SrasV1, PascalFrancis, Corpus, bibRecord, 000414

Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

Identifieur interne : 000414 ( PascalFrancis/Corpus ); précédent : 000413; suivant : 000415

Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

Auteurs : Yue-Qing Li ; Ze-Lin Li ; Wei-Jie Zhao ; Rui-Xing Wen ; Qing-Wei Meng ; YI ZENG

Source :

European journal of medicinal chemistry [ 0223-5234 ] ; 2006.

RBID : Pascal:07-0094916

Descripteurs français

Pascal (Inist)
- Synthèse chimique, Diphénols, Cycle développement virus, Virus syndrome respiratoire aigu sévère, Relation structure activité, Antiviral, Inhibition, In vitro, Benzène dérivé, Hétérocycle azote, Cycle 6 chaînons, Stilbène-3,3p,5,5p-tétraol, Pyridine-3,4-diol(2-[2,5-dihydroxystyryl]).

English descriptors

KwdEn :
- Antiviral, Benzene derivatives, Chemical synthesis, Diphenols, In vitro, Inhibition, Nitrogen heterocycle, Severe acute respiratory syndrome virus, Six membered ring, Structure activity relation, Virus replication cycle.

Abstract

Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (≤ 0.5 mg ml^-1) and no significant cytotoxic effects were observed in vitro.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A05				`@2 41`
A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication`
A11	`01`	`1`		`@1 LI (Yue-Qing)`
A11	`02`	`1`		`@1 LI (Ze-Lin)`
A11	`03`	`1`		`@1 ZHAO (Wei-Jie)`
A11	`04`	`1`		`@1 WEN (Rui-Xing)`
A11	`05`	`1`		`@1 MENG (Qing-Wei)`
A11	`06`	`1`		`@1 YI ZENG`
A14	`01`			`@1 State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, BOX 90 @2 Dalian, Liaoning Province 116012 @3 CHN @Z 1 aut. @Z 3 aut. @Z 5 aut.`
A14	`02`			`@1 College of Life Science and Bioengineering, Beijing University of Technology @2 Beijing 100022 @3 CHN @Z 2 aut. @Z 4 aut. @Z 6 aut.`
A20				`@1 1084-1089`
A21				`@1 2006`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 12640 @5 354000133265420070`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 21 ref.`
A47	`01`	`1`		`@0 07-0094916`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 European journal of medicinal chemistry`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (≤ 0.5 mg ml^-1) and no significant cytotoxic effects were observed in vitro.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Synthèse chimique @5 01`
C03	`01`	`X`	`ENG`	`@0 Chemical synthesis @5 01`
C03	`01`	`X`	`SPA`	`@0 Síntesis química @5 01`
C03	`02`	`X`	`FRE`	`@0 Diphénols @5 02`
C03	`02`	`X`	`ENG`	`@0 Diphenols @5 02`
C03	`02`	`X`	`SPA`	`@0 Difenoles @5 02`
C03	`03`	`X`	`FRE`	`@0 Cycle développement virus @5 03`
C03	`03`	`X`	`ENG`	`@0 Virus replication cycle @5 03`
C03	`03`	`X`	`SPA`	`@0 Ciclo desarrollo virus @5 03`
C03	`04`	`X`	`FRE`	`@0 Virus syndrome respiratoire aigu sévère @2 NW @5 04`
C03	`04`	`X`	`ENG`	`@0 Severe acute respiratory syndrome virus @2 NW @5 04`
C03	`04`	`X`	`SPA`	`@0 Severe acute respiratory syndrome virus @2 NW @5 04`
C03	`05`	`X`	`FRE`	`@0 Relation structure activité @5 05`
C03	`05`	`X`	`ENG`	`@0 Structure activity relation @5 05`
C03	`05`	`X`	`SPA`	`@0 Relación estructura actividad @5 05`
C03	`06`	`X`	`FRE`	`@0 Antiviral @5 06`
C03	`06`	`X`	`ENG`	`@0 Antiviral @5 06`
C03	`06`	`X`	`SPA`	`@0 Antiviral @5 06`
C03	`07`	`X`	`FRE`	`@0 Inhibition @5 07`
C03	`07`	`X`	`ENG`	`@0 Inhibition @5 07`
C03	`07`	`X`	`SPA`	`@0 Inhibición @5 07`
C03	`08`	`X`	`FRE`	`@0 In vitro @5 08`
C03	`08`	`X`	`ENG`	`@0 In vitro @5 08`
C03	`08`	`X`	`SPA`	`@0 In vitro @5 08`
C03	`09`	`X`	`FRE`	`@0 Benzène dérivé @5 09`
C03	`09`	`X`	`ENG`	`@0 Benzene derivatives @5 09`
C03	`09`	`X`	`SPA`	`@0 Benceno derivado @5 09`
C03	`10`	`X`	`FRE`	`@0 Hétérocycle azote @5 10`
C03	`10`	`X`	`ENG`	`@0 Nitrogen heterocycle @5 10`
C03	`10`	`X`	`SPA`	`@0 Heterociclo nitrógeno @5 10`
C03	`11`	`X`	`FRE`	`@0 Cycle 6 chaînons @5 11`
C03	`11`	`X`	`ENG`	`@0 Six membered ring @5 11`
C03	`11`	`X`	`SPA`	`@0 Ciclo 6 eslabones @5 11`
C03	`12`	`X`	`FRE`	`@0 Stilbène-3,3p,5,5p-tétraol @2 NK @2 FR @4 INC @5 76`
C03	`13`	`X`	`FRE`	`@0 Pyridine-3,4-diol(2-[2,5-dihydroxystyryl]) @2 NK @2 FR @4 INC @5 77`
C07	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`04`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`04`	`X`	`SPA`	`@0 Virus @2 NW`
N21				`@1 064`

Format Inist (serveur)

NO :	PASCAL 07-0094916 INIST
ET :	Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
AU :	LI (Yue-Qing); LI (Ze-Lin); ZHAO (Wei-Jie); WEN (Rui-Xing); MENG (Qing-Wei); YI ZENG
AF :	State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, BOX 90/Dalian, Liaoning Province 116012/Chine (1 aut., 3 aut., 5 aut.); College of Life Science and Bioengineering, Beijing University of Technology/Beijing 100022/Chine (2 aut., 4 aut., 6 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	European journal of medicinal chemistry; ISSN 0223-5234; Coden EJMCA5; Royaume-Uni; Da. 2006; Vol. 41; No. 9; Pp. 1084-1089; Bibl. 21 ref.
LA :	Anglais
EA :	Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (≤ 0.5 mg ml^-1) and no significant cytotoxic effects were observed in vitro.
CC :	002B02S05
FD :	Synthèse chimique; Diphénols; Cycle développement virus; Virus syndrome respiratoire aigu sévère; Relation structure activité; Antiviral; Inhibition; In vitro; Benzène dérivé; Hétérocycle azote; Cycle 6 chaînons; Stilbène-3,3p,5,5p-tétraol; Pyridine-3,4-diol(2-[2,5-dihydroxystyryl])
FG :	Coronavirus; Coronaviridae; Nidovirales; Virus
ED :	Chemical synthesis; Diphenols; Virus replication cycle; Severe acute respiratory syndrome virus; Structure activity relation; Antiviral; Inhibition; In vitro; Benzene derivatives; Nitrogen heterocycle; Six membered ring
EG :	Coronavirus; Coronaviridae; Nidovirales; Virus
SD :	Síntesis química; Difenoles; Ciclo desarrollo virus; Severe acute respiratory syndrome virus; Relación estructura actividad; Antiviral; Inhibición; In vitro; Benceno derivado; Heterociclo nitrógeno; Ciclo 6 eslabones
LO :	INIST-12640.354000133265420070
ID :	07-0094916

Links to Exploration step

Pascal:07-0094916

Le document en format XML

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<front><div type="abstract" xml:lang="en">Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (≤ 0.5 mg ml<sup>-1</sup>
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<fC01 i1="01" l="ENG"><s0>Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (≤ 0.5 mg ml<sup>-1</sup>
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<s5>04</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Relation structure activité</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Structure activity relation</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Relación estructura actividad</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Inhibition</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Inhibition</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Inhibición</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Benzène dérivé</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Benzene derivatives</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Benceno derivado</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Hétérocycle azote</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Nitrogen heterocycle</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Heterociclo nitrógeno</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Cycle 6 chaînons</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Six membered ring</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Ciclo 6 eslabones</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Stilbène-3,3p,5,5p-tétraol</s0>
<s2>NK</s2>
<s2>FR</s2>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Pyridine-3,4-diol(2-[2,5-dihydroxystyryl])</s0>
<s2>NK</s2>
<s2>FR</s2>
<s4>INC</s4>
<s5>77</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>064</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 07-0094916 INIST</NO>
<ET>Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication</ET>
<AU>LI (Yue-Qing); LI (Ze-Lin); ZHAO (Wei-Jie); WEN (Rui-Xing); MENG (Qing-Wei); YI ZENG</AU>
<AF>State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, BOX 90/Dalian, Liaoning Province 116012/Chine (1 aut., 3 aut., 5 aut.); College of Life Science and Bioengineering, Beijing University of Technology/Beijing 100022/Chine (2 aut., 4 aut., 6 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>European journal of medicinal chemistry; ISSN 0223-5234; Coden EJMCA5; Royaume-Uni; Da. 2006; Vol. 41; No. 9; Pp. 1084-1089; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (≤ 0.5 mg ml<sup>-1</sup>
) and no significant cytotoxic effects were observed in vitro.</EA>
<CC>002B02S05</CC>
<FD>Synthèse chimique; Diphénols; Cycle développement virus; Virus syndrome respiratoire aigu sévère; Relation structure activité; Antiviral; Inhibition; In vitro; Benzène dérivé; Hétérocycle azote; Cycle 6 chaînons; Stilbène-3,3p,5,5p-tétraol; Pyridine-3,4-diol(2-[2,5-dihydroxystyryl])</FD>
<FG>Coronavirus; Coronaviridae; Nidovirales; Virus</FG>
<ED>Chemical synthesis; Diphenols; Virus replication cycle; Severe acute respiratory syndrome virus; Structure activity relation; Antiviral; Inhibition; In vitro; Benzene derivatives; Nitrogen heterocycle; Six membered ring</ED>
<EG>Coronavirus; Coronaviridae; Nidovirales; Virus</EG>
<SD>Síntesis química; Difenoles; Ciclo desarrollo virus; Severe acute respiratory syndrome virus; Relación estructura actividad; Antiviral; Inhibición; In vitro; Benceno derivado; Heterociclo nitrógeno; Ciclo 6 eslabones</SD>
<LO>INIST-12640.354000133265420070</LO>
<ID>07-0094916</ID>
</server>
</inist>
</record>

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Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

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