Epidemiological and Genetic Correlates of Severe Acute Respiratory Syndrome Coronavirus Infection in the Hospital with the Highest Nosocomial Infection Rate in Taiwan in 2003†
Identifieur interne : 004101 ( Main/Merge ); précédent : 004100; suivant : 004102Epidemiological and Genetic Correlates of Severe Acute Respiratory Syndrome Coronavirus Infection in the Hospital with the Highest Nosocomial Infection Rate in Taiwan in 2003†
Auteurs : Yi-Ming Arthur Chen ; Shu-Yuan Liang ; Yi-Ping Shih ; Chia-Yen Chen ; Yuan-Ming Lee ; Ling Chang ; Shiao-Ying Jung ; Mei-Shang Ho ; Kung-Yee Liang ; Hour-Young Chen ; Yu-Jiun Chan ; Da-Chen ChuSource :
- Journal of Clinical Microbiology [ 0095-1137 ] ; 2006.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Anticorps antiviraux (sang), Antigènes HLA-C (génétique), Enquêtes et questionnaires, Facteurs de risque, Femelle, Flambées de maladies, Humains, Hôpitaux urbains, Infection croisée (virologie), Infection croisée (épidémiologie), Mâle, Souris, Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Taïwan (épidémiologie), Technique de Western, Test ELISA, Test d'histocompatibilité, Tests de neutralisation, Virus du SRAS (immunologie).
- MESH :
- génétique : Antigènes HLA-C, Syndrome respiratoire aigu sévère.
- immunologie : Virus du SRAS.
- sang : Anticorps antiviraux.
- virologie : Infection croisée, Syndrome respiratoire aigu sévère.
- épidémiologie : Infection croisée, Syndrome respiratoire aigu sévère, Taïwan.
- Adulte, Adulte d'âge moyen, Animaux, Enquêtes et questionnaires, Facteurs de risque, Femelle, Flambées de maladies, Humains, Hôpitaux urbains, Mâle, Souris, Technique de Western, Test ELISA, Test d'histocompatibilité, Tests de neutralisation.
- Wicri :
- geographic : Taïwan.
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Viral (blood), Blotting, Western, Cross Infection (epidemiology), Cross Infection (virology), Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Female, HLA-C Antigens (genetics), Histocompatibility Testing, Hospitals, Urban, Humans, Male, Mice, Middle Aged, Neutralization Tests, Risk Factors, SARS Virus (immunology), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (virology), Surveys and Questionnaires, Taiwan (epidemiology).
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : Taiwan.
- epidemiology : Cross Infection, Severe Acute Respiratory Syndrome.
- chemical , genetics : HLA-C Antigens, Severe Acute Respiratory Syndrome.
- immunology : SARS Virus.
- virology : Cross Infection, Severe Acute Respiratory Syndrome.
- Adult, Animals, Blotting, Western, Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Female, Histocompatibility Testing, Hospitals, Urban, Humans, Male, Mice, Middle Aged, Neutralization Tests, Risk Factors, Surveys and Questionnaires.
Abstract
Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9;
Url:
DOI: 10.1128/JCM.44.2.359-365.2006
PubMed: 16455884
PubMed Central: 1392693
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PMC:1392693Le document en format XML
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sort="Shih, Yi Ping" uniqKey="Shih Y" first="Yi-Ping" last="Shih">Yi-Ping Shih</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Chia Yen" sort="Chen, Chia Yen" uniqKey="Chen C" first="Chia-Yen" last="Chen">Chia-Yen Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lee, Yuan Ming" sort="Lee, Yuan Ming" uniqKey="Lee Y" first="Yuan-Ming" last="Lee">Yuan-Ming Lee</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chang, Ling" sort="Chang, Ling" uniqKey="Chang L" first="Ling" last="Chang">Ling Chang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Jung, Shiao Ying" sort="Jung, Shiao Ying" uniqKey="Jung S" first="Shiao-Ying" last="Jung">Shiao-Ying Jung</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" 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Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Taiwan</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cross Infection</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-C Antigens</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-C</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infection croisée</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cross Infection</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infection croisée</term><term>Syndrome respiratoire aigu sévère</term><term>Taïwan</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Blotting, Western</term><term>Disease Outbreaks</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Histocompatibility Testing</term><term>Hospitals, Urban</term><term>Humans</term><term>Male</term><term>Mice</term><term>Middle Aged</term><term>Neutralization Tests</term><term>Risk Factors</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enquêtes et questionnaires</term><term>Facteurs de risque</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Hôpitaux urbains</term><term>Mâle</term><term>Souris</term><term>Technique de Western</term><term>Test ELISA</term><term>Test d'histocompatibilité</term><term>Tests de neutralisation</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Taïwan</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (SARS) infections in 2003. Two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe SARS infections to help us investigate epidemiological and genetic factors associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were detected by using enzyme immunoassays and confirmed by a combination of Western blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors were analyzed via questionnaire responses and sequence-specific oligonucleotide probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% (20/658) of the study participants were seropositive, with one female nurse identified as a subclinical case. Identified SARS-CoV infection risk factors include working in the same building as the hospital's emergency room and infection ward, providing direct care to SARS patients, and carrying a Cw*0801 HLA allele. The odds ratio for contracting a SARS-CoV infection among persons with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% confidence interval, 1.5 to 12.9; <italic>P</italic> = 0.007).</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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