SrasV1, PascalFrancis, Curation, bibRecord, 000522

Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients

Identifieur interne : 000522 ( PascalFrancis/Curation ); précédent : 000521; suivant : 000523

Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients

Auteurs : Li-Tao Yang [République populaire de Chine] ; HUI PONG [République populaire de Chine] ; Zhao-Ling Zhu [République populaire de Chine] ; GANG LI [République populaire de Chine] ; Zi-Tong Huang [République populaire de Chine] ; Zhi-Xin Zhao [République populaire de Chine] ; Richard A. Koup [États-Unis] ; Robert T. Bailer [États-Unis] ; Chang-You Wu [République populaire de Chine]

Source :

Clinical immunology : (Orlando, Fla. Print) [ 1521-6616 ] ; 2006.

RBID : Pascal:06-0407325

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Cellule effectrice, Lymphocyte T, Protéine S, Réponse immune, Coronavirus, Interféron gamma, Antigène, Homme, Immunité cellulaire, Lymphocyte mémoire.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antigen, Cellular immunity, Coronavirus, Effectory cell, Gamma interferon, Human, Immune response, Memory lymphocyte, Protein S, Severe acute respiratory syndrome, T-Lymphocyte.

Abstract

The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4⁺ and CD8⁺ T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4⁺ Tcells were central memory cells expressing CD45RO⁺ CCR7⁺ CD62L-. However, the majority of memory CD8⁺ T cells revealed effector memory phenotype expressing CD45RO^- CCR7^- CD62L-. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.

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A08	`01`	`1`	`ENG`	`@1 Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients`
A11	`01`	`1`		`@1 YANG (Li-Tao)`
A11	`02`	`1`		`@1 HUI PONG`
A11	`03`	`1`		`@1 ZHU (Zhao-Ling)`
A11	`04`	`1`		`@1 GANG LI`
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C01	`01`		`ENG`	@0 The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4⁺ and CD8⁺ T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4⁺ Tcells were central memory cells expressing CD45RO⁺ CCR7⁺ CD62L-. However, the majority of memory CD8⁺ T cells revealed effector memory phenotype expressing CD45RO^- CCR7^- CD62L-. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.
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C03	`01`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Cellule effectrice @5 02`
C03	`02`	`X`	`ENG`	`@0 Effectory cell @5 02`
C03	`02`	`X`	`SPA`	`@0 Célula efectora @5 02`
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C03	`04`	`X`	`FRE`	`@0 Protéine S @5 04`
C03	`04`	`X`	`ENG`	`@0 Protein S @5 04`
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C03	`07`	`X`	`ENG`	`@0 Gamma interferon @5 07`
C03	`07`	`X`	`SPA`	`@0 Interferón gamma @5 07`
C03	`08`	`X`	`FRE`	`@0 Antigène @5 08`
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C03	`11`	`X`	`FRE`	`@0 Lymphocyte mémoire @4 CD @5 96`
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C07	`04`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`ENG`	`@0 Nidovirales @2 NW`
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C07	`05`	`X`	`FRE`	`@0 Virus @2 NW`
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C07	`09`	`X`	`ENG`	`@0 Lung disease @5 40`
C07	`09`	`X`	`SPA`	`@0 Pulmón patología @5 40`
N21				`@1 268`

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Pascal:06-0407325

Le document en format XML

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<author><name sortKey="Wu, Chang You" sort="Wu, Chang You" uniqKey="Wu C" first="Chang-You" last="Wu">Chang-You Wu</name>
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<author><name sortKey="Bailer, Robert T" sort="Bailer, Robert T" uniqKey="Bailer R" first="Robert T." last="Bailer">Robert T. Bailer</name>
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<author><name sortKey="Wu, Chang You" sort="Wu, Chang You" uniqKey="Wu C" first="Chang-You" last="Wu">Chang-You Wu</name>
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<series><title level="j" type="main">Clinical immunology : (Orlando, Fla. Print)</title>
<title level="j" type="abbreviated">Clin. immunol. : (Orlando, Fla., Print)</title>
<idno type="ISSN">1521-6616</idno>
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<seriesStmt><title level="j" type="main">Clinical immunology : (Orlando, Fla. Print)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigen</term>
<term>Cellular immunity</term>
<term>Coronavirus</term>
<term>Effectory cell</term>
<term>Gamma interferon</term>
<term>Human</term>
<term>Immune response</term>
<term>Memory lymphocyte</term>
<term>Protein S</term>
<term>Severe acute respiratory syndrome</term>
<term>T-Lymphocyte</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
<term>Cellule effectrice</term>
<term>Lymphocyte T</term>
<term>Protéine S</term>
<term>Réponse immune</term>
<term>Coronavirus</term>
<term>Interféron gamma</term>
<term>Antigène</term>
<term>Homme</term>
<term>Immunité cellulaire</term>
<term>Lymphocyte mémoire</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4<sup>+</sup>
 and CD8<sup>+</sup>
 T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4<sup>+</sup>
 Tcells were central memory cells expressing CD45RO<sup>+</sup>
 CCR7<sup>+</sup>
 CD62L-. However, the majority of memory CD8<sup>+</sup>
 T cells revealed effector memory phenotype expressing CD45RO<sup>-</sup>
 CCR7<sup>-</sup>
 CD62L-. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1521-6616</s0>
</fA01>
<fA02 i1="01"><s0>CLIIFY</s0>
</fA02>
<fA03 i2="1"><s0>Clin. immunol. : (Orlando, Fla., Print)</s0>
</fA03>
<fA05><s2>120</s2>
</fA05>
<fA06><s2>2</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>YANG (Li-Tao)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>HUI PONG</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>ZHU (Zhao-Ling)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>GANG LI</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>HUANG (Zi-Tong)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>ZHAO (Zhi-Xin)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KOUP (Richard A.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>BAILER (Robert T.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>WU (Chang-You)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan 2nd Road</s1>
<s2>Guangzhou 510080</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Third affiliated hospital of the Sun Yat-sen University</s1>
<s2>Guangzhou 510630</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Second affiliated hospital of the Sun Yat-sen University</s1>
<s2>Guangzhou 510120</s2>
<s3>CHN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Vaccine Research Center, NIAID/NIH</s1>
<s2>Bethesda, MD 20892</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>171-178</s1>
</fA20>
<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>15461</s2>
<s5>354000133420770070</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>26 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0407325</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Clinical immunology : (Orlando, Fla. Print)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4<sup>+</sup>
 and CD8<sup>+</sup>
 T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4<sup>+</sup>
 Tcells were central memory cells expressing CD45RO<sup>+</sup>
 CCR7<sup>+</sup>
 CD62L-. However, the majority of memory CD8<sup>+</sup>
 T cells revealed effector memory phenotype expressing CD45RO<sup>-</sup>
 CCR7<sup>-</sup>
 CD62L-. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B06</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A06</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Cellule effectrice</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Effectory cell</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Célula efectora</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Lymphocyte T</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>T-Lymphocyte</s0>
<s5>03</s5>
<s6>«T»-Lymphocyte</s6>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Linfocito T</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Protéine S</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Protein S</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Proteína S</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Réponse immune</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Immune response</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Respuesta inmune</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Interféron gamma</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Gamma interferon</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Interferón gamma</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Antigène</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Antigen</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Antígeno</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Homme</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Human</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Immunité cellulaire</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Cellular immunity</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Inmunidad celular</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Lymphocyte mémoire</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Memory lymphocyte</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Immunologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Immunology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Inmunología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Immunopathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Immunopathology</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Inmunopatología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>268</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients

Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients

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