SrasV1, PascalFrancis, Curation, bibRecord, 000445

Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003

Identifieur interne : 000445 ( PascalFrancis/Curation ); précédent : 000444; suivant : 000446

Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003

Auteurs : Yi-Ming Arthur Chen [Taïwan] ; Shu-Yuan Liang [Taïwan] ; Yi-Ping Shih [Taïwan] ; Chia-Yen Chen [Taïwan] ; Yuan-Ming Lee [Taïwan] ; LING CHANG [Taïwan] ; Shiao-Ying Jung [Taïwan] ; Mei-Shang Ho [Taïwan] ; Kung-Yee Liang [Taïwan] ; Hour-Young Chen [Taïwan] ; Yu-Jiun Chan [Taïwan] ; Da-Chen Chu [Taïwan]

Source :

Journal of clinical microbiology : (Print) [ 0095-1137 ] ; 2006.

RBID : Pascal:06-0127171

Descripteurs français

Pascal (Inist)
- Coronavirus, Génétique, Incidence, Taiwan, Microbiologie, Syndrome respiratoire aigu sévère, Infection nosocomiale.
Wicri :
- topic : Génétique.

English descriptors

KwdEn :
- Coronavirus, Genetics, Incidence, Microbiology, Nosocomial infection, Severe acute respiratory syndrome, Taiwan.

Abstract

Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9; P = 0.007).

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003</title>
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<author><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name>
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<author><name sortKey="Ling Chang" sort="Ling Chang" uniqKey="Ling Chang" last="Ling Chang">LING CHANG</name>
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<author><name sortKey="Jung, Shiao Ying" sort="Jung, Shiao Ying" uniqKey="Jung S" first="Shiao-Ying" last="Jung">Shiao-Ying Jung</name>
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<author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name>
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<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
</affiliation>
</author>
<author><name sortKey="Liang, Kung Yee" sort="Liang, Kung Yee" uniqKey="Liang K" first="Kung-Yee" last="Liang">Kung-Yee Liang</name>
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<author><name sortKey="Chen, Hour Young" sort="Chen, Hour Young" uniqKey="Chen H" first="Hour-Young" last="Chen">Hour-Young Chen</name>
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<s3>TWN</s3>
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<country>Taïwan</country>
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<author><name sortKey="Chan, Yu Jiun" sort="Chan, Yu Jiun" uniqKey="Chan Y" first="Yu-Jiun" last="Chan">Yu-Jiun Chan</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Clinical Virology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital</s1>
<s2>Taipei</s2>
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<author><name sortKey="Chu, Da Chen" sort="Chu, Da Chen" uniqKey="Chu D" first="Da-Chen" last="Chu">Da-Chen Chu</name>
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<front><div type="abstract" xml:lang="en">Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9; P = 0.007).</div>
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Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003

Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003

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