Antiviral Effects of Glycyrrhiza species
Identifieur interne : 003518 ( Main/Exploration ); précédent : 003517; suivant : 003519Antiviral Effects of Glycyrrhiza species
Auteurs : Cristina Fiore [Italie] ; Michael Eisenhut [Royaume-Uni] ; Rea Krausse [Allemagne] ; Eugenio Ragazzi [Italie] ; Donatella Pellati [Italie] ; Decio Armanini [Italie] ; Jens Bielenberg [Allemagne]Source :
- PTR. Phytotherapy research [ 0951-418X ] ; 2008.
Descripteurs français
- KwdFr :
- Acide glycyrrhizique (), Acide glycyrrhizique (pharmacologie), Animaux, Antiviraux (), Antiviraux (pharmacologie), Extraits de plantes (), Extraits de plantes (pharmacologie), Glycyrrhiza (), Humains, Plantes médicinales (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), Énoxolone (), Énoxolone (pharmacologie).
- MESH :
- pharmacologie : Acide glycyrrhizique, Antiviraux, Extraits de plantes, Énoxolone.
- Pascal (Inist)
- Acide glycyrrhizique, Animaux, Antiviral, Antiviraux, Espèce, Extraits de plantes, Glycyrrhiza, Humains, Plantes médicinales, Réglisse, Acide glycyrrhizique, Enoxolone, Grippe, Hépatite, Relation structure activité, Pharmacognosie, Plante médicinale, Glycyrrhiza glabra, Origine végétale, Leguminosae, Saponine, Dérivé de l'oléanane, Acide uronique, Antiinflammatoire, Glycoside, Triterpène, Terpénoïde, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Énoxolone.
- Wicri :
- topic : Plante médicinale.
English descriptors
- KwdEn :
- Animals, Antiinflammatory agent, Antiviral, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Enoxolone, Glycoside, Glycyrrhetinic Acid (chemistry), Glycyrrhetinic Acid (pharmacology), Glycyrrhiza (chemistry), Glycyrrhiza glabra, Glycyrrhizic Acid (chemistry), Glycyrrhizic Acid (pharmacology), Glycyrrhizic acid, HIV-1 (drug effects), Hepatitis, Humans, Influenza, Leguminosae, Licorice, Medicinal plant, Oleanane derivatives, Pharmacognosy, Plant Extracts (chemistry), Plant Extracts (pharmacology), Plant origin, Plants, Medicinal (chemistry), Saponin, Species, Structure activity relation, Terpenoid, Triterpene, Uronic acid.
- MESH :
- chemical , chemistry : Antiviral Agents, Glycyrrhetinic Acid, Glycyrrhizic Acid, Plant Extracts.
- chemical , pharmacology : Antiviral Agents, Glycyrrhetinic Acid, Glycyrrhizic Acid, Plant Extracts.
- chemistry : Glycyrrhiza, Plants, Medicinal.
- drug effects : HIV-1.
- Animals, Humans.
Abstract
Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus-induced cirrhosis the risk of hepatocellular carcinoma was reduced. Animal studies demonstrated a reduction of mortality and viral activity in herpes simplex virus encephalitis and influenza A virus pneumonia. In vitro studies revealed antiviral activity against HIV-1, SARS related coronavirus, respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus. Mechanisms for antiviral activity of Glycyrrhiza spp. include reduced transport to the membrane and sialylation of hepatitis B virus surface antigen, reduction of membrane fluidity leading to inhibition of fusion of the viral membrane of HIV-1 with the cell, induction of interferon gamma in T-cells, inhibition of phosphorylating enzymes in vesicular stomatitis virus infection and reduction of viral latency. Future research needs to explore the potency of compounds derived from licorice in prevention and treatment of influenza A virus pneumonia and as an adjuvant treatment in patients infected with HIV resistant to antiretroviral drugs.
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antiinflammatory agent</term>
<term>Antiviral</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Enoxolone</term>
<term>Glycoside</term>
<term>Glycyrrhetinic Acid (chemistry)</term>
<term>Glycyrrhetinic Acid (pharmacology)</term>
<term>Glycyrrhiza (chemistry)</term>
<term>Glycyrrhiza glabra</term>
<term>Glycyrrhizic Acid (chemistry)</term>
<term>Glycyrrhizic Acid (pharmacology)</term>
<term>Glycyrrhizic acid</term>
<term>HIV-1 (drug effects)</term>
<term>Hepatitis</term>
<term>Humans</term>
<term>Influenza</term>
<term>Leguminosae</term>
<term>Licorice</term>
<term>Medicinal plant</term>
<term>Oleanane derivatives</term>
<term>Pharmacognosy</term>
<term>Plant Extracts (chemistry)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plant origin</term>
<term>Plants, Medicinal (chemistry)</term>
<term>Saponin</term>
<term>Species</term>
<term>Structure activity relation</term>
<term>Terpenoid</term>
<term>Triterpene</term>
<term>Uronic acid</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide glycyrrhizique ()</term>
<term>Acide glycyrrhizique (pharmacologie)</term>
<term>Animaux</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Extraits de plantes ()</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Glycyrrhiza ()</term>
<term>Humains</term>
<term>Plantes médicinales ()</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>Énoxolone ()</term>
<term>Énoxolone (pharmacologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term>
<term>Glycyrrhetinic Acid</term>
<term>Glycyrrhizic Acid</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Glycyrrhetinic Acid</term>
<term>Glycyrrhizic Acid</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Glycyrrhiza</term>
<term>Plants, Medicinal</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide glycyrrhizique</term>
<term>Antiviraux</term>
<term>Extraits de plantes</term>
<term>Énoxolone</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Acide glycyrrhizique</term>
<term>Animaux</term>
<term>Antiviral</term>
<term>Antiviraux</term>
<term>Espèce</term>
<term>Extraits de plantes</term>
<term>Glycyrrhiza</term>
<term>Humains</term>
<term>Plantes médicinales</term>
<term>Réglisse</term>
<term>Acide glycyrrhizique</term>
<term>Enoxolone</term>
<term>Grippe</term>
<term>Hépatite</term>
<term>Relation structure activité</term>
<term>Pharmacognosie</term>
<term>Plante médicinale</term>
<term>Glycyrrhiza glabra</term>
<term>Origine végétale</term>
<term>Leguminosae</term>
<term>Saponine</term>
<term>Dérivé de l'oléanane</term>
<term>Acide uronique</term>
<term>Antiinflammatoire</term>
<term>Glycoside</term>
<term>Triterpène</term>
<term>Terpénoïde</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>Énoxolone</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plante médicinale</term>
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<front><div type="abstract" xml:lang="en">Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus-induced cirrhosis the risk of hepatocellular carcinoma was reduced. Animal studies demonstrated a reduction of mortality and viral activity in herpes simplex virus encephalitis and influenza A virus pneumonia. In vitro studies revealed antiviral activity against HIV-1, SARS related coronavirus, respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus. Mechanisms for antiviral activity of Glycyrrhiza spp. include reduced transport to the membrane and sialylation of hepatitis B virus surface antigen, reduction of membrane fluidity leading to inhibition of fusion of the viral membrane of HIV-1 with the cell, induction of interferon gamma in T-cells, inhibition of phosphorylating enzymes in vesicular stomatitis virus infection and reduction of viral latency. Future research needs to explore the potency of compounds derived from licorice in prevention and treatment of influenza A virus pneumonia and as an adjuvant treatment in patients infected with HIV resistant to antiretroviral drugs.</div>
</front>
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<affiliations><list><country><li>Allemagne</li>
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<li>Royaume-Uni</li>
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<tree><country name="Italie"><noRegion><name sortKey="Fiore, Cristina" sort="Fiore, Cristina" uniqKey="Fiore C" first="Cristina" last="Fiore">Cristina Fiore</name>
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<name sortKey="Bielenberg, Jens" sort="Bielenberg, Jens" uniqKey="Bielenberg J" first="Jens" last="Bielenberg">Jens Bielenberg</name>
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