Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease
Identifieur interne : 001942 ( Istex/Corpus ); précédent : 001941; suivant : 001943Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease
Auteurs : Hélène Mollion ; Peter Ford Dominey ; Emmanuel Broussolle ; Jocelyne Ventre-DomineySource :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
English descriptors
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Abstract
Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23769
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title><author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name><affiliation><mods:affiliation>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Dominey, Peter Ford" sort="Dominey, Peter Ford" uniqKey="Dominey P" first="Peter Ford" last="Dominey">Peter Ford Dominey</name><affiliation><mods:affiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</mods:affiliation></affiliation></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><affiliation><mods:affiliation>Neurology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Ventre Ominey, Jocelyne" sort="Ventre Ominey, Jocelyne" uniqKey="Ventre Ominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name><affiliation><mods:affiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM Unit 846‐18, Avenue Doyen Lépine, 69675 Bron, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:346192D8FA7FD958C858317FE5152B218F0891D8</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23769</idno><idno type="url">https://api.istex.fr/document/346192D8FA7FD958C858317FE5152B218F0891D8/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001942</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001942</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title><author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name><affiliation><mods:affiliation>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Dominey, Peter Ford" sort="Dominey, Peter Ford" uniqKey="Dominey P" first="Peter Ford" last="Dominey">Peter Ford Dominey</name><affiliation><mods:affiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</mods:affiliation></affiliation></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><affiliation><mods:affiliation>Neurology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Ventre Ominey, Jocelyne" sort="Ventre Ominey, Jocelyne" uniqKey="Ventre Ominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name><affiliation><mods:affiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM Unit 846‐18, Avenue Doyen Lépine, 69675 Bron, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2019">2019</biblScope><biblScope unit="page" to="2025">2025</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">346192D8FA7FD958C858317FE5152B218F0891D8</idno><idno type="DOI">10.1002/mds.23769</idno><idno type="ArticleID">MDS23769</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>functional dissociation</term><term>motor execution</term><term>subthalamic nucleus stimulation</term><term>visual memory</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Hélène Mollion MD</name><affiliations><json:string>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</json:string></affiliations></json:item><json:item><name>Peter Ford Dominey PhD</name><affiliations><json:string>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</json:string></affiliations></json:item><json:item><name>Emmanuel Broussolle MD</name><affiliations><json:string>Neurology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</json:string></affiliations></json:item><json:item><name>Jocelyne Ventre‐Dominey PhD</name><affiliations><json:string>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</json:string><json:string>INSERM Unit 846‐18, Avenue Doyen Lépine, 69675 Bron, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>motor execution</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>visual memory</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>functional dissociation</value></json:item></subject><articleId><json:string>MDS23769</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.52</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1529</abstractCharCount><pdfWordCount>5201</pdfWordCount><pdfCharCount>32704</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>210</abstractWordCount></qualityIndicators><title>Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title><refBibs><json:item><author><json:item><name>P Limousin</name></json:item><json:item><name>P Pollak</name></json:item><json:item><name>A 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neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23769</json:string></doi><id>346192D8FA7FD958C858317FE5152B218F0891D8</id><score>0.26631755</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/346192D8FA7FD958C858317FE5152B218F0891D8/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/346192D8FA7FD958C858317FE5152B218F0891D8/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/346192D8FA7FD958C858317FE5152B218F0891D8/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2011 Movement Disorder Society</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Funding agencies: This research was partially supported by a grant from CNRS (CTI grant) to J.V.D.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title><author xml:id="author-1"><persName><forename type="first">Hélène</forename><surname>Mollion</surname></persName><roleName type="degree">MD</roleName><affiliation>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Peter Ford</forename><surname>Dominey</surname></persName><roleName type="degree">PhD</roleName><affiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Emmanuel</forename><surname>Broussolle</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Jocelyne</forename><surname>Ventre‐Dominey</surname></persName><roleName type="degree">PhD</roleName><affiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</affiliation><affiliation>INSERM Unit 846‐18, Avenue Doyen Lépine, 69675 Bron, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2019">2019</biblScope><biblScope unit="page" to="2025">2025</biblScope></imprint></monogr><idno type="istex">346192D8FA7FD958C858317FE5152B218F0891D8</idno><idno type="DOI">10.1002/mds.23769</idno><idno type="ArticleID">MDS23769</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Parkinson's disease</term></item><item><term>subthalamic nucleus stimulation</term></item><item><term>motor execution</term></item><item><term>visual memory</term></item><item><term>functional dissociation</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-01-05">Received</change><change when="2011-04-03">Registration</change><change when="2011-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/346192D8FA7FD958C858317FE5152B218F0891D8/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="110"><doi origin="wiley" registered="yes">10.1002/mds.v26.11</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">11</numbering></numberingGroup><coverDate startDate="2011-09">September 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="110" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23769</doi><idGroup><id type="unit" value="MDS23769"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2011-01-05"></event><event type="manuscriptRevised" date="2011-03-30"></event><event type="manuscriptAccepted" date="2011-04-03"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.10 mode:FullText" date="2011-09-19"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-05-24"></event><event type="firstOnline" date="2011-05-24"></event><event type="publishedOnlineFinalForm" date="2011-09-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2019</numbering><numbering type="pageLast">2025</numbering></numberingGroup><correspondenceTo>INSERM Unit 846‐18, Avenue Doyen Lépine, 69675 Bron, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23769.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="61"></count><count type="wordTotal" number="6567"></count></countGroup><titleGroup><title type="main" xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease<link href="#fn1"></link><link href="#fn2"></link><link href="#fn3"></link></title><title type="short" xml:lang="en">Memory Function with Subthalamic Stimulation</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Hélène</givenNames><familyName>Mollion</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Peter Ford</givenNames><familyName>Dominey</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Emmanuel</givenNames><familyName>Broussolle</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Jocelyne</givenNames><familyName>Ventre‐Dominey</familyName><degrees>PhD</degrees></personName><contactDetails><email normalForm="jocelyne.ventre-dominey@inserm.fr">jocelyne.ventre‐dominey@inserm.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Neurology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">subthalamic nucleus stimulation</keyword><keyword xml:id="kwd3">motor execution</keyword><keyword xml:id="kwd4">visual memory</keyword><keyword xml:id="kwd5">functional dissociation</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Funding agencies:</b> This research was partially supported by a grant from CNRS (CTI grant) to J.V.D.</p></note><note xml:id="fn2"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="fn3"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Memory Function with Subthalamic Stimulation</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Hélène</namePart><namePart type="family">Mollion</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter Ford</namePart><namePart type="family">Dominey</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emmanuel</namePart><namePart type="family">Broussolle</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jocelyne</namePart><namePart type="family">Ventre‐Dominey</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron, France</affiliation><affiliation>INSERM Unit 846‐18, Avenue Doyen Lépine, 69675 Bron, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-09</dateIssued><dateCaptured encoding="w3cdtf">2011-01-05</dateCaptured><dateValid encoding="w3cdtf">2011-04-03</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">61</extent><extent unit="words">6567</extent></physicalDescription><abstract lang="en">Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: This research was partially supported by a grant from CNRS (CTI grant) to J.V.D.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>keywords</genre><topic>Parkinson's disease</topic><topic>subthalamic nucleus stimulation</topic><topic>motor execution</topic><topic>visual memory</topic><topic>functional dissociation</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>2019</start><end>2025</end><total>7</total></extent></part></relatedItem><identifier type="istex">346192D8FA7FD958C858317FE5152B218F0891D8</identifier><identifier type="DOI">10.1002/mds.23769</identifier><identifier type="ArticleID">MDS23769</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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