Antiviral effects of Glycyrrhiza species.
Identifieur interne : 001A72 ( Ncbi/Curation ); précédent : 001A71; suivant : 001A73Antiviral effects of Glycyrrhiza species.
Auteurs : Cristina Fiore [Italie] ; Michael Eisenhut ; Rea Krausse ; Eugenio Ragazzi ; Donatella Pellati ; Decio Armanini ; Jens BielenbergSource :
- Phytotherapy research : PTR [ 0951-418X ] ; 2008.
Descripteurs français
- KwdFr :
- Acide glycyrrhizique (), Acide glycyrrhizique (pharmacologie), Animaux, Antiviraux (), Antiviraux (pharmacologie), Extraits de plantes (), Extraits de plantes (pharmacologie), Glycyrrhiza (), Humains, Plantes médicinales (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), Énoxolone (), Énoxolone (pharmacologie).
- MESH :
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Glycyrrhetinic Acid (chemistry), Glycyrrhetinic Acid (pharmacology), Glycyrrhiza (chemistry), Glycyrrhizic Acid (chemistry), Glycyrrhizic Acid (pharmacology), HIV-1 (drug effects), Humans, Plant Extracts (chemistry), Plant Extracts (pharmacology), Plants, Medicinal (chemistry).
- MESH :
- chemical , chemistry : Antiviral Agents, Glycyrrhetinic Acid, Glycyrrhizic Acid, Plant Extracts.
- chemical , pharmacology : Antiviral Agents, Glycyrrhetinic Acid, Glycyrrhizic Acid, Plant Extracts.
- chemistry : Glycyrrhiza, Plants, Medicinal.
- drug effects : HIV-1.
- Animals, Humans.
Abstract
Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus-induced cirrhosis the risk of hepatocellular carcinoma was reduced. Animal studies demonstrated a reduction of mortality and viral activity in herpes simplex virus encephalitis and influenza A virus pneumonia. In vitro studies revealed antiviral activity against HIV-1, SARS related coronavirus, respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus. Mechanisms for antiviral activity of Glycyrrhiza spp. include reduced transport to the membrane and sialylation of hepatitis B virus surface antigen, reduction of membrane fluidity leading to inhibition of fusion of the viral membrane of HIV-1 with the cell, induction of interferon gamma in T-cells, inhibition of phosphorylating enzymes in vesicular stomatitis virus infection and reduction of viral latency. Future research needs to explore the potency of compounds derived from licorice in prevention and treatment of influenza A virus pneumonia and as an adjuvant treatment in patients infected with HIV resistant to antiretroviral drugs.
DOI: 10.1002/ptr.2295
PubMed: 17886224
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first="Eugenio" last="Ragazzi">Eugenio Ragazzi</name></author><author><name sortKey="Pellati, Donatella" sort="Pellati, Donatella" uniqKey="Pellati D" first="Donatella" last="Pellati">Donatella Pellati</name></author><author><name sortKey="Armanini, Decio" sort="Armanini, Decio" uniqKey="Armanini D" first="Decio" last="Armanini">Decio Armanini</name></author><author><name sortKey="Bielenberg, Jens" sort="Bielenberg, Jens" uniqKey="Bielenberg J" first="Jens" last="Bielenberg">Jens Bielenberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:17886224</idno><idno type="pmid">17886224</idno><idno type="doi">10.1002/ptr.2295</idno><idno type="wicri:Area/PubMed/Corpus">001D18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D18</idno><idno type="wicri:Area/PubMed/Curation">001D18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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first="Michael" last="Eisenhut">Michael Eisenhut</name></author><author><name sortKey="Krausse, Rea" sort="Krausse, Rea" uniqKey="Krausse R" first="Rea" last="Krausse">Rea Krausse</name></author><author><name sortKey="Ragazzi, Eugenio" sort="Ragazzi, Eugenio" uniqKey="Ragazzi E" first="Eugenio" last="Ragazzi">Eugenio Ragazzi</name></author><author><name sortKey="Pellati, Donatella" sort="Pellati, Donatella" uniqKey="Pellati D" first="Donatella" last="Pellati">Donatella Pellati</name></author><author><name sortKey="Armanini, Decio" sort="Armanini, Decio" uniqKey="Armanini D" first="Decio" last="Armanini">Decio Armanini</name></author><author><name sortKey="Bielenberg, Jens" sort="Bielenberg, Jens" uniqKey="Bielenberg J" first="Jens" last="Bielenberg">Jens Bielenberg</name></author></analytic><series><title level="j">Phytotherapy research : PTR</title><idno type="ISSN">0951-418X</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Glycyrrhetinic Acid (chemistry)</term><term>Glycyrrhetinic Acid (pharmacology)</term><term>Glycyrrhiza (chemistry)</term><term>Glycyrrhizic Acid (chemistry)</term><term>Glycyrrhizic Acid (pharmacology)</term><term>HIV-1 (drug effects)</term><term>Humans</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Plants, Medicinal (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide glycyrrhizique ()</term><term>Acide glycyrrhizique (pharmacologie)</term><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Extraits de plantes ()</term><term>Extraits de plantes (pharmacologie)</term><term>Glycyrrhiza ()</term><term>Humains</term><term>Plantes médicinales ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>Énoxolone ()</term><term>Énoxolone (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Glycyrrhetinic Acid</term><term>Glycyrrhizic Acid</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Glycyrrhetinic Acid</term><term>Glycyrrhizic Acid</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Glycyrrhiza</term><term>Plants, Medicinal</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide glycyrrhizique</term><term>Antiviraux</term><term>Extraits de plantes</term><term>Énoxolone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide glycyrrhizique</term><term>Animaux</term><term>Antiviraux</term><term>Extraits de plantes</term><term>Glycyrrhiza</term><term>Humains</term><term>Plantes médicinales</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Énoxolone</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus-induced cirrhosis the risk of hepatocellular carcinoma was reduced. Animal studies demonstrated a reduction of mortality and viral activity in herpes simplex virus encephalitis and influenza A virus pneumonia. In vitro studies revealed antiviral activity against HIV-1, SARS related coronavirus, respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus. Mechanisms for antiviral activity of Glycyrrhiza spp. include reduced transport to the membrane and sialylation of hepatitis B virus surface antigen, reduction of membrane fluidity leading to inhibition of fusion of the viral membrane of HIV-1 with the cell, induction of interferon gamma in T-cells, inhibition of phosphorylating enzymes in vesicular stomatitis virus infection and reduction of viral latency. Future research needs to explore the potency of compounds derived from licorice in prevention and treatment of influenza A virus pneumonia and as an adjuvant treatment in patients infected with HIV resistant to antiretroviral drugs.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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