SrasV1, Main, Exploration, bibRecord, 004409

Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

Identifieur interne : 004409 ( Main/Exploration ); précédent : 004408; suivant : 004410

Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

Auteurs : Yue-Qing Li [République populaire de Chine] ; Ze-Lin Li [République populaire de Chine] ; Wei-Jie Zhao [République populaire de Chine] ; Rui-Xing Wen [République populaire de Chine] ; Qing-Wei Meng [République populaire de Chine] ; YI ZENG [République populaire de Chine]

Source :

European journal of medicinal chemistry [ 0223-5234 ] ; 2006.

RBID : Pascal:07-0094916

Descripteurs français

KwdFr :
- Animaux, Cellules Vero, Relation structure-activité, Réplication virale (), Stilbènes (), Stilbènes (pharmacologie), Stilbènes (synthèse chimique), Structure moléculaire, Virus du SRAS (), Virus du SRAS (physiologie).
MESH :
- pharmacologie : Stilbènes.
- physiologie : Virus du SRAS.
- synthèse chimique : Stilbènes.
Pascal (Inist)
- Animaux, Cellules Vero, Relation structure-activité, Réplication virale, Stilbènes, Structure moléculaire, Synthèse chimique, Diphénols, Cycle développement virus, Virus du SRAS, Virus syndrome respiratoire aigu sévère, Relation structure activité, Antiviral, Inhibition, In vitro, Benzène dérivé, Hétérocycle azote, Cycle 6 chaînons, Stilbène-3,3p,5,5p-tétraol, Pyridine-3,4-diol(2-[2,5-dihydroxystyryl]).

English descriptors

KwdEn :
- Animals, Antiviral, Benzene derivatives, Chemical synthesis, Chlorocebus aethiops, Diphenols, In vitro, Inhibition, Molecular Structure, Nitrogen heterocycle, SARS Virus (drug effects), SARS Virus (physiology), Severe acute respiratory syndrome virus, Six membered ring, Stilbenes (chemical synthesis), Stilbenes (chemistry), Stilbenes (pharmacology), Structure activity relation, Structure-Activity Relationship, Vero Cells, Virus Replication (drug effects), Virus replication cycle.
MESH :
- chemical , chemical synthesis : Stilbenes.
- chemical , chemistry : Stilbenes.
- drug effects : SARS Virus, Virus Replication.
- chemical , pharmacology : Stilbenes.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Molecular Structure, Structure-Activity Relationship, Vero Cells.

Abstract

Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (≤ 0.5 mg ml^-1) and no significant cytotoxic effects were observed in vitro.

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antiviral</term>
<term>Benzene derivatives</term>
<term>Chemical synthesis</term>
<term>Chlorocebus aethiops</term>
<term>Diphenols</term>
<term>In vitro</term>
<term>Inhibition</term>
<term>Molecular Structure</term>
<term>Nitrogen heterocycle</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Six membered ring</term>
<term>Stilbenes (chemical synthesis)</term>
<term>Stilbenes (chemistry)</term>
<term>Stilbenes (pharmacology)</term>
<term>Structure activity relation</term>
<term>Structure-Activity Relationship</term>
<term>Vero Cells</term>
<term>Virus Replication (drug effects)</term>
<term>Virus replication cycle</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Relation structure-activité</term>
<term>Réplication virale ()</term>
<term>Stilbènes ()</term>
<term>Stilbènes (pharmacologie)</term>
<term>Stilbènes (synthèse chimique)</term>
<term>Structure moléculaire</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Stilbenes</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Stilbenes</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Stilbènes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Stilbenes</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
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<term>Chlorocebus aethiops</term>
<term>Molecular Structure</term>
<term>Structure-Activity Relationship</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Relation structure-activité</term>
<term>Réplication virale</term>
<term>Stilbènes</term>
<term>Structure moléculaire</term>
<term>Synthèse chimique</term>
<term>Diphénols</term>
<term>Cycle développement virus</term>
<term>Virus du SRAS</term>
<term>Virus syndrome respiratoire aigu sévère</term>
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<term>Inhibition</term>
<term>In vitro</term>
<term>Benzène dérivé</term>
<term>Hétérocycle azote</term>
<term>Cycle 6 chaînons</term>
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<front><div type="abstract" xml:lang="en">Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (≤ 0.5 mg ml<sup>-1</sup>
) and no significant cytotoxic effects were observed in vitro.</div>
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Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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