ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:9055801

The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients

Identifieur interne : 004411 ( Main/Exploration ); précédent : 004410; suivant : 004412

The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients

Auteurs : O. Rascol [France] ; U. Sabatini [Italie] ; N. Fabre [France] ; C. Brefel [France] ; I. Loubinoux [France] ; P. Celsis [France] ; J. M. Senard [France] ; J. L. Montastruc [France] ; F. Chollet [France]

Source :

Brain [ 0006-8950 ] ; 1997.

RBID : Pascal:97-0171682

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Akinésie, Mouvement, Main, Tomoscintigraphie, Photon, Débit sanguin régional, Cervelet, Exploration, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Akinesia, Brain Mapping, Cerebellum, Cerebellum (diagnostic imaging), Cerebellum (physiopathology), Cerebrovascular Circulation, Emission tomography, Exploration, Hand, Human, Humans, Levodopa (therapeutic use), Middle Aged, Motion, Motor Cortex (physiopathology), Movement, Parkinson Disease (diagnostic imaging), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Photon, Regional blood flow, Tomography, Emission-Computed, Single-Photon.
MESH :
- chemical , therapeutic use : Levodopa.
- diagnostic imaging : Cerebellum, Parkinson Disease.
- drug therapy : Parkinson Disease.
- physiopathology : Cerebellum, Motor Cortex, Parkinson Disease.
- Brain Mapping, Cerebrovascular Circulation, Hand, Humans, Middle Aged, Movement, Tomography, Emission-Computed, Single-Photon.

Abstract

We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. ¹³³Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.

Affiliations:

Le document en format XML

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<term>Brain Mapping</term>
<term>Cerebellum</term>
<term>Cerebellum (diagnostic imaging)</term>
<term>Cerebellum (physiopathology)</term>
<term>Cerebrovascular Circulation</term>
<term>Emission tomography</term>
<term>Exploration</term>
<term>Hand</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Middle Aged</term>
<term>Motion</term>
<term>Motor Cortex (physiopathology)</term>
<term>Movement</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Photon</term>
<term>Regional blood flow</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Cerebellum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellum</term>
<term>Motor Cortex</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Brain Mapping</term>
<term>Cerebrovascular Circulation</term>
<term>Hand</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Movement</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Akinésie</term>
<term>Mouvement</term>
<term>Main</term>
<term>Tomoscintigraphie</term>
<term>Photon</term>
<term>Débit sanguin régional</term>
<term>Cervelet</term>
<term>Exploration</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. <sup>133</sup>
Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Italie</li>
</country>
<region><li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Toulouse</li>
</settlement>
</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name>
</region>
<name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C." last="Brefel">C. Brefel</name>
<name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C." last="Brefel">C. Brefel</name>
<name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P." last="Celsis">P. Celsis</name>
<name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F." last="Chollet">F. Chollet</name>
<name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N." last="Fabre">N. Fabre</name>
<name sortKey="Loubinoux, I" sort="Loubinoux, I" uniqKey="Loubinoux I" first="I." last="Loubinoux">I. Loubinoux</name>
<name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J. L." last="Montastruc">J. L. Montastruc</name>
<name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name>
<name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name>
<name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J. M." last="Senard">J. M. Senard</name>
</country>
<country name="Italie"><noRegion><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U." last="Sabatini">U. Sabatini</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson en France (serveur d'exploration)

The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients

The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients

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	La maladie de Parkinson en France (serveur d'exploration)
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