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La maladie de Parkinson en France (serveur d'exploration)

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The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients

Identifieur interne : 001886 ( PascalFrancis/Curation ); précédent : 001885; suivant : 001887

The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients

Auteurs : O. Rascol [France] ; U. Sabatini [Italie] ; N. Fabre [France] ; C. Brefel [France] ; I. Loubinoux [France] ; P. Celsis [France] ; J. M. Senard [France] ; J. L. Montastruc [France] ; F. Chollet [France]

Source :

RBID : Pascal:97-0171682

Descripteurs français

English descriptors

Abstract

We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. 133Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.
pA  
A01 01  1    @0 0006-8950
A03   1    @0 Brain
A05       @2 120
A06       @3 p.1
A08 01  1  ENG  @1 The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients
A11 01  1    @1 RASCOL (O.)
A11 02  1    @1 SABATINI (U.)
A11 03  1    @1 FABRE (N.)
A11 04  1    @1 BREFEL (C.)
A11 05  1    @1 LOUBINOUX (I.)
A11 06  1    @1 CELSIS (P.)
A11 07  1    @1 SENARD (J. M.)
A11 08  1    @1 MONTASTRUC (J. L.)
A11 09  1    @1 CHOLLET (F.)
A14 01      @1 Department of Medical and Clinical Pharmacology, University Hospital @2 Toulouse @3 FRA @Z 1 aut. @Z 4 aut. @Z 7 aut. @Z 8 aut.
A14 02      @1 INSERM U455, University Hospital @2 Toulouse @3 FRA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 9 aut.
A14 03      @1 Istituto Mediterraneo di Neuroscienze Sanatrix @2 Pozzili @3 ITA @Z 2 aut.
A14 04      @1 Departments of Neurology, University Hospital @2 Toulouse @3 FRA
A20       @1 103-110
A21       @1 1997
A23 01      @0 ENG
A43 01      @1 INIST @2 998 @5 354000063119560090
A44       @0 0000 @1 © 1997 INIST-CNRS. All rights reserved.
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A47 01  1    @0 97-0171682
A60       @1 P
A61       @0 A
A64 01  1    @0 Brain
A66 01      @0 GBR
C01 01    ENG  @0 We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. 133Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.
C02 01  X    @0 002B17G
C03 01  X  FRE  @0 Parkinson maladie @5 01
C03 01  X  ENG  @0 Parkinson disease @5 01
C03 01  X  SPA  @0 Parkinson enfermedad @5 01
C03 02  X  FRE  @0 Akinésie @5 04
C03 02  X  ENG  @0 Akinesia @5 04
C03 02  X  SPA  @0 Aquinesia @5 04
C03 03  X  FRE  @0 Mouvement @5 07
C03 03  X  ENG  @0 Motion @5 07
C03 03  X  GER  @0 Bewegung @5 07
C03 03  X  SPA  @0 Movimiento @5 07
C03 04  X  FRE  @0 Main @5 08
C03 04  X  ENG  @0 Hand @5 08
C03 04  X  SPA  @0 Mano @5 08
C03 05  X  FRE  @0 Tomoscintigraphie @5 10
C03 05  X  ENG  @0 Emission tomography @5 10
C03 05  X  SPA  @0 Tomocentelleografía @5 10
C03 06  X  FRE  @0 Photon @5 11
C03 06  X  ENG  @0 Photon @5 11
C03 06  X  GER  @0 Photon @5 11
C03 06  X  SPA  @0 Fotón @5 11
C03 07  X  FRE  @0 Débit sanguin régional @5 13
C03 07  X  ENG  @0 Regional blood flow @5 13
C03 07  X  SPA  @0 Flujo sanguíneo regional @5 13
C03 08  X  FRE  @0 Cervelet @5 16
C03 08  X  ENG  @0 Cerebellum @5 16
C03 08  X  SPA  @0 Cerebelo @5 16
C03 09  X  FRE  @0 Exploration @5 17
C03 09  X  ENG  @0 Exploration @5 17
C03 09  X  SPA  @0 Exploración @5 17
C03 10  X  FRE  @0 Homme @5 20
C03 10  X  ENG  @0 Human @5 20
C03 10  X  SPA  @0 Hombre @5 20
C07 01  X  FRE  @0 Système nerveux pathologie @5 37
C07 01  X  ENG  @0 Nervous system diseases @5 37
C07 01  X  SPA  @0 Sistema nervioso patología @5 37
C07 02  X  FRE  @0 Système nerveux central pathologie @5 38
C07 02  X  ENG  @0 Central nervous system disease @5 38
C07 02  X  SPA  @0 Sistema nervosio central patología @5 38
C07 03  X  FRE  @0 Encéphale pathologie @5 39
C07 03  X  ENG  @0 Cerebral disorder @5 39
C07 03  X  SPA  @0 Encéfalo patología @5 39
C07 04  X  FRE  @0 Extrapyramidal syndrome @5 40
C07 04  X  ENG  @0 Extrapyramidal syndrome @5 40
C07 04  X  SPA  @0 Extrapiramidal síndrome @5 40
C07 05  X  FRE  @0 Maladie dégénérative @5 41
C07 05  X  ENG  @0 Degenerative disease @5 41
C07 05  X  SPA  @0 Enfermedad degenerativa @5 41
C07 06  X  FRE  @0 Trouble neurologique @5 48
C07 06  X  ENG  @0 Neurological disorder @5 48
C07 06  X  SPA  @0 Trastorno neurológico @5 48
C07 07  X  FRE  @0 Trouble moteur @5 49
C07 07  X  ENG  @0 Motor system disorder @5 49
C07 07  X  SPA  @0 Trastorno motor @5 49
C07 08  X  FRE  @0 Exploration radioisotopique @5 61
C07 08  X  ENG  @0 Radionuclide study @5 61
C07 08  X  SPA  @0 Exploración radioisotópica @5 61
C07 09  X  FRE  @0 Hémodynamique @5 69
C07 09  X  ENG  @0 Hemodynamics @5 69
C07 09  X  SPA  @0 Hemodinámica @5 69
N21       @1 083

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Pascal:97-0171682

Le document en format XML

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<term>Exploration</term>
<term>Hand</term>
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<term>Motion</term>
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<div type="abstract" xml:lang="en">We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v.
<sup>133</sup>
Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.</div>
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<s0>We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v.
<sup>133</sup>
Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.</s0>
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