Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons
Identifieur interne : 000828 ( PascalFrancis/Checkpoint ); précédent : 000827; suivant : 000829Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons
Auteurs : Carolina Scagnolari [Italie] ; Elisa Vicenzi [Italie] ; Francesca Bellomi [Italie] ; Maria Giuseppina Stillitano [Italie] ; Debora Pinna [Italie] ; Guido Poli [Italie] ; Massimo Clementi [Italie] ; Ferdinando Dianzani [Italie] ; Guido Antonelli [Italie]Source :
- Antiviral therapy : (London) [ 1359-6535 ] ; 2004.
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- Pascal (Inist)
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- topic : Homme.
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Abstract
There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.
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Virology section, University 'La Sapienza'</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>School of Medicine, Vita-Salute University</s1><s2>Milan</s2><s3>ITA</s3><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Università 'Campus Biomedico'</s1><s2>Rome</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Antiviral therapy : (London)</title><title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title><idno type="ISSN">1359-6535</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Antiviral therapy : (London)</title><title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title><idno type="ISSN">1359-6535</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytokine</term><term>Human</term><term>Interferon</term><term>Sensitivity</term><term>Severe acute respiratory syndrome virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Sensibilité</term><term>Virus syndrome respiratoire aigu sévère</term><term>Homme</term><term>Cytokine</term><term>Interféron</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1359-6535</s0></fA01><fA03 i2="1"><s0>Antivir. ther. : (Lond.)</s0></fA03><fA05><s2>9</s2></fA05><fA06><s2>6</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons</s1></fA08><fA11 i1="01" i2="1"><s1>SCAGNOLARI (Carolina)</s1></fA11><fA11 i1="02" i2="1"><s1>VICENZI (Elisa)</s1></fA11><fA11 i1="03" i2="1"><s1>BELLOMI (Francesca)</s1></fA11><fA11 i1="04" i2="1"><s1>STILLITANO (Maria Giuseppina)</s1></fA11><fA11 i1="05" i2="1"><s1>PINNA (Debora)</s1></fA11><fA11 i1="06" i2="1"><s1>POLI (Guido)</s1></fA11><fA11 i1="07" i2="1"><s1>CLEMENTI (Massimo)</s1></fA11><fA11 i1="08" i2="1"><s1>DIANZANI (Ferdinando)</s1></fA11><fA11 i1="09" i2="1"><s1>ANTONELLI (Guido)</s1></fA11><fA14 i1="01"><s1>Department of Exerimental Medicine and Pathology - Virology section, University 'La Sapienza'</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="02"><s1>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="03"><s1>Microbiology and Virology Laboratory, San Raffaele Scientific Institute</s1><s2>Milan</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="04"><s1>School of Medicine, Vita-Salute University</s1><s2>Milan</s2><s3>ITA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="05"><s1>Università 'Campus Biomedico'</s1><s2>Rome</s2><s3>ITA</s3><sZ>8 aut.</sZ></fA14><fA20><s1>1003-1011</s1></fA20><fA21><s1>2004</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>27047</s2><s5>354000126038180170</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>38 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0076971</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Antiviral therapy : (London)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02S05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Sensibilité</s0><s5>11</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Sensitivity</s0><s5>11</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sensibilidad</s0><s5>11</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0><s2>NW</s2><s5>12</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>12</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>12</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Homme</s0><s5>14</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Human</s0><s5>14</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Hombre</s0><s5>14</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Cytokine</s0><s5>15</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Cytokine</s0><s5>15</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Citoquina</s0><s5>15</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Interféron</s0><s2>NK</s2><s2>FR</s2><s5>16</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Interferon</s0><s2>NK</s2><s2>FR</s2><s5>16</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Interferón</s0><s2>NK</s2><s2>FR</s2><s5>16</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fN21><s1>045</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Italie</li></country><region><li>Latium</li><li>Lombardie</li></region><settlement><li>Milan</li><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name></region><name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name><name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name><name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name><name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name><name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name><name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name><name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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