Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients
Identifieur interne : 001540 ( Ncbi/Checkpoint ); précédent : 001539; suivant : 001541Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients
Auteurs : Li-Tao Yang [République populaire de Chine] ; Hui Peng [République populaire de Chine] ; Zhao-Ling Zhu [République populaire de Chine] ; Gang Li [République populaire de Chine] ; Zi-Tong Huang [République populaire de Chine] ; Zhi-Xin Zhao [République populaire de Chine] ; Richard A. Koup [États-Unis] ; Robert T. Bailer [États-Unis] ; Chang-You Wu [République populaire de Chine]Source :
- Clinical Immunology (Orlando, Fla.) [ 1521-6616 ] ; 2006.
Abstract
The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4+ and CD8+ T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4+ T cells were central memory cells expressing CD45RO+ CCR7+ CD62L−. However, the majority of memory CD8+ T cells revealed effector memory phenotype expressing CD45RO− CCR7− CD62L−. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.
Url:
DOI: 10.1016/j.clim.2006.05.002
PubMed: 16781892
PubMed Central: 7106132
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4<sup>+</sup>
and CD8<sup>+</sup>
T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4<sup>+</sup>
T cells were central memory cells expressing CD45RO<sup>+</sup>
CCR7<sup>+</sup>
CD62L<sup>−</sup>
. However, the majority of memory CD8<sup>+</sup>
T cells revealed effector memory phenotype expressing CD45RO<sup>−</sup>
CCR7<sup>−</sup>
CD62L<sup>−</sup>
. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.</p>
</div>
</front>
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<li>États-Unis</li>
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<region><li>Guangdong</li>
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<name sortKey="Zhao, Zhi Xin" sort="Zhao, Zhi Xin" uniqKey="Zhao Z" first="Zhi-Xin" last="Zhao">Zhi-Xin Zhao</name>
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