SrasV1, PascalFrancis, Curation, bibRecord, 000252

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Identifieur interne : 000252 ( PascalFrancis/Curation ); précédent : 000251; suivant : 000253

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Auteurs : Carolina Scagnolari [Italie] ; Elisa Vicenzi [Italie] ; Francesca Bellomi [Italie] ; Maria Giuseppina Stillitano [Italie] ; Debora Pinna [Italie] ; Guido Poli [Italie] ; Massimo Clementi [Italie] ; Ferdinando Dianzani [Italie] ; Guido Antonelli [Italie]

Source :

Antiviral therapy : (London) [ 1359-6535 ] ; 2004.

RBID : Pascal:05-0076971

Descripteurs français

Pascal (Inist)
- Sensibilité, Virus syndrome respiratoire aigu sévère, Homme, Cytokine, Interféron.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cytokine, Human, Interferon, Sensitivity, Severe acute respiratory syndrome virus.

Abstract

There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.

A01	`01`	`1`		`@0 1359-6535`
A03		`1`		`@0 Antivir. ther. : (Lond.)`
A05				`@2 9`
A06				`@2 6`
A08	`01`	`1`	`ENG`	`@1 Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons`
A11	`01`	`1`		`@1 SCAGNOLARI (Carolina)`
A11	`02`	`1`		`@1 VICENZI (Elisa)`
A11	`03`	`1`		`@1 BELLOMI (Francesca)`
A11	`04`	`1`		`@1 STILLITANO (Maria Giuseppina)`
A11	`05`	`1`		`@1 PINNA (Debora)`
A11	`06`	`1`		`@1 POLI (Guido)`
A11	`07`	`1`		`@1 CLEMENTI (Massimo)`
A11	`08`	`1`		`@1 DIANZANI (Ferdinando)`
A11	`09`	`1`		`@1 ANTONELLI (Guido)`
A14	`01`			`@1 Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza' @2 Rome @3 ITA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 9 aut.`
A14	`02`			`@1 AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute @2 Milan @3 ITA @Z 2 aut. @Z 5 aut. @Z 6 aut.`
A14	`03`			`@1 Microbiology and Virology Laboratory, San Raffaele Scientific Institute @2 Milan @3 ITA @Z 6 aut. @Z 7 aut.`
A14	`04`			`@1 School of Medicine, Vita-Salute University @2 Milan @3 ITA @Z 7 aut.`
A14	`05`			`@1 Università 'Campus Biomedico' @2 Rome @3 ITA @Z 8 aut.`
A20				`@1 1003-1011`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 27047 @5 354000126038180170`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 38 ref.`
A47	`01`	`1`		`@0 05-0076971`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Antiviral therapy : (London)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Sensibilité @5 11`
C03	`01`	`X`	`ENG`	`@0 Sensitivity @5 11`
C03	`01`	`X`	`SPA`	`@0 Sensibilidad @5 11`
C03	`02`	`X`	`FRE`	`@0 Virus syndrome respiratoire aigu sévère @2 NW @5 12`
C03	`02`	`X`	`ENG`	`@0 Severe acute respiratory syndrome virus @2 NW @5 12`
C03	`02`	`X`	`SPA`	`@0 Severe acute respiratory syndrome virus @2 NW @5 12`
C03	`03`	`X`	`FRE`	`@0 Homme @5 14`
C03	`03`	`X`	`ENG`	`@0 Human @5 14`
C03	`03`	`X`	`SPA`	`@0 Hombre @5 14`
C03	`04`	`X`	`FRE`	`@0 Cytokine @5 15`
C03	`04`	`X`	`ENG`	`@0 Cytokine @5 15`
C03	`04`	`X`	`SPA`	`@0 Citoquina @5 15`
C03	`05`	`X`	`FRE`	`@0 Interféron @2 NK @2 FR @5 16`
C03	`05`	`X`	`ENG`	`@0 Interferon @2 NK @2 FR @5 16`
C03	`05`	`X`	`SPA`	`@0 Interferón @2 NK @2 FR @5 16`
C07	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`04`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`04`	`X`	`SPA`	`@0 Virus @2 NW`
N21				`@1 045`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000738

Links to Exploration step

Pascal:05-0076971

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons</title>
<author><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>School of Medicine, Vita-Salute University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Università 'Campus Biomedico'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0076971</idno>
<date when="2004">2004</date>
<idno type="stanalyst">PASCAL 05-0076971 INIST</idno>
<idno type="RBID">Pascal:05-0076971</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000738</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000252</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons</title>
<author><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>School of Medicine, Vita-Salute University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Università 'Campus Biomedico'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Antiviral therapy : (London)</title>
<title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title>
<idno type="ISSN">1359-6535</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Antiviral therapy : (London)</title>
<title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title>
<idno type="ISSN">1359-6535</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytokine</term>
<term>Human</term>
<term>Interferon</term>
<term>Sensitivity</term>
<term>Severe acute respiratory syndrome virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Sensibilité</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Homme</term>
<term>Cytokine</term>
<term>Interféron</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1359-6535</s0>
</fA01>
<fA03 i2="1"><s0>Antivir. ther. : (Lond.)</s0>
</fA03>
<fA05><s2>9</s2>
</fA05>
<fA06><s2>6</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>SCAGNOLARI (Carolina)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>VICENZI (Elisa)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BELLOMI (Francesca)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>STILLITANO (Maria Giuseppina)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>PINNA (Debora)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>POLI (Guido)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>CLEMENTI (Massimo)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>DIANZANI (Ferdinando)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>ANTONELLI (Guido)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>School of Medicine, Vita-Salute University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Università 'Campus Biomedico'</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>1003-1011</s1>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>27047</s2>
<s5>354000126038180170</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>38 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>05-0076971</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Antiviral therapy : (London)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Sensibilité</s0>
<s5>11</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Sensitivity</s0>
<s5>11</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sensibilidad</s0>
<s5>11</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0>
<s2>NW</s2>
<s5>12</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>12</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>12</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Homme</s0>
<s5>14</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Human</s0>
<s5>14</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Hombre</s0>
<s5>14</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Cytokine</s0>
<s5>15</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Cytokine</s0>
<s5>15</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Citoquina</s0>
<s5>15</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Interféron</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>16</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Interferon</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>16</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Interferón</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>16</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>045</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PascalFrancis/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000252 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000252 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:05-0076971
   |texte=   Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri