Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients
Identifieur interne : 001540 ( Ncbi/Checkpoint ); précédent : 001539; suivant : 001541Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients
Auteurs : Li-Tao Yang [République populaire de Chine] ; Hui Peng [République populaire de Chine] ; Zhao-Ling Zhu [République populaire de Chine] ; Gang Li [République populaire de Chine] ; Zi-Tong Huang [République populaire de Chine] ; Zhi-Xin Zhao [République populaire de Chine] ; Richard A. Koup [États-Unis] ; Robert T. Bailer [États-Unis] ; Chang-You Wu [République populaire de Chine]Source :
- Clinical Immunology (Orlando, Fla.) [ 1521-6616 ] ; 2006.
Abstract
The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4+ and CD8+ T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4+ T cells were central memory cells expressing CD45RO+ CCR7+ CD62L−. However, the majority of memory CD8+ T cells revealed effector memory phenotype expressing CD45RO− CCR7− CD62L−. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.
Url:
DOI: 10.1016/j.clim.2006.05.002
PubMed: 16781892
PubMed Central: 7106132
Affiliations:
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Koup</name><affiliation wicri:level="2"><nlm:aff id="aff4">Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bailer, Robert T" sort="Bailer, Robert T" uniqKey="Bailer R" first="Robert T." last="Bailer">Robert T. Bailer</name><affiliation wicri:level="2"><nlm:aff id="aff4">Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wu, Chang You" sort="Wu, Chang You" uniqKey="Wu C" first="Chang-You" last="Wu">Chang-You Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou 510080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou 510080</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">Clinical Immunology (Orlando, Fla.)</title><idno type="ISSN">1521-6616</idno><idno type="eISSN">1521-7035</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4<sup>+</sup> and CD8<sup>+</sup> T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4<sup>+</sup> T cells were central memory cells expressing CD45RO<sup>+</sup> CCR7<sup>+</sup> CD62L<sup>−</sup>. However, the majority of memory CD8<sup>+</sup> T cells revealed effector memory phenotype expressing CD45RO<sup>−</sup> CCR7<sup>−</sup> CD62L<sup>−</sup>. Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, J S M" uniqKey="Peiris J">J.S.M. Peiris</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Poon, L L M" uniqKey="Poon L">L.L.M. Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yam, L Y C" uniqKey="Yam L">L.Y.C. Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J. Nicholls</name></author><author><name sortKey="Yee, W K S" uniqKey="Yee W">W.K.S. Yee</name></author><author><name sortKey="Yan, W W" uniqKey="Yan W">W.W. Yan</name></author><author><name sortKey="Cheung, M T" uniqKey="Cheung M">M.T. Cheung</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tsang, D N C" uniqKey="Tsang D">D.N.C. Tsang</name></author><author><name sortKey="Yung, R W H" uniqKey="Yung R">R.W.H. Yung</name></author><author><name sortKey="Ng, T K" uniqKey="Ng T">T.K. Ng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Günther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Werf, S" uniqKey="Werf S">S. Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name></author><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R.A.M. Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name></author><author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguiere</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name></author><author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S. Müller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Stürmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S M" uniqKey="Peiris J">J.S.M. Peiris</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K. Stöhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z.Y. Yang</name></author><author><name sortKey="Kong, W P" uniqKey="Kong W">W.P. Kong</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bisht, H" uniqKey="Bisht H">H. Bisht</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Bukreyev, A" uniqKey="Bukreyev A">A. Bukreyev</name></author><author><name sortKey="Collins, P L" uniqKey="Collins P">P.L. Collins</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Moss, B" uniqKey="Moss B">B. Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bukreyev, A" uniqKey="Bukreyev A">A. Bukreyev</name></author><author><name sortKey="Lamirande, E W" uniqKey="Lamirande E">E.W. Lamirande</name></author><author><name sortKey="Buchholz, U J" uniqKey="Buchholz U">U.J. Buchholz</name></author><author><name sortKey="Vogel, L N" uniqKey="Vogel L">L.N. Vogel</name></author><author><name sortKey="Elkins, W R" uniqKey="Elkins W">W.R. Elkins</name></author><author><name sortKey="Claire, M S" uniqKey="Claire M">M.S. Claire</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Collins, P L" uniqKey="Collins P">P.L. Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchholz, U J" uniqKey="Buchholz U">U.J. Buchholz</name></author><author><name sortKey="Bukreyev, A" uniqKey="Bukreyev A">A. Bukreyev</name></author><author><name sortKey="Yang, L J" uniqKey="Yang L">L.J. Yang</name></author><author><name sortKey="Lamirande, E W" uniqKey="Lamirande E">E.W. Lamirande</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Collins, P L" uniqKey="Collins P">P.L. Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, W T" uniqKey="Gao W">W.T. Gao</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name></author><author><name sortKey="Soloff, A" uniqKey="Soloff A">A. Soloff</name></author><author><name sortKey="D Aluto, L" uniqKey="D Aluto L">L. D'Aluto</name></author><author><name sortKey="Nwanegbo, E" uniqKey="Nwanegbo E">E. Nwanegbo</name></author><author><name sortKey="Robbins, P D" uniqKey="Robbins P">P.D. Robbins</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author><author><name sortKey="Barratt Boyes, S" uniqKey="Barratt Boyes S">S. Barratt-Boyes</name></author><author><name sortKey="Gambotto, A" uniqKey="Gambotto A">A. Gambotto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G. Li</name></author><author><name sortKey="Chen, X J" uniqKey="Chen X">X.J. Chen</name></author><author><name sortKey="Xu, A L" uniqKey="Xu A">A.L. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y D" uniqKey="Wang Y">Y.D. Wang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Xu, G B" uniqKey="Xu G">G.B. Xu</name></author><author><name sortKey="Dong, X Y" uniqKey="Dong X">X.Y. Dong</name></author><author><name sortKey="Yang, X A" uniqKey="Yang X">X.A. Yang</name></author><author><name sortKey="Feng, Z R" uniqKey="Feng Z">Z.R. Feng</name></author><author><name sortKey="Tian, C" uniqKey="Tian C">C. Tian</name></author><author><name sortKey="Chen, W F" uniqKey="Chen W">W.F. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soo, Y O Y" uniqKey="Soo Y">Y.O.Y. Soo</name></author><author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y. Cheng</name></author><author><name sortKey="Wong, R" uniqKey="Wong R">R. Wong</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Lee, C K" uniqKey="Lee C">C.K. Lee</name></author><author><name sortKey="Tsang, K K S" uniqKey="Tsang K">K.K.S. Tsang</name></author><author><name sortKey="Ng, M H L" uniqKey="Ng M">M.H.L. Ng</name></author><author><name sortKey="Chan, P" uniqKey="Chan P">P. Chan</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G. Cheng</name></author><author><name sortKey="Sung, J J Y" uniqKey="Sung J">J.J.Y. Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhi, Y" uniqKey="Zhi Y">Y. Zhi</name></author><author><name sortKey="Kobinger, G P" uniqKey="Kobinger G">G.P. Kobinger</name></author><author><name sortKey="Jordan, H" uniqKey="Jordan H">H. Jordan</name></author><author><name sortKey="Suchma, K" uniqKey="Suchma K">K. Suchma</name></author><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S.R. Weiss</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name></author><author><name sortKey="Schumer, G" uniqKey="Schumer G">G. Schumer</name></author><author><name sortKey="Gao, G P" uniqKey="Gao G">G.P. Gao</name></author><author><name sortKey="Boyer, J L" uniqKey="Boyer J">J.L. Boyer</name></author><author><name sortKey="Crystal, R G" uniqKey="Crystal R">R.G. Crystal</name></author><author><name sortKey="Wilson, J M" uniqKey="Wilson J">J.M. Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y D" uniqKey="Wang Y">Y.D. Wang</name></author><author><name sortKey="Chen, W F" uniqKey="Chen W">W.F. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y D" uniqKey="Wang Y">Y.D. Wang</name></author><author><name sortKey="Fion Sin, W Y" uniqKey="Fion Sin W">W.Y. Fion Sin</name></author><author><name sortKey="Xu, G B" uniqKey="Xu G">G.B. Xu</name></author><author><name sortKey="Yang, H H" uniqKey="Yang H">H.H. Yang</name></author><author><name sortKey="Wong, T Y" uniqKey="Wong T">T.Y. Wong</name></author><author><name sortKey="Pang, X W" uniqKey="Pang X">X.W. Pang</name></author><author><name sortKey="He, X Y" uniqKey="He X">X.Y. He</name></author><author><name sortKey="Zhang, H G" uniqKey="Zhang H">H.G. Zhang</name></author><author><name sortKey="Ng, J N L" uniqKey="Ng J">J.N.L. Ng</name></author><author><name sortKey="Cheng, C S S" uniqKey="Cheng C">C.S.S. Cheng</name></author><author><name sortKey="Ju, J" uniqKey="Ju J">J. Ju</name></author><author><name sortKey="Meng, L" uniqKey="Meng L">L. Meng</name></author><author><name sortKey="Yang, R F" uniqKey="Yang R">R.F. Yang</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Guo, Z H" uniqKey="Guo Z">Z.H. Guo</name></author><author><name sortKey="Xie, Y" uniqKey="Xie Y">Y. Xie</name></author><author><name sortKey="Chen, W F" uniqKey="Chen W">W.F. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, B M" uniqKey="Wang B">B.M. Wang</name></author><author><name sortKey="Chen, H B" uniqKey="Chen H">H.B. Chen</name></author><author><name sortKey="Jiang, X D" uniqKey="Jiang X">X.D. Jiang</name></author><author><name sortKey="Zhang, M H" uniqKey="Zhang M">M.H. Zhang</name></author><author><name sortKey="Wan, T" uniqKey="Wan T">T. Wan</name></author><author><name sortKey="Li, N" uniqKey="Li N">N. Li</name></author><author><name sortKey="Zhou, X Y" uniqKey="Zhou X">X.Y. Zhou</name></author><author><name sortKey="Wu, Y F" uniqKey="Wu Y">Y.F. Wu</name></author><author><name sortKey="Yang, F" uniqKey="Yang F">F. Yang</name></author><author><name sortKey="Yu, Y Z" uniqKey="Yu Y">Y.Z. Yu</name></author><author><name sortKey="Wang, X N" uniqKey="Wang X">X.N. Wang</name></author><author><name sortKey="Yang, R F" uniqKey="Yang R">R.F. Yang</name></author><author><name sortKey="Cao, X T" uniqKey="Cao X">X.T. Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abbas, A K" uniqKey="Abbas A">A.K. Abbas</name></author><author><name sortKey="Murphy, K M" uniqKey="Murphy K">K.M. Murphy</name></author><author><name sortKey="Sher, A" uniqKey="Sher A">A. Sher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, C Y" uniqKey="Wu C">C.Y. Wu</name></author><author><name sortKey="Kirman, J R" uniqKey="Kirman J">J.R. Kirman</name></author><author><name sortKey="Rotte, M J" uniqKey="Rotte M">M.J. Rotte</name></author><author><name sortKey="Davey, D F" uniqKey="Davey D">D.F. Davey</name></author><author><name sortKey="Perfetto, S P" uniqKey="Perfetto S">S.P. Perfetto</name></author><author><name sortKey="Rhee, E G" uniqKey="Rhee E">E.G. Rhee</name></author><author><name sortKey="Freidag, B L" uniqKey="Freidag B">B.L. Freidag</name></author><author><name sortKey="Hill, B J" uniqKey="Hill B">B.J. Hill</name></author><author><name sortKey="Douek, D C" uniqKey="Douek D">D.C. Douek</name></author><author><name sortKey="Seder, R A" uniqKey="Seder R">R.A. Seder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, H B" uniqKey="Chen H">H.B. Chen</name></author><author><name sortKey="Hou, J L" uniqKey="Hou J">J.L. Hou</name></author><author><name sortKey="Jiang, X D" uniqKey="Jiang X">X.D. Jiang</name></author><author><name sortKey="Ma, S W" uniqKey="Ma S">S.W. Ma</name></author><author><name sortKey="Meng, M J" uniqKey="Meng M">M.J. Meng</name></author><author><name sortKey="Wang, B M" uniqKey="Wang B">B.M. Wang</name></author><author><name sortKey="Zhang, M H" uniqKey="Zhang M">M.H. Zhang</name></author><author><name sortKey="Zhang, M X" uniqKey="Zhang M">M.X. Zhang</name></author><author><name sortKey="Tang, X P" uniqKey="Tang X">X.P. Tang</name></author><author><name sortKey="Zhang, F C" uniqKey="Zhang F">F.C. Zhang</name></author><author><name sortKey="Wan, T" uniqKey="Wan T">T. Wan</name></author><author><name sortKey="Li, N" uniqKey="Li N">N. Li</name></author><author><name sortKey="Yu, Y Z" uniqKey="Yu Y">Y.Z. Yu</name></author><author><name sortKey="Hu, H B" uniqKey="Hu H">H.B. Hu</name></author><author><name sortKey="Yang, R F" uniqKey="Yang R">R.F. Yang</name></author><author><name sortKey="He, W" uniqKey="He W">W. He</name></author><author><name sortKey="Wang, X N" uniqKey="Wang X">X.N. Wang</name></author><author><name sortKey="Cao, X T" uniqKey="Cao X">X.T. Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wherry, E J" uniqKey="Wherry E">E.J. Wherry</name></author><author><name sortKey="Teichgr Ber, V" uniqKey="Teichgr Ber V">V. Teichgräber</name></author><author><name sortKey="Becker, T C" uniqKey="Becker T">T.C. Becker</name></author><author><name sortKey="Masopust, D" uniqKey="Masopust D">D. Masopust</name></author><author><name sortKey="Kaech, S M" uniqKey="Kaech S">S.M. Kaech</name></author><author><name sortKey="Antia, R" uniqKey="Antia R">R. Antia</name></author><author><name sortKey="Von Andrian, U H" uniqKey="Von Andrian U">U.H. von Andrian</name></author><author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R. Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sallusto, F" uniqKey="Sallusto F">F. Sallusto</name></author><author><name sortKey="Lenig, D" uniqKey="Lenig D">D. Lenig</name></author><author><name sortKey="Forster, R" uniqKey="Forster R">R. Förster</name></author><author><name sortKey="Lipp, M" uniqKey="Lipp M">M. Lipp</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A. Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debes, G F" uniqKey="Debes G">G.F. Debes</name></author><author><name sortKey="Bonhagen, K" uniqKey="Bonhagen K">K. Bonhagen</name></author><author><name sortKey="Wolff, T" uniqKey="Wolff T">T. Wolff</name></author><author><name sortKey="Kretschmer, U" uniqKey="Kretschmer U">U. Kretschmer</name></author><author><name sortKey="Krautwald, S" uniqKey="Krautwald S">S. Krautwald</name></author><author><name sortKey="Kamradt, T" uniqKey="Kamradt T">T. Kamradt</name></author><author><name sortKey="Hamann, A" uniqKey="Hamann A">A. Hamann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Unsoeld, H" uniqKey="Unsoeld H">H. Unsoeld</name></author><author><name sortKey="Pircher, H" uniqKey="Pircher H">H. Pircher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Unsoeld, H" uniqKey="Unsoeld H">H. Unsoeld</name></author><author><name sortKey="Krautwald, S" uniqKey="Krautwald S">S. Krautwald</name></author><author><name sortKey="Voehringer, D" uniqKey="Voehringer D">D. Voehringer</name></author><author><name sortKey="Kunzendorf, U" uniqKey="Kunzendorf U">U. Kunzendorf</name></author><author><name sortKey="Pircher, H" uniqKey="Pircher H">H. Pircher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimmerli, S C" uniqKey="Zimmerli S">S.C. Zimmerli</name></author><author><name sortKey="Harari, A" uniqKey="Harari A">A. Harari</name></author><author><name sortKey="Cellerai, C" uniqKey="Cellerai C">C. Cellerai</name></author><author><name sortKey="Vallelian, F" uniqKey="Vallelian F">F. Vallelian</name></author><author><name sortKey="Bart, P A" uniqKey="Bart P">P.A. Bart</name></author><author><name sortKey="Pantaleo, G" uniqKey="Pantaleo G">G. Pantaleo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Champagne, P" uniqKey="Champagne P">P. Champagne</name></author><author><name sortKey="Ogg, G S" uniqKey="Ogg G">G.S. Ogg</name></author><author><name sortKey="King, A S" uniqKey="King A">A.S. King</name></author><author><name sortKey="Knabenhans, C" uniqKey="Knabenhans C">C. Knabenhans</name></author><author><name sortKey="Ellefsen, K" uniqKey="Ellefsen K">K. Ellefsen</name></author><author><name sortKey="Nobile, M" uniqKey="Nobile M">M. Nobile</name></author><author><name sortKey="Appay, V" uniqKey="Appay V">V. Appay</name></author><author><name sortKey="Rizzardi, G P" uniqKey="Rizzardi G">G.P. Rizzardi</name></author><author><name sortKey="Fleury, S" uniqKey="Fleury S">S. Fleury</name></author><author><name sortKey="Lipp, M" uniqKey="Lipp M">M. Lipp</name></author><author><name sortKey="Forster, R" uniqKey="Forster R">R. Förster</name></author><author><name sortKey="Rowland Jones, S" uniqKey="Rowland Jones S">S. Rowland-Jones</name></author><author><name sortKey="Sekaly, R P" uniqKey="Sekaly R">R.P. Sekaly</name></author><author><name sortKey="Mcmichael, A J" uniqKey="Mcmichael A">A.J. McMichael</name></author><author><name sortKey="Pantaleo, G" uniqKey="Pantaleo G">G. Pantaleo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seder, R A" uniqKey="Seder R">R.A. Seder</name></author><author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R. Ahmed</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Guangdong</li><li>Maryland</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Yang, Li Tao" sort="Yang, Li Tao" uniqKey="Yang L" first="Li-Tao" last="Yang">Li-Tao Yang</name></region><name sortKey="Huang, Zi Tong" sort="Huang, Zi Tong" uniqKey="Huang Z" first="Zi-Tong" last="Huang">Zi-Tong Huang</name><name sortKey="Li, Gang" sort="Li, Gang" uniqKey="Li G" first="Gang" last="Li">Gang Li</name><name sortKey="Peng, Hui" sort="Peng, Hui" uniqKey="Peng H" first="Hui" last="Peng">Hui Peng</name><name sortKey="Wu, Chang You" sort="Wu, Chang You" uniqKey="Wu C" first="Chang-You" last="Wu">Chang-You Wu</name><name sortKey="Zhao, Zhi Xin" sort="Zhao, Zhi Xin" uniqKey="Zhao Z" first="Zhi-Xin" last="Zhao">Zhi-Xin Zhao</name><name sortKey="Zhu, Zhao Ling" sort="Zhu, Zhao Ling" uniqKey="Zhu Z" first="Zhao-Ling" last="Zhu">Zhao-Ling Zhu</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Koup, Richard A" sort="Koup, Richard A" uniqKey="Koup R" first="Richard A." last="Koup">Richard A. Koup</name></region><name sortKey="Bailer, Robert T" sort="Bailer, Robert T" uniqKey="Bailer R" first="Robert T." last="Bailer">Robert T. Bailer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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