The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients.
Identifieur interne : 001E52 ( Ncbi/Curation ); précédent : 001E51; suivant : 001E53The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients.
Auteurs : O. Rascol [France] ; U. Sabatini ; N. Fabre ; C. Brefel ; I. Loubinoux ; P. Celsis ; J M Senard ; J L Montastruc ; F. CholletSource :
- Brain : a journal of neurology [ 0006-8950 ] ; 1997.
English descriptors
- KwdEn :
- Brain Mapping, Cerebellum (diagnostic imaging), Cerebellum (physiopathology), Cerebrovascular Circulation, Hand, Humans, Levodopa (therapeutic use), Middle Aged, Motor Cortex (physiopathology), Movement, Parkinson Disease (diagnostic imaging), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , therapeutic use : Levodopa.
- diagnostic imaging : Cerebellum, Parkinson Disease.
- drug therapy : Parkinson Disease.
- physiopathology : Cerebellum, Motor Cortex, Parkinson Disease.
- Brain Mapping, Cerebrovascular Circulation, Hand, Humans, Middle Aged, Movement, Tomography, Emission-Computed, Single-Photon.
Abstract
We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. 133Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.
PubMed: 9055801
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001546
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001505
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001505
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001E52
Links to Exploration step
pubmed:9055801Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients.</title><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical and Clinical Pharmacology, University Hospital, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical and Clinical Pharmacology, University Hospital, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N" last="Fabre">N. Fabre</name></author><author><name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C" last="Brefel">C. Brefel</name></author><author><name sortKey="Loubinoux, I" sort="Loubinoux, I" uniqKey="Loubinoux I" first="I" last="Loubinoux">I. Loubinoux</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9055801</idno><idno type="pmid">9055801</idno><idno type="wicri:Area/PubMed/Corpus">001546</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001546</idno><idno type="wicri:Area/PubMed/Curation">001505</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001505</idno><idno type="wicri:Area/PubMed/Checkpoint">001505</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001505</idno><idno type="wicri:Area/Ncbi/Merge">001E52</idno><idno type="wicri:Area/Ncbi/Curation">001E52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients.</title><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical and Clinical Pharmacology, University Hospital, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical and Clinical Pharmacology, University Hospital, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N" last="Fabre">N. Fabre</name></author><author><name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C" last="Brefel">C. Brefel</name></author><author><name sortKey="Loubinoux, I" sort="Loubinoux, I" uniqKey="Loubinoux I" first="I" last="Loubinoux">I. Loubinoux</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="ISSN">0006-8950</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Mapping</term><term>Cerebellum (diagnostic imaging)</term><term>Cerebellum (physiopathology)</term><term>Cerebrovascular Circulation</term><term>Hand</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Movement</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Cerebellum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellum</term><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Brain Mapping</term><term>Cerebrovascular Circulation</term><term>Hand</term><term>Humans</term><term>Middle Aged</term><term>Movement</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. 133Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E52 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001E52 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:9055801
|texte= The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:9055801" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |