Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons
Identifieur interne : 005B18 ( Main/Exploration ); précédent : 005B17; suivant : 005B19Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons
Auteurs : Carolina Scagnolari [Italie] ; Elisa Vicenzi [Italie] ; Francesca Bellomi [Italie] ; Maria Giuseppina Stillitano [Italie] ; Debora Pinna [Italie] ; Guido Poli [Italie] ; Massimo Clementi [Italie] ; Ferdinando Dianzani [Italie] ; Guido Antonelli [Italie]Source :
- Antiviral therapy : (London) [ 1359-6535 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Cellules Vero, Humains, Interféron de type I (génétique), Interféron de type I (pharmacologie), Interféron gamma (génétique), Interféron gamma (pharmacologie), Protéines G (génétique), Protéines G (métabolisme), Protéines de résistance aux myxovirus, Protéines recombinantes (pharmacologie), Réplication virale (), Synergie des médicaments, Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- génétique : Interféron de type I, Interféron gamma, Protéines G.
- métabolisme : Protéines G.
- pharmacologie : Interféron de type I, Interféron gamma, Protéines recombinantes.
- physiologie : Virus du SRAS.
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Cytokine, Drug Synergism, GTP-Binding Proteins (genetics), GTP-Binding Proteins (metabolism), Human, Humans, Interferon, Interferon Type I (genetics), Interferon Type I (pharmacology), Interferon-gamma (genetics), Interferon-gamma (pharmacology), Myxovirus Resistance Proteins, Recombinant Proteins (pharmacology), SARS Virus (drug effects), SARS Virus (physiology), Sensitivity, Severe acute respiratory syndrome virus, Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , genetics : GTP-Binding Proteins, Interferon Type I, Interferon-gamma.
- chemical , metabolism : GTP-Binding Proteins.
- chemical , pharmacology : Interferon Type I, Interferon-gamma, Recombinant Proteins.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Drug Synergism, Humans, Myxovirus Resistance Proteins, Vero Cells.
Abstract
There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000738
- to stream PascalFrancis, to step Curation: 000252
- to stream PascalFrancis, to step Checkpoint: 000828
- to stream Main, to step Merge: 005F79
- to stream PubMed, to step Corpus: 002937
- to stream PubMed, to step Curation: 002937
- to stream PubMed, to step Checkpoint: 002C40
- to stream Ncbi, to step Merge: 000D30
- to stream Ncbi, to step Curation: 000D30
- to stream Ncbi, to step Checkpoint: 000D30
- to stream Main, to step Merge: 005694
- to stream Main, to step Curation: 005B18
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons</title>
<author><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>School of Medicine, Vita-Salute University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Università 'Campus Biomedico'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0076971</idno>
<date when="2004">2004</date>
<idno type="stanalyst">PASCAL 05-0076971 INIST</idno>
<idno type="RBID">Pascal:05-0076971</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000738</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000252</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000828</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000828</idno>
<idno type="wicri:doubleKey">1359-6535:2004:Scagnolari C:increased:sensitivity:of</idno>
<idno type="wicri:Area/Main/Merge">005F79</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:15651759</idno>
<idno type="wicri:Area/PubMed/Corpus">002937</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002937</idno>
<idno type="wicri:Area/PubMed/Curation">002937</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002937</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002C40</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002C40</idno>
<idno type="wicri:Area/Ncbi/Merge">000D30</idno>
<idno type="wicri:Area/Ncbi/Curation">000D30</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D30</idno>
<idno type="wicri:doubleKey">1359-6535:2004:Scagnolari C:increased:sensitivity:of</idno>
<idno type="wicri:Area/Main/Merge">005694</idno>
<idno type="wicri:Area/Main/Curation">005B18</idno>
<idno type="wicri:Area/Main/Exploration">005B18</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons</title>
<author><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>School of Medicine, Vita-Salute University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Università 'Campus Biomedico'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Antiviral therapy : (London)</title>
<title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title>
<idno type="ISSN">1359-6535</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Antiviral therapy : (London)</title>
<title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title>
<idno type="ISSN">1359-6535</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Chlorocebus aethiops</term>
<term>Cytokine</term>
<term>Drug Synergism</term>
<term>GTP-Binding Proteins (genetics)</term>
<term>GTP-Binding Proteins (metabolism)</term>
<term>Human</term>
<term>Humans</term>
<term>Interferon</term>
<term>Interferon Type I (genetics)</term>
<term>Interferon Type I (pharmacology)</term>
<term>Interferon-gamma (genetics)</term>
<term>Interferon-gamma (pharmacology)</term>
<term>Myxovirus Resistance Proteins</term>
<term>Recombinant Proteins (pharmacology)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
<term>Sensitivity</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Vero Cells</term>
<term>Virus Replication (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Humains</term>
<term>Interféron de type I (génétique)</term>
<term>Interféron de type I (pharmacologie)</term>
<term>Interféron gamma (génétique)</term>
<term>Interféron gamma (pharmacologie)</term>
<term>Protéines G (génétique)</term>
<term>Protéines G (métabolisme)</term>
<term>Protéines de résistance aux myxovirus</term>
<term>Protéines recombinantes (pharmacologie)</term>
<term>Réplication virale ()</term>
<term>Synergie des médicaments</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>GTP-Binding Proteins</term>
<term>Interferon Type I</term>
<term>Interferon-gamma</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>GTP-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Interferon Type I</term>
<term>Interferon-gamma</term>
<term>Recombinant Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Interféron de type I</term>
<term>Interféron gamma</term>
<term>Protéines G</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines G</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Interféron de type I</term>
<term>Interféron gamma</term>
<term>Protéines recombinantes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chlorocebus aethiops</term>
<term>Drug Synergism</term>
<term>Humans</term>
<term>Myxovirus Resistance Proteins</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Humains</term>
<term>Protéines de résistance aux myxovirus</term>
<term>Réplication virale</term>
<term>Sensibilité</term>
<term>Synergie des médicaments</term>
<term>Virus du SRAS</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Homme</term>
<term>Cytokine</term>
<term>Interféron</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Latium</li>
<li>Lombardie</li>
</region>
<settlement><li>Milan</li>
<li>Rome</li>
</settlement>
</list>
<tree><country name="Italie"><region name="Latium"><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
</region>
<name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
<name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name>
<name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name>
<name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name>
<name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name>
<name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005B18 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005B18 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:05-0076971 |texte= Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons }}
This area was generated with Dilib version V0.6.33. |