Epidemiological and Genetic Correlates of Severe Acute Respiratory Syndrome Coronavirus Infection in the Hospital with the Highest Nosocomial Infection Rate in Taiwan in 2003†
Identifieur interne : 000656 ( Pmc/Corpus ); précédent : 000655; suivant : 000657Epidemiological and Genetic Correlates of Severe Acute Respiratory Syndrome Coronavirus Infection in the Hospital with the Highest Nosocomial Infection Rate in Taiwan in 2003†
Auteurs : Yi-Ming Arthur Chen ; Shu-Yuan Liang ; Yi-Ping Shih ; Chia-Yen Chen ; Yuan-Ming Lee ; Ling Chang ; Shiao-Ying Jung ; Mei-Shang Ho ; Kung-Yee Liang ; Hour-Young Chen ; Yu-Jiun Chan ; Da-Chen ChuSource :
- Journal of Clinical Microbiology [ 0095-1137 ] ; 2006.
Abstract
Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9;
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DOI: 10.1128/JCM.44.2.359-365.2006
PubMed: 16455884
PubMed Central: 1392693
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last="Chen">Chia-Yen Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chang, Ling" sort="Chang, Ling" uniqKey="Chang L" first="Ling" last="Chang">Ling Chang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Jung, Shiao Ying" sort="Jung, Shiao Ying" uniqKey="Jung S" first="Shiao-Ying" last="Jung">Shiao-Ying Jung</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liang, Kung Yee" sort="Liang, Kung Yee" uniqKey="Liang K" first="Kung-Yee" last="Liang">Kung-Yee Liang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Hour Young" sort="Chen, Hour Young" uniqKey="Chen H" first="Hour-Young" last="Chen">Hour-Young Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chu, Da Chen" sort="Chu, Da Chen" uniqKey="Chu D" first="Da-Chen" last="Chu">Da-Chen Chu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16455884</idno><idno type="pmc">1392693</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392693</idno><idno type="RBID">PMC:1392693</idno><idno type="doi">10.1128/JCM.44.2.359-365.2006</idno><date when="2006">2006</date><idno 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Shih</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Chia Yen" sort="Chen, Chia Yen" uniqKey="Chen C" first="Chia-Yen" last="Chen">Chia-Yen Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chang, Ling" sort="Chang, Ling" uniqKey="Chang L" first="Ling" last="Chang">Ling Chang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Jung, Shiao Ying" sort="Jung, Shiao Ying" uniqKey="Jung S" first="Shiao-Ying" last="Jung">Shiao-Ying Jung</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liang, Kung Yee" sort="Liang, Kung Yee" uniqKey="Liang K" first="Kung-Yee" last="Liang">Kung-Yee Liang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Hour Young" sort="Chen, Hour Young" uniqKey="Chen H" first="Hour-Young" last="Chen">Hour-Young Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chu, Da Chen" sort="Chu, Da Chen" uniqKey="Chu D" first="Da-Chen" last="Chu">Da-Chen Chu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Microbiology</title><idno type="ISSN">0095-1137</idno><idno type="eISSN">1098-660X</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9; <italic>P</italic> = 0.007).</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Microbiol</journal-id><journal-id journal-id-type="publisher-id">jcm</journal-id><journal-title>Journal of Clinical Microbiology</journal-title><issn pub-type="ppub">0095-1137</issn><issn pub-type="epub">1098-660X</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16455884</article-id><article-id pub-id-type="pmc">1392693</article-id><article-id pub-id-type="publisher-id">1997-05</article-id><article-id pub-id-type="doi">10.1128/JCM.44.2.359-365.2006</article-id><article-categories><subj-group subj-group-type="heading"><subject>Virology</subject></subj-group></article-categories><title-group><article-title>Epidemiological and Genetic Correlates of Severe Acute Respiratory Syndrome Coronavirus Infection in the Hospital with the Highest Nosocomial Infection Rate in Taiwan in 2003<xref ref-type="fn" rid="fn1">†</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Yi-Ming Arthur</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Liang</surname><given-names>Shu-Yuan</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shih</surname><given-names>Yi-Ping</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Chia-Yen</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Yuan-Ming</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Ling</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jung</surname><given-names>Shiao-Ying</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Mei-Shang</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Liang</surname><given-names>Kung-Yee</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Hour-Young</given-names></name><xref ref-type="aff" rid="aff1">5</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Yu-Jiun</given-names></name><xref ref-type="aff" rid="aff1">6</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Da-Chen</given-names></name><xref ref-type="aff" rid="aff1">7</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1">AIDS Prevention and Research Center, Institute of Public Health, National Yang-Ming University, Taipei, Taiwan,<label>1</label> Wanhua District Health Center, Taipei City Government, Taipei, Taiwan,<label>2</label> Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan,<label>3</label> National Health Research Institutes, Zhunan Township, Miaoli County, Taiwan,<label>4</label> Center for Disease Control, Department of Health, Republic of China Executive Yuan, Taipei, Taiwan,<label>5</label> Division of Clinical Virology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan,<label>6</label> Division for Disease Control, Taipei City Hospital, Taipei, Taiwan<label>7</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address for Yi-Ming Chen: Institute of Public Health, National Yang-Ming University, Li-Noun Street, Section 2, Taipei, Taiwan 112. Phone: 886-2-28267193. Fax: 886-2-28270576. E-mail: <email>arthur@ym.edu.tw</email>. Mailing address for Da-Chen Chu: Division for Disease Control, Taipei City Hospital, Taipei, Taiwan. Phone: 886-2-23889595. Fax: 886-2-23711407. E-mail: <email>hoping@tpech.gov.tw</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>2</month><year>2006</year></pub-date><volume>44</volume><issue>2</issue><fpage>359</fpage><lpage>365</lpage><history><date date-type="received"><day>23</day><month>9</month><year>2005</year></date><date date-type="rev-recd"><day>10</day><month>11</month><year>2005</year></date><date date-type="accepted"><day>22</day><month>11</month><year>2005</year></date></history><copyright-statement>Copyright © 2006, American Society for Microbiology</copyright-statement><copyright-year>2006</copyright-year><abstract><p>Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9; <italic>P</italic> = 0.007).</p></abstract><custom-meta-wrap><custom-meta><meta-name>PDF filename</meta-name><meta-value>zjm00206000359</meta-value></custom-meta></custom-meta-wrap></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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