Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication.
Identifieur interne : 001F67 ( PubMed/Checkpoint ); précédent : 001F66; suivant : 001F68Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication.
Auteurs : Yue-Qing Li [République populaire de Chine] ; Ze-Lin Li ; Wei-Jie Zhao ; Rui-Xing Wen ; Qing-Wei Meng ; Yi ZengSource :
- European journal of medicinal chemistry [ 0223-5234 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Stilbènes.
- physiologie : Virus du SRAS.
- synthèse chimique : Stilbènes.
- Animaux, Cellules Vero, Relation structure-activité, Réplication virale, Stilbènes, Structure moléculaire, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Stilbenes.
- chemical , chemistry : Stilbenes.
- drug effects : SARS Virus, Virus Replication.
- chemical , pharmacology : Stilbenes.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Molecular Structure, Structure-Activity Relationship, Vero Cells.
Abstract
Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (
DOI: 10.1016/j.ejmech.2006.03.024
PubMed: 16875760
DOI: 10.1016/j.ejmech.2006.03.024
PubMed: 16875760
Affiliations:
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pubmed:16875760Le document en format XML
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<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
<term>Stilbenes (chemical synthesis)</term>
<term>Stilbenes (chemistry)</term>
<term>Stilbenes (pharmacology)</term>
<term>Structure-Activity Relationship</term>
<term>Vero Cells</term>
<term>Virus Replication (drug effects)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Relation structure-activité</term>
<term>Réplication virale ()</term>
<term>Stilbènes ()</term>
<term>Stilbènes (pharmacologie)</term>
<term>Stilbènes (synthèse chimique)</term>
<term>Structure moléculaire</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Structure-Activity Relationship</term>
<term>Vero Cells</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Relation structure-activité</term>
<term>Réplication virale</term>
<term>Stilbènes</term>
<term>Structure moléculaire</term>
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<front><div type="abstract" xml:lang="en">Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (</div>
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