SrasV1, Main, Exploration, bibRecordById, Pascal:06-0407325

Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients

Identifieur interne : 004434 ( Main/Exploration ); précédent : 004433; suivant : 004435

Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients

Auteurs : Li-Tao Yang [République populaire de Chine] ; HUI PONG [République populaire de Chine] ; Zhao-Ling Zhu [République populaire de Chine] ; GANG LI [République populaire de Chine] ; Zi-Tong Huang [République populaire de Chine] ; Zhi-Xin Zhao [République populaire de Chine] ; Richard A. Koup [États-Unis] ; Robert T. Bailer [États-Unis] ; Chang-You Wu [République populaire de Chine]

Source :

Clinical immunology : (Orlando, Fla. Print) [ 1521-6616 ] ; 2006.

RBID : Pascal:06-0407325

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Cellule effectrice, Lymphocyte T, Protéine S, Réponse immune, Coronavirus, Interféron gamma, Antigène, Homme, Immunité cellulaire, Lymphocyte mémoire.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antigen, Cellular immunity, Coronavirus, Effectory cell, Gamma interferon, Human, Immune response, Memory lymphocyte, Protein S, Severe acute respiratory syndrome, T-Lymphocyte.

Abstract

The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4⁺ and CD8⁺ T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4⁺ Tcells were central memory cells expressing CD45RO⁺ CCR7⁺ CD62L-. However, the majority of memory CD8⁺ T cells revealed effector memory phenotype expressing CD45RO^- CCR7^- CD62L-. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106132

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4<sup>+</sup>
 and CD8<sup>+</sup>
 T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4<sup>+</sup>
 Tcells were central memory cells expressing CD45RO<sup>+</sup>
 CCR7<sup>+</sup>
 CD62L-. However, the majority of memory CD8<sup>+</sup>
 T cells revealed effector memory phenotype expressing CD45RO<sup>-</sup>
 CCR7<sup>-</sup>
 CD62L-. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.</div>
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Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients

Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients

Source :

Descripteurs français

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Abstract

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