétique)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Taïwan (épidémiologie)</term><term>Technique de Western</term><term>Test ELISA</term><term>Test d'histocompatibilité</term><term>Tests de neutralisation</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Taiwan</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cross Infection</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-C Antigens</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-C</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infection croisée</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cross Infection</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infection croisée</term><term>Syndrome respiratoire aigu sévère</term><term>Taïwan</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Blotting, Western</term><term>Disease Outbreaks</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Histocompatibility Testing</term><term>Hospitals, Urban</term><term>Humans</term><term>Male</term><term>Mice</term><term>Middle Aged</term><term>Neutralization Tests</term><term>Risk Factors</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Coronavirus</term><term>Enquêtes et questionnaires</term><term>Facteurs de risque</term><term>Femelle</term><term>Flambées de maladies</term><term>Génétique</term><term>Humains</term><term>Hôpitaux urbains</term><term>Incidence</term><term>Mâle</term><term>Souris</term><term>Taiwan</term><term>Microbiologie</term><term>Syndrome respiratoire aigu sévère</term><term>Infection nosocomiale</term><term>Technique de Western</term><term>Test ELISA</term><term>Test d'histocompatibilité</term><term>Tests de neutralisation</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Taïwan</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9; P = 0.007).</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name></noRegion><name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name><name sortKey="Chen, Chia Yen" sort="Chen, Chia Yen" uniqKey="Chen C" first="Chia-Yen" last="Chen">Chia-Yen Chen</name><name sortKey="Chen, Hour Young" sort="Chen, Hour Young" uniqKey="Chen H" first="Hour-Young" last="Chen">Hour-Young Chen</name><name sortKey="Chu, Da Chen" sort="Chu, Da Chen" uniqKey="Chu D" first="Da-Chen" last="Chu">Da-Chen Chu</name><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name><name sortKey="Jung, Shiao Ying" sort="Jung, Shiao Ying" uniqKey="Jung S" first="Shiao-Ying" last="Jung">Shiao-Ying Jung</name><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name><name sortKey="Liang, Kung Yee" sort="Liang, Kung Yee" uniqKey="Liang K" first="Kung-Yee" last="Liang">Kung-Yee Liang</name><name sortKey="Liang, Shu Yuan" sort="Liang, Shu Yuan" uniqKey="Liang S" first="Shu-Yuan" last="Liang">Shu-Yuan Liang</name><name sortKey="Ling Chang" sort="Ling Chang" uniqKey="Ling Chang" last="Ling Chang">LING CHANG</name><name sortKey="Shih, Yi Ping" sort="Shih, Yi Ping" uniqKey="Shih Y" first="Yi-Ping" last="Shih">Yi-Ping Shih</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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