Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease.
Identifieur interne : 000D25 ( Ncbi/Merge ); précédent : 000D24; suivant : 000D26Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease.
Auteurs : Hélène Mollion [France] ; Peter Ford Dominey ; Emmanuel Broussolle ; Jocelyne Ventre-DomineySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Aged, Deep Brain Stimulation (methods), Female, Humans, Male, Memory Disorders (etiology), Memory Disorders (therapy), Memory, Short-Term (physiology), Middle Aged, Motor Activity (physiology), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (therapy), Photic Stimulation (methods), Reaction Time, Subthalamic Nucleus (physiology).
- MESH :
- complications : Parkinson Disease.
- etiology : Memory Disorders.
- methods : Deep Brain Stimulation, Photic Stimulation.
- physiology : Memory, Short-Term, Motor Activity, Subthalamic Nucleus.
- therapy : Memory Disorders, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Reaction Time.
Abstract
Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color-response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age-matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing.
DOI: 10.1002/mds.23769
PubMed: 21611980
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sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Ventre Dominey, Jocelyne" sort="Ventre Dominey, Jocelyne" uniqKey="Ventre Dominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21611980</idno><idno type="pmid">21611980</idno><idno type="doi">10.1002/mds.23769</idno><idno type="wicri:Area/PubMed/Corpus">000949</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000949</idno><idno type="wicri:Area/PubMed/Curation">000909</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000909</idno><idno type="wicri:Area/PubMed/Checkpoint">000909</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000909</idno><idno 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Dominey</name></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Ventre Dominey, Jocelyne" sort="Ventre Dominey, Jocelyne" uniqKey="Ventre Dominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory Disorders (etiology)</term><term>Memory Disorders (therapy)</term><term>Memory, Short-Term (physiology)</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Photic Stimulation (methods)</term><term>Reaction Time</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Photic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory, Short-Term</term><term>Motor Activity</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Memory Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" 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In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color-response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age-matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21611980</PMID><DateCreated><Year>2011</Year><Month>09</Month><Day>20</Day></DateCreated><DateCompleted><Year>2012</Year><Month>01</Month><Day>27</Day></DateCompleted><DateRevised><Year>2011</Year><Month>09</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>11</Issue><PubDate><Year>2011</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2019-25</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23769</ELocationID><Abstract><AbstractText>Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color-response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age-matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. 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