SrasV1, Main, Merge, bibRecord, 005F79

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Identifieur interne : 005F79 ( Main/Merge ); précédent : 005F78; suivant : 005F80

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Auteurs : Carolina Scagnolari [Italie] ; Elisa Vicenzi [Italie] ; Francesca Bellomi [Italie] ; Maria Giuseppina Stillitano [Italie] ; Debora Pinna [Italie] ; Guido Poli [Italie] ; Massimo Clementi [Italie] ; Ferdinando Dianzani [Italie] ; Guido Antonelli [Italie]

Source :

Antiviral therapy : (London) [ 1359-6535 ] ; 2004.

RBID : Pascal:05-0076971

Descripteurs français

Pascal (Inist)
- Sensibilité, Virus syndrome respiratoire aigu sévère, Homme, Cytokine, Interféron.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cytokine, Human, Interferon, Sensitivity, Severe acute respiratory syndrome virus.

Abstract

There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.

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Le document en format XML

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<author><name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name>
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<series><title level="j" type="main">Antiviral therapy : (London)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytokine</term>
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<front><div type="abstract" xml:lang="en">There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Latium</li>
<li>Lombardie</li>
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<tree><country name="Italie"><region name="Latium"><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
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<name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
<name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name>
<name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name>
<name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name>
<name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name>
<name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name>
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</affiliations>
</record>

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Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

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Descripteurs français

English descriptors

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri